Medical Radiology and Radiation Safety. 2023. Vol. 68. № 4
DOI: 10.33266/1024-6177-2023-68-4-75-80
V.I. Kobylyansky1, T.V. Kudasheva2, M.G. Berezina2, T.M. Magomedov3
Studying the Aerodynamic Characteristics of the Macrotech
and Evaluation of the Possibilities of Its Use for Dynamic Aerosol Scintigraphy
1 Research Institute of Pulmonology, Moscow, Russia
2 Federal Scientific and Clinical Center, Moscow, Russia
3 Russian Research Institute of Physical, Technical and Radio Engineering Measurements, Zelenograd, Moscow region, Russia
Contact person: V.I. Kobylyansky, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction: The leading protective mechanism of the lungs is the processes of deposition of inhaled substances and mucociliary clearance (MCC), the optimal method for studying which is dynamic radioaerosol scintigraphy. are not available on the market. The applicant in this regard for a number of characteristics is the radiopharmaceutical from albumin, produced in the Russian Federation under the brand name Macrotech (M). It is used for perfusion scintigraphy to verify primarily pulmonary embolism and its ability to study deposition of inhalants and MCC has not been studied.
Purpose: To study the aerodynamic properties of M dispersion and to determine the possibilities of its use for dynamic radioaerosol scintigraphy of the lungs in order to assess the processes of deposition of inhaled substances and MCC.
Material and methods: To study the aerodynamic properties of M, on which the assessment of the deposition of inhaled substances and MCC significantly depends, we studied the dispersion of its particles in different states, and studied them in shape and morphology. An ultrasonic inhaler TuR USI-50 (Germany) generated an aerosol from a suspension of M in distilled water. To study the dispersion in air, laser spectrometry was used using the Spraytec Malvern Instruments system (Great Britain). The protein content in the initial suspension and dispersible aerosol, collected in the form of a condensate, was determined using an Immulite 2000 XPi immunochemical analyzer (Siemens, USA).The shape and morphology of the particles were studied using scanning electron microscopy using.
Results: The study of the aerodynamic properties of the dispersion of M indicated that its particles are involved in the dynamics of the movement of the airflow and the flight of water particles generated by the inhaler. The dispersity of the aerosol generated from the suspension M averaged about 5 μm and did not significantly depend on the concentration of the radiopharmaceutical and did not depend on the studied dispersion intensity and airflow rate set using an inhaler. The morphology of M particles was characterized by a complex shape and roughness.
Conclusion: The aerodynamic characteristics of M are not optimal for studying the processes of deposition and MCC. However, a final verdict requires a direct assessment of the deposition of the inhaled radioaerosol generated from this preparation.
Keywords: dynamic aerosol scintigraphy, albumin macroaggregates, macrotech, dispersion aerosol, shape and morphology of particles, inhalant deposition, mucociliary clearance
For citation: Kobylyansky VI, Kudasheva TV, Berezina MG, Magomedov TM. Studying the Aerodynamic Characteristics of the Macrotech and Evaluation of the Possibilities of Its Use for Dynamic Aerosol Scintigraphy. Medical Radiology and Radiation Safety. 2023;68(4):75–80. (In Russian). DOI:10.33266/1024-6177-2023-68-4-75-80
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2022. Accepted for publication: 27.03.2023.