Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 53-61
RADIATION THERAPY
L.I. Musabaeva1, V.A. Lisin1,2, Zh.A. Startseva1, O.V. Gribova1, V.V. Velikaya1, A.A. Melnikov1
Neutron Therapy on U-120 Cyclotron
1. Cancer Research Institute, Siberian Branch of the RAMS, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. National Research Tomsk Polytechnic University
ABSTRACT
The review is devoted to the 30-year neutron therapy experience in cancer treatment at the Tomsk Cancer Research Institute. In 1983, the Institute of Nuclear Physics affiliated to the Tomsk Polytechnic University was the first in Russia to perform radiation therapy with fast neutrons for cancer patients. Neutron therapy at the initial stage included the formation of the therapeutic fast neutron beam with the average energy of 6.3 MeV, dosimetric and radiobiological studies, clinical trials and accumulation of the own experience in the treatment of resistant tumors with fast neutrons. Efficacy of new methods of neutron and concurrent neutron-photon therapy, optimal regimens of combined modality treatment and independent radiation therapy were studied. The comprehensive programme on the prevention and treatment of acute radiation-induced complications and radiation damages to normal tissues and critical organs was developed.
Content
Introduction
Purpose of the study
Dosimetric and radiobiological studies
Clinical trials
Patterns of tumor reoxygenation in fast neutron therapy
Parotid salivary gland
Thyroid cancer
Neutron therapy for patients with locally advanced T2–4N0–2M0 breast cancer
Pathological tumor response to preoperative neutron therapy
Fast neutrons in the treatment of locally recurrent breast cancer
Cytogenetic studies in cancer patients who received neutron therapy
Conclusion
Key words: therapeutic channel, resistant tumor forms, neutron Therapy