Medical Radiology and Radiation Safety. 2021. Vol. 66. № 5. P. 33–38

Sodium Deoxyribonucleate Prevents Radiation Cystitis in Uterine or Cervical Cancer Patients

P.I. Skopin1, A.A. Ivashin1, Yu.A. Skopina1, Yu.V Kozina 2, R. A. Zukov 2,3 , A.V. Siprov1, E.V. Slepov2

1N.P. Ogarev National Research Mordovia State University, Saransk, Russia.

2A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncological Dispensary, Krasnoyarsk, Russia

3V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

Contact person: Artem Aleksandrovich Ivashin: This email address is being protected from spambots. You need JavaScript enabled to view it.


Results: To develop a method for reducing the frequency and severity of early radiation reactions in patients with cancer of the uterus or cervix.

Material and methods: We analyzed the results of treatment of 60 patients with cancer of the uterus and cervix, patients received a postoperative course of external beam radiotherapy combined with the intramuscular administration of the Derinat® radioprotector (sodium deoxyribonucleate); in the second arm, they received a postoperative course of external beam radiotherapy and standard therapy in case of radiation cystitis. The assessment of radiation reactions severity was performed with the EORTC QLQ-C30 criteria, WBC count, IPSS scale, urine analysis and cystoscopic examination evaluated with the developed by us scale.

Results: Evaluation of the quality of life in patients with cervical or uterine cancer at the final stage of treatment using the IPSS scale showed that in the arm of patients with sodium deoxyribonucleate, there was a 30.4 % (p> 0.05) decrease in the symptoms of urinary disorders. The use of the radioprotector sodium deoxyribonucleate also statistically significantly reduced the incidence of radiation cystitis by 73 %. According to cystoscopy, the total bladder injury score at the end of treatment was 147 % lower. The number of leukocytes in the urine analysis at the end of treatment was 116.3 % lower (p≤0.01) in those who received sodium deoxyribonucleate

Conclusion: The data obtained indicate the radioprotective efficacy of sodium deoxyribonucleate and make it possible to recommend its intramuscular administration to patients with cancer of the uterus and cervix against the background of external beam radiation therapy to reduce the frequency and severity of acute radiation cystitis in patients with cancer of the uterus or cervical cancer receiving external beam radiation therapy.

Key words: radiation cystitis, uterine cancer, cervical cancer, sodium deoxyribonucleate

For citation: Skopin PI, Ivashin AA,  Skopina Yu.A,  Kozina YuV,  Zukov R A.  Siprov AV, Slepov EV. Sodium Deoxyribonucleate Prevents Radiation Cystitis in Uterine or Cervical Cancer Patients. Medical Radiology and Radiation Safety. 2021;66(5):30-35.

DOI: 10.12737/1024-6177-2021-66-5-33-38


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Conflict of interest. The author declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors

Article received: 17.02.2021. 

Accepted for publication: 20.04.2021.