Medical Radiology and Radiation Safety. 2024. Vol. 69. № 4

DOI:10.33266/1024-6177-2024-69-4-48-54

F.S. Torubarov, M.V. Kuleshova, N.A. Metlyaeva, S.N. Lukyanova

Studying the State of the Autonomic Nervous System and Hemodynamics in the Liquidators of the Accident
at the Chernobyl NPP

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: N.A. Metlyaeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT

Purpose: Comparative analysis of changes in the state of the autonomic nervous system and hemodynamics in liquidators of the consequences of the Chernobyl accident and individuals in the comparison group exposed to low doses of ionizing radiation.

Material and methods: The study was carried out for 141 liquidators of the consequences of the Chernobyl accident and 84 male comparison group people aged from 30 to 50 years (41.24 ± 0.41) and (40.95 ± 0.54), respectively. Only liquidators could be exposed to ionizing effects. All of them, the dose of ionizing radiation did not exceed 0.5 Gy. All individuals underwent a clinical, neurological and electrophysiological examination in A.I. Burnazyan Federal Medical Biophysical Center. The main attention was paid to studying the state of the autonomic nervous system and hemodynamics in participants in the liquidation of the consequences of the Chernobyl accident.

Results: Clinical examination made it possible to diagnose neurological disorders in both groups in the form of: vegetative-vascular dystonia, neurocirculatory dystonia, dyscirculatory encephalopathy of various etiologies ‒ with a statistically significant predominance of their quantity and quality among liquidators. The changes observed in liquidators are functional and nonspecific.

Conclusions: In the group of liquidators, a significant increase in the number and severity of the considered neurological disorders was revealed. Comparison of the examined groups according to the state of central hemodynamics showed the absence of a statistically significant connection between the state of cerebral blood flow and low-dose irradiation. At the same time, a connection was established between the state of cerebral hemodynamics and systemic autonomic tone and the age of the examined individuals. The combination of permanent and paroxysmal autonomic disorders, psychosomatic disorders can be considered as a manifestation of hypothalamic dysfunction that has developed against the background of vascular disorders in the brain that have arisen with age.

Keywords: accident at Chernobyl NPP, liquidators, autonomic nervous sistem, hemodynamics, functional diagnostics

For citation: Torubarov FS, Kuleshova MV, Metlyaeva NA, Lukyanova SN. Studying the State of the Autonomic Nervous System and Hemodynamics in the Liquidators of the Accident at the Chernobyl NPP. Medical Radiology and Radiation Safety. 2024;69(4):48–54.
(In Russian). DOI:10.33266/1024-6177-2024-69-4-48-54

 

References

1. Guskova AK, Soldatova VA, Denisova EA, et al. Long-term Consequences of Occupational Radiation Exposure. Meditsinskaya Radiologiya = Medical Radiology. 1976(4):34-40 (In Russ.).

2. Grigoriev Yu.G. Effects of Long-term Chronic Gamma Irradiation. Biologicheskiye Effekty Malykh Doz Radiatsii. Sbornik Nauchnykh Trudov = Biological Effects of Low Doses of Radiation: Collection of Scientific Papers. Moscow Publ., 1983. P. 11-20 (In Russ.).

3. Torubarov F.S. Kliniko-Fiziologicheskaya Kharakteristika Tserebral’noy Gemodinamiki pri OLB Cheloveka i yeye Posledstviyakh = Clinical and Physiological Characteristics of Cerebral Hemodynamics in Human Ars and its Consequences. Doctor’s thesis (Med.). Moscow Publ., 1983 (In Russ.).

4. Guskova A.K. Radiation: Imaginary and Real Dangers (Regulatory and Methodological Materials on Radiation Medicine of the USSR Ministry of Health). Moscow Publ., 1990. P. 5-11 (In Russ.).

