Medical Radiology and Radiation Safety. 2026. Vol. 71. № 5
DOI:10.33266/1024-6177-2026-71-5-150-156
P.K. Sitnikov¹, ², I.I. Anisenya¹, ², R.V. Zelchan¹, E.A. Usynin¹, V.I. Chernov¹, A.A. Medvedeva¹, D.O. Pakhmurin², ³, V.V. Pakhmurina²
POTENTIAL OF SPECT/CT IN THE DYNAMIC FOLLOW-UP OF PATIENTS WITH BONE TUMOR LESIONS AFTER RADICAL INTRAOPERATIVE THERMAL ABLATION: CLINICAL CASES
1 Tomsk National Research Medical Center, Tomsk, Russia
2 Tomsk State University of Control Systems and Radioelectronics, Tomsk, Russia
³ Siberian State Medical University, Tomsk, Russia
Contact person: P.K. Sitnikov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To demonstrate, using clinical examples, the potential of SPECT/CT at different stages of follow-up in patients with bone tumor involvement treated with radical intraoperative thermal ablation.
Material and methods: The paper presents two clinical cases of patients with bone tumors who underwent radical intraoperative thermal ablation developed at the Cancer Research Institute of the Tomsk National Research Medical Center (Tomsk NRMC). During follow-up, structural changes in bone after high-temperature exposure, as well as metal-related osteosynthesis artifacts, made imaging findings equivocal. To address these limitations, the extended capabilities of SPECT/CT using 9mTc-Pyrfotech were applied. Imaging was performed 3 hours after intravenous administration of the radiopharmaceutical on a Symbia Intevo Bold hybrid SPECT/CT system (Siemens) according to standard protocols. Quantitative assessment of radiotracer uptake in pathological foci was performed using the standardized uptake value (SUV).
Results: SPECT/CT enabled interpretation of indeterminate bone changes that, based on planar bone scintigraphy and spiral computed tomography, had been regarded as post-therapeutic.
Conclusion: The presented cases indicate that incorporating SPECT/CT into the diagnostic algorithm for patients with bone changes that are difficult to differentiate provides a reliable and objective assessment. This approach may be useful not only for improving differential diagnosis between benign and malignant bone alterations, but also for evaluating treatment efficacy.
Keywords: bone tumor lesions, radical intraoperative thermal ablation, SPECT/CT
For citation: Sitnikov PK, Anisenya II, Zelchan RV, Usynin EA, Chernov VI, Medvedeva AA, Pakhmurin DO, Pakhmurina VV. Potential of Spect/Ct in the Dynamic Follow-Up of Patients with Bone Tumor Lesions after Radical Intraoperative Thermal Ablation: Clinical Cases. Medical Radiology and Radiation Safety. 2026;71(5):150–156. DOI:10.33266/1024-6177-2026-71-5-150-156
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Conflict of interest. The authors declare no conflict of interest.
Financing. This study was funded by the Ministry of Science and Higher Education of the Russian Federation, project number FEWM-2024-0003.
Contribution. Pavel Sitnikov: development of the research concept, data collection and analysis, writing and editing of the manuscript; Ilya Ivanovich Anisenya: development of the research concept, critical editing with significant intellectual contribution; Evgeny Anatolyevich Usynin: data collection and analysis; Roman Vladimirovich Zelchan: data collection and analysis, critical editing with significant intellectual contribution, editing of the manuscript; Chernov Vladimir Ivanovich: critical editing with significant intellectual contribution, editing of the manuscript; Medvedeva Anna Aleksandrovna: data collection and analysis, critical editing with significant intellectual contribution, editing of the manuscript; Pakhmurin Denis Olegovich: data collection and analysis, administrative support of the project; Pakhmurina Victoria Viktorovna: data collection and analysis.
Article received: 20.04.2026. Accepted for publication: 25.05.2026.