Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. P. 82–87

Yu.D. Udalov¹, A.S. Samoylov², L.A. Danilova¹, E.L. Slobina¹, E.M. Stepanyuchenko¹,
I.A. Bogomolova¹, N.V. Kashentseva¹, V.A. Kiselev¹, A.A. Vanchugov¹,
V.A. Andreev¹, E.A. Stepanov¹

Modern Treatment of Non-Small Cell Lung Cancer with Intracerebral Metastases
and Extracranial Metastatic Affection of Liver, Mediastinal Lymph Nodes, Skeletal Bones.
Clinical Observation

¹Federal High-Technology Centre for Medical Radiology, Dimitrovgrad, Russia

²A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Ludmila Alekseevna Danilova: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Introduction: The article covers issues related to modern methods of treatment of non-small cell lung cancer (NSCLC) with multiple synchronous metastases in brain, liver, mediastinal lymph nodes, skeletal bones and describes a clinical case of modern effective treatment and long-term follow-up of a patient with advanced NSCLC and extra- and intracranial metastatic spread.

Purpose: Evaluation of modern methods of special antitumor treatment and their application in clinical practice for the treatment of metastatic NSCLC.

Material and methods: Modern methods of proton and photon radiation therapy, targeted therapy are considered.

Results: The use of modern methods of special antitumor therapy has increased the overall and relapse-free survival rate of patients with multiple metastases of NSCLC in brain, liver, mediastinal lymph nodes, skeletal bones reducing the need for additional interventions. This is confirmed by a long-term follow-up after modern effective antitumor treatment of a patient with advanced NSCLC and synchronous progression in the form of extra- and intracranial metastatic spread. The patient has been alive for more than 2 years from the moment of progression with an estimated life expectancy of 4–5 months.

Conclusion: Modern methods of special antitumor therapy can increase the survival rate of patients with multiple synchronous NSCLC metastases in brain, liver, mediastinal lymph nodes, skeletal bones without significant deterioration in their quality of life.

Key words:non-small cell lung cancer, intracerebral (intracranial) metastases, extracranial metastases, targeted therapy, proton and photon radiation therapy

For citation: Udalov YuD, Samoylov AS, Danilova LA, Slobina EL, Stepanyuchenko EM, Bogomolova IA, Kashentseva NV, Kiselev VA, Vanchugov AA, Andreev VA, Stepanov EA. Modern Treatment of Non-Small Cell Lung Cancer with Intracerebral Metastases and Extracranial Metastatic Affection of Liver, Mediastinal Lymph Nodes, Skeletal Bones. Clinical Observation.  Medical Radiology and Radiation Safety. 2021;66(3):82-87.

DOI: 10.12737/1024-6177-2021-66-3-82-87

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 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 23.12.2020. 

Accepted for publication: 20.01.2021.