Medical Radiology and Radiation Safety. 2025. Vol. 70. № 2
DOI:10.33266/1024-6177-2025-70-2-5-8
S.A. Abdullaev1, 2, N.F. Raeva1, D.V. Fomina1, T.P. Kalinin3,
T.N. Maksimova4, G.D. Zasukhina1, 5
Thymoquinone (a Component of Nigella Sativa) Reduces Toxic Effects of Radiotherapy and Has Anti-Cancer Potential
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 Institute of Theoretical and Experimental Biophysics, Pushchino, Russia
3 N.I. Pirogov Russian National Research Medical University, Moscow, Russia
4 I.M. Sechenov First Moscow State Medical University, Moscow, Russia
5 N.I. Vavilov Institute of General Genetics, Moscow, Russia
Contact person: S.A. Abdullaev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The review analyzes literature data on the biological properties of thymoquinone (TQ), a component of black cumin (Nigella sativa), which is widely used (mainly in the East) for the prevention and treatment of a number of pathologies, including oncology. Numerous data are provided on the radioprotective properties of TQ on experimental animals associated with the effect on oxidative stress induced by radiation, as well as stimulation of the protective systems of the cell and the body. The effect of TQ in combination with radiation in tumor formation is shown. Given the safety of TQ compared to synthetic protectors, the authors recommend TQ for further research for prevention and treatment of radiation exposure.
Keywords: thymoquinone, radioprotector, antioxidant, radiotherapy
For citation: Abdullaev SA, Raeva NF, Fomina DV, Kalinin TP, Maksimova TN, Zasukhina GD. Thymoquinone (a Component of Nigella Sativa) Reduces Toxic Effects of Radiotherapy and Has Anti-Cancer Potential. Medical Radiology and Radiation Safety. 2025;70(2):5–8. (In Russian). DOI:10.33266/1024-6177-2025-70-2-5-8
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Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out on the topic of the Technology-3 Federal State Budgetary Educational Institution of Science and Technology named after A.I. Burnazyan (state assignment No. 123011300105-3).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.12.2024. Accepted for publication: 25.01.2025.