Medical Radiology and Radiation Safety. 2022. Vol. 67. № 1

Investigation of the Microelement Content of Intervertebral Disc
in Osteochondrosis of the Lumbar Spine

S.S. Kochkartaev1, E.A. Danilova2, Sh.Sh. Shatursunov1,
N.S. Osinskaya2

1Republican Scientific and Practical Medical Center of Traumatology and Orthopedics, Tashkent, Uzbekistan

2Institute of Nuclear Physics, Tashkent, Uzbekistan

Contact person: Danilova Elena Artovazdovna: This email address is being protected from spambots. You need JavaScript enabled to view it.


The progressive prevalence, significant economic losses, the cost of compulsory health insurance and high-tech medical care have turned the problem of lumbar osteochondrosis into a socially significant issue. The relevance of this problem is dictated by the need to study the etiopathogenesis of the course of degenerative changes for an integrated approach when choosing an adequate treatment.

The progression of the pathological process in the spine significantly contributes to changes in the metabolism of connective tissue, which is closely associated with the violation of microelements.

Purpose: Evaluation of changes in the homeostasis of the intervertebral disc, in particular the study of the microelement composition of the intervertebral disc at various stages of development of hernias of the lumbar spine using instrumental neutron activation analysis.

Material and methods: The studied biomaterial was obtained intraoperatively, with traditional microdiscectomy in herniations of the spine at the level of VL3-4, VL4-5, VL5-S1. By the method of instrumental neutron activation analysis, a study of biomaterials, represented by tissue fragments of the remote part of the hernia of the intervertebral disc, located at different stages of the degenerative process, was carried out.

Results: The quantitative content of 22 macro- and microelements in the removed fragments was determined. As a result of the data obtained, it was found that in the tissues of the intervertebral discs, a gradual change in the content of a number of essential elements occurs, depending on the stage of development of the degeneration process.

Conclusion: Changes in the microelement composition indicate metabolic processes occurring in the intervertebral discs, and the relationship of the microelement composition of the disc tissue and the course of the degenerative process can be used to predict the condition of the patient and choose an adequate treatment.

Keywords: osteochondrosis, disc herniation, intervertebral discs, neutron activation analysis, microelements

For citation: Kochkartaev SS, Danilova EA, Shatursunov ShSh, Osinskaya NS. Investigation of the Microelement Content of Intervertebral Disc in Osteochondrosis of the Lumbar Spine. Medical Radiology and Radiation Safety. 2022;67(1):83-86.

DOI: 10.12737/1024-6177-2022-67-1-83-86


1. Drivotinov B.V., Ban D.S. The Role of the Reactive-Inflammatory and Scar-Adhesive Process in the Pathogenesis, Clinic and Treatment of Neurological Manifestations of lumbar osteochondrosis. Meditsinskiy zhurnal. Minsk. 2006;2:21˗23 (In Russ.).

2. Zhuravlev Yu.I., Nazarenko G.I., Cherkashov A.M., et all. Prediction of the Outcome of Surgical Treatment of Degenerative Disease of the Intervertebral Discs of the Lumbosacral Spine. Voprosy neyrokhirurgii im. N.N. Burdenko. 2009;1:42˗47 (In Russ.).

3. Korzh N.A., Prodan A.I., Barysh A.E. Degenerative Diseases of the Spine and Their Structural and Functional Classification. Ukrainian Neurosurgical Journal. 2004;3:27-30 (In Ukr.).

4. Jiil P.G., Urban and Sally Roberts. Degeneration of the Intervertebral Disc. Arthritis Research Therapy. 2003;5;3:120-130.

5. Vasilyeva I.G., KHizhnyak M.V., et al. Degeneration of Intervertebral Discs and Methods for its Biological Correction. Ukrainian Neurosurgical Journal. 2010;1:16˗23 (In Ukr.).

6. Zaydman A.M., Filippova G.N. Strukturno-Metabolicheskiye Osobennosti Mezhpozvonkovogo Diska pri Osteokhondroze i Vozmozhnosti Yego Korrektsii = Structural and Metabolic Features of the Intervertebral Disc in Osteochondrosis and the Possibility of its Correction. Patologiya Pozvonochnika. Leningrad Publ., 1980. P. 88-94 (In Russ.).

7. Tsivyan YA.L., Raykhinshteyn V.YE. Mezhpozvonkovyye Diski: Nekotoryye Aspekty Fiziologii i Biomekhaniki = Intervertebral Discs: Some Aspects of Physiology and Biomechanics. Novosibirsk, Nauka. Sib. Otdeleniye Publ., 1977. 165 p. (In Russ.).

8. Avtsyn A.P., ZHavoronkov A.A. Mikroelementozy Cheloveka = Microelements of a Person. Moscow, Meditsina Publ., 1991. 496 p. (In Russ.).

9. Vernadskiy V.I. Khimicheskiy Sostav Zhivogo Veshchestva = The Chemical Composition of Living Matter. Moscow Publ., 1922. (In Russ.).

10. Byvaltsev V., Belykh E., Panasenkov S., et al. Nanostructural Changes of Intervertebral Disc after Diode Laser Ablation. World Neurosurgery. 2012;77;1:6–7.

11. Skalnyy A.V., Rudakov I.A. Bioelementy v Meditsine = Bioelements in Medicine. Moscow, Oniks 21 vek, Mir Publ., 2004. 272 p. (In Russ.).

12. Babenko G.A., Reshetkina A.P. Primeneniye Mikroelementov v Meditsine = The Use of Trace Elements in Medicine. Kiev Publ., 1971. 311 р. (In Russ.).

13. Mednis I.V. Gamma-Izlucheniye Radionuklidov, Primenyayemykh v Neytronno-Aktivatsionnom Analize = Gamma Radiation of Radionuclides Used in Neutron Activation Analysis. Directory. Riga, Zinatne Publ., 1987. 212 р. (In Russ.).

14. Podkolzin A.A., Dontsov V.I. Immunitet i Mikroelementy = Immunity and Microelements. Moscow Publ., 1994. 144 р. (In Russ.). 

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 17.07.2021. 

Accepted for publication: 05.09.2021