Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 89–100
To the Question About Pharmacological Protection During Irradiation
in Non-infecting Doses: Maybe, Necessary?
Part 1.
General Overview of Medical-tactical and Phenomenological Aspects
A.V. Ivanchenko1, V.A. Basharin2, I.S. Drachev1, A.B. Seleznev1, A.Yu. Bushmanov3
1Scientific Research Testing Institute of Military Medicine, St. Petersburg, Russia.
2S.M. Kirov Military Medical Academy, St. Petersburg, Russia.
3A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Alexander Viktorovich Ivanchenko, This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Review of modern concepts of the biological effect of ionizing radiation in medium doses on a living organism and the consequences of radiation in order to assess the need for the use of drugs suitable for the purpose of modifying the effects; stimulation of discussion on the issue under consideration.
Results: The conditions of origin and the list of possible radiation effects from irradiation at medium doses of the 0.1–1 Gy range were assessed, the scale and phenomenology of the consequences were assessed as a subject of modification by antiradiation agents.
Conclusions: Pharmacological support (use of PLC) under conditions of short-term and prolonged irradiation with a low dose rate and in the dose range of 0.2–1 Gy seems to be necessary due to the reality of deterministic effects when the dose limits are exceeded (partly at the premorbid or preclinical level, with pronounced psychogenic reactions – components of the final state), as well as with the possibility of stochastic effects in excess of spontaneous ones, although, according to approximate estimates, with an insignificant frequency.
Key words: irradiation, average doses, antiradiation agents, disputable use
For citation: Ivanchenko A.V., Basharin V.A., Drachev I.S., Seleznev A.B., Bushmanov A.Yu. To the Question About Pharmacological Protection During Irradiation in Non-infecting Doses: Maybe, Necessary? Part 1.Ggeneral Overview of Medical-Tactical and Phenomenological Aspects. Medical Radiology and Radiation Safety. 2021;66(4):89-100.
DOI: 10.12737/1024-6177-2021-66-4-89-100
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Conflict of interest. The authors declare no conflict of interest.
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Contribution. Article was prepared with equal participation of the authors.
Article received: 16.02.2021.
Accepted for publication: 20.04.2021.