5. Dakhno D.V. Izucheniye Sostoyaniya Vegetativnoy Nervnoy Sistemy u Lits, Prinimavshikh Uchastiye v Likvidatsii Posledstviy Avarii na CHAES = Study of the State of the Autonomic Nervous system in Persons Who Took Part in the Liquidation of the Consequences of the Chernobyl Accident. Doctor’s thesis (Med.). Moscow Publ., 1990. P. 145-154 (In Russ.).

6. Voloshin PV, Kryzhenko TV, Zdesenko IV. Clinical and Clinical-Physiological Features of Cerebrovascular Disorders in Persons Exposed to Radiation. Izmeneniye Nervnoy Sistemy Cheloveka pri Deystvii Ioniziruyushchey Radiatsii = Changes in the Human Nervous System under the Influence of Initiating radiation. Materials of the All-union Conference. Ed. F.S.Torubarov. Moscow Publ., 1990. P. 91-95 (In Russ.).

7. Gordon I.B, Gordon A.I. Tserebral’nyye i Perifericheskiye Vegetativnyye Rasstroystva v Klinicheskoy Kardiologii = Cerebral and Peripheral Autonomic Disorders in Clinical Cardiology. Moscow, Medicine Publ., 1994. P. 6-8 (In Russ.).

8. Ananyeva V.M. Psychovegetative Disorders in Persons Exposed to Relatively Low Doses of Radiation. Vserossiyskiy S”Yezd Nevrologov = All-Russian Congress of Neurologists: Abstracts of Reports. Nizhny Novgorod Publ., 1995. P. 520-521 (In Russ.).

9. Torubarov FS, Kuleshova MV, Lukyanova SN, Zvereva ZV, Samoilov AS. Spectral-Correlation Analysis of EEG in Liquidators of the Chernobyl Accident with Neurological Disorders. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2019;64(3):40-45 (In Russ.).

10. Baranov AE, Guskova AK, Protasova TG. Experience in Treating Victims of the Accident at the Chernobyl Nuclear Power Plant and Immediate Outcomes of the Disease. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 1991;36(3):29-32 (In Russ.)

11. Bushmanov A.Yu. Kliniko-Epidemiologicheskoye Issledovaniye Razvitiya Mozgovykh Insul’tov u Zhiteley Zakrytogo Administrativno-Territorial’nogo Obrazovaniya Zapadnoy Sibiri (g. Seversk) = Clinical and Epidemiological Study of the Development of Cerebral Strokes in Residents of a Closed Administrative-Territorial Entity of Western Siberia (Seversk). Doctor’s thesis (Med.). Moscow Publ., 1997. P. 34-38 (In Russ.).

12. Guskova AK. Ten Years After the Chernobyl Accident (Retrospective of Clinical Events and Measures to Overcome the Consequences). Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 1997:42(1):5-12 (In Russ.).

13. Guskova AK, Denisova EA. Basic Physiological Indicators of the Cardiovascular System of Practically Healthy People. Fiziologiya Cheloveka = Human Physiology. 1975(2):302-309 (In Russ.).

14. Guskova A.K., Shakirova I.N. Reaction of the Nervous System to Damaging Ionizing Radiation. Review. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry. 1989:89(2):138-142 (In Russ.).

15. Guskova AK, Yarmoninko SP. Essay on the Radiation Effects of the Atomic Bombing. Review. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 1995:40(6):67-69 (In Russ.)

16. Denisova E.A. Sostoyaniye Serdechno-Sosudistoy Sistemy pri Khronicheskom Luchevom Vozdeystvii v Professional’nykh Usloviyakh = State of the Cardiovascular System during Chronic Radiation Exposure in Professional Conditions. Doctor’s thesis (Med.). Moscow Publ., 1970. 425 p. (In Russ.).

17. Serdechno-Sosudistaya Sistema pri Deystvii Professional’nykh Faktorov = Cardiovascular System under the Influence of Professional Factors. Ed. N.M. Konchalovskaya. Moscow Publ., 1976. 256 p. (In Russ.).

