Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1

DOI: 10.33266/1024-6177-2023-68-1-58-71

O.K. Kurpeshev

Threshold Thermal Dose of Local Hyperthermia in Thermoradiation Therapy of Tumors

Siberian Scientific Research Institute of Hyperthermia, Novosibirsk

Contact person: Orazakhmet Kurpeshev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.



The review analyzes the damaging, radio- and chemosensitizing effects of various temperature regimes of hyperthermia on normal and tumor cells in the experiment and on the results of thermoradiation therapy for cancer patients. According to the criteria of minimum, average and maximum temperatures, as well as the cumulative equivalent time for heating 90 % of the tumor volume at 43 °C (CEM43T90), lower threshold thermal doses have been determined that significantly affect the immediate results of thermoradiation therapy. The maximum allowable temperatures for normal skin and with postoperative scars or radiation fibrosis have been established.

Keywords: hyperthermia, thermal dose, chemotherapy, thermoradiotherapy, thermochemotherapy. thermochemoradiotherapy

For citation: Kurpeshev OK. Threshold Thermal Dose of Local Hyperthermia in Thermoradiation Therapy of Tumors. Medical Radiology and Radiation Safety. 2023;68(1):58–71. (In Russian). DOI: 10.33266/1024-6177-2023-68-1-58-71



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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.09.2022. Accepted for publication: 25.11.2022.