Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 6. P. 5-8


V.F. Stepanenko, I.G. Belukha, D.V. Dubov, E.K. Yaskova, A.F. Tsyb

Nanodosymetric Basing of Selective Irradiation to Chromosomes with Cascade Irradiatora of Low-Energy Electrons

Medical Radiological Research Center, Obninsk, Kaluga region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Nanodosimertry data as a ground for the possibility of selective irradiation on chromosomes by cascade emitters of low energy Auger electrons and photoelectrons, generated by the photoelectric effect on the native and on the incorporated atoms in the DNA resulted from external irradiation by low-energy photons, are presented. A theoretical evaluation of the biological effectiveness of photon activation effect on cultured B-16 melanoma cells with included to the DNA molecule of stable bromine or iodine atoms was performed.

Key words: nanodosimetry, chromosomes, cascade irradiators of electrons


  1. Adelstein S.J., Kassis A.I., Burt R.W., eds. Dosimetry of administered radionuclides. Washington, DC.: American College of Nuclear Physicians. 1990. 256 p.
  2. Datta K., Weinfeld M., Neumann R.D. et al. Determination and analysis of site-specific 125I decay-induced DNA double-strand break end-group structures. Radiat. Res. 2007. Vol. 167. P. 152-166.
  3. Kasssis A.I., Makrigiorgus G.M., Adelstein S.J. Implications of radiobiological and dosimetric studies of DNA-incorporated 123I: the use of the Auger effect as a biological probe at the nanometer level. Radiat. Protection Dosimetry. 1990. Vol. 31. P. 333-338.
  4. Sastry R.S.R. Biological effects of the Auger emitter 125I: a review. Report No. 1 of AAPM Nuclear Medicine Task Group No. 6. Med. Phys. 1992. Vol. 19. P. 1361-1370.
  5. Briemeister J.F. MCNP - A General Monte-Carlo n-particle Transport Code with Data Library ENDFB/ 6. Los Alamos. 1997. Version 4B.
  6. Howell R.W. Radiation spectra for Auger-electron emitting nuclides. Report No. 2 of AAPM Nuclear Medicine Task Group No. 6. Med. Phys. 1992. Vol. 19. P. 1371-1383.
  7. Goddu S.M., Dandamudi V.R., Howell R.W. Multicellular dosimetry for micrometastases: dependence of self-dose versus cross-dose to cell nuclei on type and energy of radiation and subcellular distribution of radionuclides. J. Nucl. Med. 1993. Vol. 35. No. 3. P. 521-529.
  8. Mileo A.M., Mattei E., Fanuele M. et al. Differential radiosensitivity in cultured B-16 melanoma cells. Pigment Cell Res. 1989. Vol. 2. P. 167-170.