18. Ternov V.I. Gigiyenicheskaya Znachimost’ Vozdeystviya na Organizm Ioniziruyushchey Radiatsii Maloy Intensivnosti (Naturnyye i Eksperimental’no-Laboratornyye Issledovaniya) = The Hygienic Significance of the Impact on the Body of Low-intensity Ionizing Radiation (Field and Experimental Laboratory Studies). Moscow Publ., 1986. 43 p. (In Russ.).

19. Barbarenko N.I, Denisova E.A, Pavlova I.V. Functional State of the Sympathetic-Adrenal System during Occupational Exposure. Meditsinskaya Radiologiya = Medical Radiology. 1975;(9):46-52 (In Russ.).

20. Guskova A.K. Using Medical Observation Data of Workers Working with Radiation Sources to Substantiate the “Risk” of Occupational Exposure. Meditsinskaya Radiologiya = Medical Radiology. 1980(11):41-46 (In Russ.).

21. Guskova A.K, Denisova E.A, Seltser V.K., et al. Results of Clinical and Physiological Observations of Persons Exposed to Occupational Exposure. Meditsinskaya Radiologiya = Medical Radiology. 1975(9):36-46 (In Russ.).

22. Bolotnikov V.M, Mikhailov M.A, Nechaeva V.I., et al. Organization and Main Tasks of Dispensary Observation of Workers Working with Sources of Non-Ionizing Radiation. Rentgenologiya i Radiologiya = Radiology and Radiology. 1981(2):128-131 (In Russ).

23. Kiryushkin V.I, Guskova A.K, Kosenko N.M. Organization of Observation of a Limited Part of the Population in Conditions of Increased Exposure. Rukovodstvo po Organizatsii Meditsinskogo Obsluzhivaniya Lits, Podvergshikhsya Deystviyu Ioniziruyushchego Izlucheniya = Guidelines for the Organization of Medical Care for Persons Exposed to Ionizing Radiation. Moscow, Energoizdat Publ., 1981;(2):128-131 (In Russ.).

24. Zakharova A.V. On the Effect of Low Doses of Ionizing Radiation on the State of Some Hemodynamic Parameters in People Working at Accelerators. Izbrannyye Materialy Byulletenya Radiatsionnoy Meditsiny = Selected Materials Bulletin of Radiation Medicine. 1970;2:52-55 (In Russ.)

25. Vorobyov E.I, Stepanov R.P. Ioniziruyushcheye Izlucheniye i Krovenosnyye Sosudy = Ionizing Radiation and Blood Vessels. Moscow, Energoatomizdat Publ., 1985. 293 p. (In Russ.).

26. Zenkov L.R, Ronkin M.A. Funktsional’naya Diagnostika Nervnykh Bolezney = Functional Diagnosis of Nervous Diseases. Moscow, Meditsina Publ., 1982. 432 p. (In Russ.).

27. Mekhanizmy Sistemnoy Regulyatsii Mozga = Mechanisms of Systemic Regulation of the Brain. Ed. Rudakova K.V., Chirkova A.I. Gor’kiy Publ., 1978. P. 348-355 (In Russ.).

28. Sudakov K.V., Yumatov Ye.A., Ul’yaninskiy L.S. Systemic Mechanisms of Emotional Stress. 8-y Vsesoyuznyy S”Yezd Nevropatologov, Psikhiatrov i Narkologov = 8th All-Union Congress of Neuropathologists, Psychiatrists and Narcologists. Materials. 25-28 October, 1988, Moscow. Moscow, Institute of Normal Physiology named after. P.K.Anokhin Publ., 1988. V.3. Pp. 52-63 (In Russ.).

29. Pribylova N.N., Koren V.S, Sidorets V.M, Beznosov N.S, Fomin A.V., Neronov A.F. Features of Neurocirculatory Dystonia under the Influence of Ionizing Radiation. Vsesoyuznaya Nauchnaya Konferentsiya = All-Union Scientific Conference 30-31 May, 1989. Moscow Publ., 1989. P. 67-74 (In Russ.).

 

 

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.03.2024. Accepted for publication: 25.04.2024.