Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1


I.O. Tomashevsky, O.S. Kornikova 

The Impotance of SPECT/CT in Simultaneous Assessment
of Calcinosis of Coronary Arteries, Perfusion and Contractile Function of the Myocardium among Females with Coronary Heart Disease

Central Clinical Hospital RZD-Medicine, Moscow, Russia

Contact person: Igor Ostapovich Tomashevsky, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.



Purpose: To study the frequency of calcinosis of coronary arteries and its effect on myocardial perfusion and contractile function among females with coronary heart disease (CHD).

Material and methods: A survey was conducted among 141 females with coronary heart disease (CHD): simultaneous assessment of coronary artery calcinosis, perfusion and contractile function with 99m Tc-technetril SPECT/CT with ECG-synchronization and X-ray radiation correction, as well as comparison of data with the results of electrocardiography (ECG), echocardiography (ECHO-CG), clinical and biochemical blood tests.

Results: Coronary artery calcinosis was detected in 33 (23 %) females with coronary heart disease (CHD) out of all patients identified: over the age of 55 years (M = 67 years with variations from 58 to 83 years) ‒ in 25 (17.7 %), aged 41‒55 years (M = 50 years with variations from 46 to 54 years) ‒ in 7 (4.6 %), at the age of 25‒40 years ‒ in one female 35 years (0.7 %). The Agatston calcium score interval was set as follows: at the maximum degree > 400 ‒ for 6 females (4.2 % of all surveyed); at 101‒400 ‒ in 9 (6.4 %); at 11‒100 ‒ in 17 (12.0 %); at 1‒10 ‒ in one female (0.7 %); with a minimum degree of 0 ‒ in 108 females (76.7 % of all surveyed). In the presence of maximum degree of calcinosis (> 400 units), a slight significant decrease in perfusion, an increase in ejection fraction and diastole duration was revealed.

Conclusion: The use of combined SPECT/CT with ECG synchronization and CT radiation correction technology in 141 females with coronary artery disease made it possible to identify coronary artery calcinosis in 23 % of patiets.

Keywords: females, coronary heart disease, SPECT/CT, myocardium, calcinosis of coronary arteries, perfusion, contractile function of the myocardium

For citation: Tomashevsky IO, Kornikova OS. The Impotance of SPECT/CT in Simultaneous Assessment of Calcinosis of Coronary Arteries, Perfusion and Contractile Function of the Myocardium among Females with Coronary Heart Disease. Medical Radiology and Radiation Safety. 2024;69(1):88–91. (In Russian). DOI:10.33266/1024-6177-2024-69-1-88-91



1. Tereshchenko S.N., Kobalava Zh.D., Moiseнev V.S., et al. Structural and Functional State of the Heart and the Effectiveness of the ACE Inhibitor Perindopril in Patients with Heart Failure Depending on the Polymorphism of the ACE Gene. Kardiologiia = Kardiologiya. 2000;1:35–37 (In Russ.).

2. Cannon R.O. Microvascular Angina and the Continuing Dilemma of Chest Pain with Normal Coronary Angiograms. J. Am. Coll. Cardiol. 2009;54:877–885.

3. Cannon P.J., Dell R.B., Dwyer E.M.Jr. Measurement of Regional Myocardial Perfusion in Man with 133 Xenon and a Scintillation Camera. J. Clin. Invest. 1971;51:964–977.

4. Campisi R. Noninvasive Assessment of Coronary Microvascular Function in Women at Risk for Ischemic Heart Disease. Int. J. ClinPract. 2008;62;2:300–307.

5. Collet J.P., Thiele H., Barbato E., et al. 2020 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-Segment Elevation. Eur. Heart. J. 2021;42:1289-1367. 

6. Ansheles A.A., Shulgin D.N., Solomyanyy V.V., Sergiyenko V.B. Comparison of the Results of Stress Tests, Data from Single-Photon Emission Computed Tomography of the Myocardium and Coronary Angiography in Patients with Coronary Heart Disease. Kardiologicheskiy Vestnik = Russian Cardiology Bulle. 2012;7;2:10-16 (In Russ.).

7. Lishmanov Yu.B., Chernov V.I. Natsionalnoye Rukovodstvo po Radionuklidnoy Diagnostike = National Guidelines for Radionuclide Diagnostics. Tomsk Publ., 2010 (In Russ.).

8. Oganov R.G., Fomina I.G. Bolezni Serdtsa = Heart Disease: A Guide for Doctors. Moscow, Litterra Publ., 2006. P. 1225-1242 (In Russ.).

9. Rudoy A.S., Zagashvili I.V. Microvascular Angina. Voyennaya Meditsina. 2013;1:143–148 (In Russ.).

10. Xiaoliang Shao, Xiaoliang Shao, Yuetao Wang, Ruijue Zhou, Jianfeng Wang. Characteristics of Coronary Artery Calcium in Chinese Patients with Suspected Coronary Artery Disease and Its Relationship with Myocardial Ischemia. Journal of Nuclear Medicine. 2016;57;2:339.



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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. I.O. Tomashevsky took part in the development of the concept, design, theoretical basis, modification of research methods. O. Kornikova took part in the collection and analysis of literary material, statistical data processing, writing and scientific editing of the text.

Article received: 20.10.2023. Accepted for publication: 27.11.2023.