Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4

Research of Dosimetric Characteristics of Human Hair Depending on the Content of Melanine

D.V. Ivanov^1,3, D.R. Baitimirov¹, S.F. Konev¹, E.K. Vasilenko²,
E.E. Aladova²

¹B.N. Yeltsin Urals Federal University, Yekaterinburg, Russia

²Southern Urals Biophysics Institute, Ozersk, Russia

³M.N. Mikheev Institute of Metal Physics, Ural Branch of the RAS, Yekaterinburg, Russia

Contact person: Aladova Е.Е., e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Investigation of paramagnetic properties of radiation-induced centers that occur when hair samples are irradiated with ionizing radiation, depending on the color of the sample.

Material and methods: A Bruker Elexsys E580 electron paramagnetic resonance spectrometer was used. To improve the signal-to-noise ratio, the spectrum was recorded with three accumulations with a constant scan time equal to one minute. Measurements were made using a highly sensitive rectangular Bruker SuperHighQ resonator. For irradiation of samples, the linear electron accelerator UELR-10-10С2 of the innovation and implementation center for radiation sterilization of the Urals Federal University (Institute of Physics and technology) was used.

Results: Research of the EPR signal parameters of the melanin in hair samples of different colors (black, brown, red and gray with different degrees of pigmentation) showed that the intensity of the EPR signal varies depending on the hair color. The higher the radiation sensitivity of the hair, the lighter the color of the hair. The melanin signal, which is the background for the radiation-induced signal, increases with increasing intensity of hair color.

Key words: dosimetry, electron paramagnetic resonance, melanin, radiation sensitivity, human hairs

For citation: Ivanov DV, Baitimirov DR, Konev SF, Vasilenko EK, Aladova EE. Research of Dosimetric Characteristics of Human Hair Depending on the Content of Melanine. Medical Radiology and Radiation Safety. 2022;67(4):89-95. DOI: 10.33266/1024-6177-2022-67-4-89-95

References

1. Ivanov D.V., Baytimirov D.R., Konev S.F., Aladova Ye.Ye., Vasilenko Ye.K. Possibility of Various Materials to Be Used for EPR Dosimetry in Cases of Emergency Radiation Exposure. Voprosy Radiatsionnoy Bezopasnosti = Journal of Radiation Safety Issues. 2018;3:75-81 (In Russ).

2. Gordy W., Ard W.B., Shieids H. Proc. Nat. Acad. Sci. 1955;41:983-996. DOI: 10.1073/pnas.41.11.983.

3. Chernova O.F., Tselikova T.N. Atlas of Hair of Mammals. Tonkaya Struktura Ostevykh Volos i Igl v Skaniruyushchem Elektronnom Mikroskope = The Fine Structure of Guard Hairs and Needle in a Scanning Electron Microscope. Moscow, Tovarishchestvo Nauchnykh Izdaniy KMK Publ., 2004 (In Russ).

4. Goldstein B., Gibson J., Henderson R., et al. Biological Markers in Environmental Health Research. Environ. Health Persp. 1987;74:3-9. DOI: 10.1289/ehp.87743. 

5. Jaakkola M.S., Samet J.M. Occupational Exposure to Environmental Tobacco Smoke and Health Risk Assessment. Environ. Health Persp. 1999;107;6:829-835. DOI: 10.1289/ehp.99107s6829.

6. Klein J., Koren G. Hair Analysis–a Biological Marker for Passive Smoking in Pregnancy and Childhood. Hum. Exp. Toxicol. 1999;18:279-282. DOI: 10.1191/096032799678840048.

7. Girod C., Staub C. Acetylcodeine as a Marker of Illicit Heroin in Human Hair: Method Validation and Results of a Pilot Study. J. Anal. Toxicol. 2001;25:106-111. DOI: 10.1093/jat/25.2.106.

8. Cizdziel J.V., Gerstenberger S. Determination of Total Mercury in Human Hair and Animal Fur by Combustion Atomic Absorption Spectrometry. Talanta. 2004;64:918-921. DOI: 10.1016/j.talanta.2004.04.013.

9. Revich B.A. Lead in Hair and Urine of Children and Adults from Industrialized Areas. Arch. Environ. Health. 1994;49:59-62. DOI: 10.1080/00039896.1994.9934416.

10. Bustueva K.A., Revich B.A., Bezpalko L.E. Cadmium in the Environment of Three Russian Cities and in Human Hair and Urine. Arch. Environ. Health. 1994;49:284-288. DOI: 10.1080/00039896.1994.9937481.

11. Daniel K.G., Harbach R.H., Guida W.C., Dou Q.P. Copper Storage Diseases: Menkes, Wilsons, and Cancer. Front. Biosci. 2004;9:2652-2662. DOI: 10.2741/1424.

12. Di Donato P., Napolitano A. 1,4-Benzothiazines as Key Intermediates in the Biosynthesis of Red Hair Pigment Pheomelanins. Pigm. Cell Res. 2003;16:532-539. DOI: 10.1034/j.1600-0749.2003.00085.x.

13. Greco G., Panzella L., Verotta L., d’Ischia M., Napolitano A. Uncovering the Structure of Human Red Hair Pheomelanin: Benzothiazolylthiazinodihydroisoquinolines as Key Building Blocks. J. Nat. Prod. 2011;74:675-682. DOI: 10.1021/np100740n.

14. Costin G.-E., Hearing V.J. Human Skin Pigmentation: Melanocytes Modulate Skin Color in Response to Stress. FASEB J. 2007;21:976-994. DOI: 10.1096/fj.06-6649rev.

15. Sealy R.C., Hyde J.S., Felix C.C., Menon I.A., Prota G. Eumelanins and Pheomelanins: Characterization by Electron Spin Resonance Spectroscopy. Science. 1982;217;4559:545-547. DOI: 10.1126/science.6283638.

16. Chikvaidze E., Khachatryan I. ESR Study of Photoinduced Free Radicals by Visible Light in Hair and the Effects of Ascorbic Acid (Vitamin C). Int. J. Cosmet. Sci. 2011;33:322-327. DOI: 10.1111/j.1468-2494.2010.00628.x.

17. Şeyda Çolak, Turan Özbey. An ESR Study on Biological Dosimeters: Human Hair. Rad. Meas. 2011;46;5:465-472. DOI: /10.1016/j.radmeas.2010.12.002.

18. Trevedi A., Greenstock C.L. Use of Sugars and Hair for ESR Emergency Dosimetry. Appl. Radiat. Isot. 1993;44:85-90. DOI: 10.1016/0969-8043(93)90201-k.

19. Tepe Çam S., Polat M., Seyhan N. The Use of Human Hair as a Biodosimeter. Appl. Radiat. Isot. 2014;94:272-281. DOI: 10.1016/j.apradiso.2014.08.021.

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The author declare no conflict of interest.

Financing. The work was carried out within the framework of state contract No. 11.310.19.2 on the topic “Improving the provision of emergency preparedness and response of the South Ural Regional Medical and Dosimetric Emergency Center in the event of radiation accidents” (code “Response-19”), funded by the Federal Medical and Biological Agency of Russia. EPR measurements were partly carried out within the framework of the state order of the Ministry of Education and Science of Russia (topic "Spin", No. AAAA-A18-118020290104-2).

Contribution. Article was prepared with equal participation of the authors

Article received: 15.03.2022.  

Accepted for publication: 23.04.2022