Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 62–69

Subacute Course of Chronic Radiation Syndrome Caused External 
Non-Uniform Radiation Exposure of Lost Source

I.A. Galstyan, A.Yu. Bushmanov, N.A. Metlyaeva, V.Yu. Soloviev, L.Yu. Mershin, M.V. Konchalovsky,
V.Yu. Nugis, O.V. Shcherbatykh, L.A. Yunanova, F.S. Torubarov, A.A. Davtian, E.E. Obuhova

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Irina Alekseevna Galstyan: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: To analyze the features of the clinical course of chronic radiation syndrome (CRS) due to external non-uniform chronic exposure to prolonged household contact with a lost source of ionizing radiation.

Material and methods: Analysis of 2 clinical observations of patients who developed subacutecourse of CRS and chronic radiation dermatitis due to external non-uniform exposure of the lost sources of ionizing radiation are presented.

Results: Boy A. K. from the age of 1 year for 7 years was external radiation exposed (for 1.5 years non-uniform exposure ) to the total dose according EPR tooth enamel about 6.3 Gy, according to the data of retrospective dose recovery on red bone marrow using voxel modeling – 26 (19–37) Gy.

F. V. V., male, 38 years, was external non-uniform radiation exposed for 5 months, the total dose according cytogenetic studies of 7.9 Gy (dose rate about 0.035 Gy/h).

During the examination in the hospital, the patients were diagnosed with CRS. Within the framework of the bone marrow syndrome, deep thrombocytopenia, moderate leuko- and neutropenia, and moderate anemic syndrome were observed. The latter is not typical for the typical course of CRS and is a criterion indicating a subacute course of the disease. In addition, signs of chronic radiation dermatitis were found in the projection of the action of the ionizing radiation beam. After stopping the radiation exposure, the patients did not recover their hematopoietic function, and in the period of immediate consequences, they developed myelodysplastic syndrome (MDS) with further transformation into acute leukemia.

Conclusion: 1. Accidental prolonged household or criminal contact with a source of ionizing radiation can lead to the formation of CRS with an atypical subacute course and the formation of MDS with transformation to acute leukemia in the outcome of the disease or in the period of its consequences.

2. It can be assumed that with external non-uniform radiation exposure, leading to the development of CRS and chronic radiation damage to the skin, agranulocytosis in the subacute course of CRS may be absent.

3. Adverse prognostic signs for the development of MDS and leukemia in the outcome or in the period of the consequences of subacute CRS with non-uniform exposure are long-lasting deep thrombocytopenia and anemic syndrome after the end of radiation exposure.

Keywords: chronic radiation syndrome, subacute course, non-uniform radiation exposure, lost radiation source, agranulocytosis, anemic syndrome, myelodysplastic syndrome, acute leukemia

For citation: Galstyan IA, Bushmanov AYu, Metlyaeva NA, Soloviev VYu, Mershin LYu, Konchalovsky MV, Nugis VYu, Shcherbatykh OV, Yunanova LA, Torubarov FS, Davtian AA, Obuhova EE. Subacute Course of Chronic Radiation Syndrome Caused External Non-Uniform Radiation Exposure of Lost Source. Medical Radiology and Radiation Safety. 2021;66(4):62-69.

DOI: 10.12737/1024-6177-2021-66-4-62-69



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 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.


Article received: 16.02.2021. 

Accepted for publication: 20.04.2021.