Medical Radiology and Radiation Safety. 2022. Vol. 67. № 1

Reirradiation of High-Grade Brain Gliomas:
Availability and Risks. Literature Review

K.E.Medvedeva, I.A.Gulidov, D.V.Gogolin

A.F. Tsyb Medical Radiological Research Centre, Obninsk, Russia

Contact person: Medvedeva Kira Evgenievna: This email address is being protected from spambots. You need JavaScript enabled to view it.


High-grade gliomas are the most common type of primary brain tumor in adults. A distinctive feature of malignant gliomas is their high aggressiveness, resistance to various types of treatment, and high recurrence rate. Depending on the grade of malignancy, a relapse can occur in months or years, however, it is inevitable for almost all patients with this type of tumor. Despite the improvement of treatment methods, the problem of recurrence of malignant brain gliomas remains relevant: reoperation is associated with the risk of developing severe neurological deficits, and previous chemotherapy often leads to severe hematological toxicity. Thus, re-irradiation is seen as an effective treatment option for tumor recurrence.

This review of the scientific literature examines various aspects of re-irradiation of high-grade gliomas, provides data on the features of diagnosis and treatment results in patients, as well as the frequency of complications.

Keywords: high-grade brain gliomas, recurrence, proton therapy, reirradiation

For citation: Medvedeva KE, Gulidov IA, Gogolin DV. Reirradiation of High-Grade Brain Gliomas: Availability and Risks. Literature Review. Medical Radiology and Radiation Safety. 2022;67(1):77-82.

DOI: 10.12737/1024-6177-2022-67-1-77-82


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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 17.07.2021. 

Accepted for publication: 05.09.2021