Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2


Lina Alhaddad1,2, Andreyan N. Osipov1,3, Sergey Leonov1,4

Radiation-Induced Premature Senescence of Tumor Cells

1School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Russia

2Department of Environmental Sciences, Faculty of Science, Damascus University, Damascus, Syria

3A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

4 Institute of Cell Biophysics, Pushchino, Russia

Contact person: Andreyan N. Osipov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.




Factors and mechanisms of Stress-Associated Secretory Phenotype (SASP)

Morphological and transcriptional signatures of SASP

Radiation-induced signaling pathways associated with premature senescence


Keywords: ionizing radiation, premature senescence, stress, tumor cells


For citation: Alhaddad L, Osipov AN, Leonov S. Radiation-Induced Premature Senescence of Tumor Cells. Medical Radiology and Radiation Safety. 2023;68(2):5–10. (In Russian). DOI: 10.33266/1024-6177-2023-68-2-5-10



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Conflict of interest. The authors declare no conflict of interest.

Financing. The work was carried out with the financial support of RFBR grant No. 20-34-90035.

Contribution. L. Alkhaddad – collection and analysis of literary material, writing the text. A.N. Osipov and S.V. Leonov – concept development and scientific editing.

Article received: 20.11.2022. Accepted for publication: 25.01.2023.