Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2

DOI: 10.33266/1024-6177-2023-68-2-35-52

A.V. Ivanchenko¹, V.A. Basharin², I.S. Drachev¹, A.B. Seleznev¹, A.Y. Bushmanov³

To the Question about Pharmacological Protection during Irradiation in Non-Infecting Doses: Maybe, Necessary? 

Communication 3. Review of the Experience of Studying and Prospects for the Use of Anti-Radiation Medicines

¹Scientific Research Testing Institute of Military Medicine, St. Petersburg, Russia

² S.M. Kirov Military Medical Academy, St. Petersburg, Russia

³A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Alexander Ivanchenko, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Purpose: Review and systematization of data on the development of studies of drugs intended for protection against radiation in medium doses, assessment of the latest proposals and directions of pharmacological influence on radiation effects, incitement to discussion on the issue under consideration.

Results: An analysis of domestic and foreign literature for the period of the 70–90s of the twentieth century and the latest period in relation to the prevention of tissue reactions and long-term effects of low-dose low-power irradiation was carried out, classes (groups) and samples of pharmaceuticals used were considered.

Conclusions: 1. Very diverse previously proposed pharmaceuticals are still suitable, acting on various mechanisms of the genesis of the consequences of exposure to medium doses. 2. In recent years, substances (drugs) with receptor action, including genetically engineered products, as well as gene therapy agents, have been of primary interest, but they have been little studied as the means of choice due to their status as demonstration samples for use at medium doses. 3. Drugs of choice, made on the basis of many considerations over 30 years ago, until a replacement not be found.

Keywords: antiradiation agents, pharmacological agents and preparations, systematics, possibilities of use in case of irradiation in medium doses, analysis of the latest proposals, debatability of application

For citation: Ivanchenko AV, Basharin VA, Drachev IS, Seleznev AB, Bushmanov AY. To the Question about Pharmacological Protection during Irradiation in Non-Infecting Doses: Maybe, Necessary? Communication 3. Review of the Experience of Studying and Prospects for the Use of Anti-Radiation Medicines. Medical Radiology and Radiation Safety. 2023;68(2):35–52. (In Russian). DOI: 10.33266/1024-6177-2023-68-2-35-52

 

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.11.2022. Accepted for publication: 25.01.2023.