Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 65-69

REVIEW

O.K. Kurpeshev¹, N.Yu. Florovskaiya²

The Results of Palliative Treatment of Colorectal Cancer Metastases to the Liver by Thermoradiotherapy

1.A.F. Tsyb Medical Radiological Research Centre, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Murmansk Regional Oncology Center, Murmansk, Russia

ABSTRACT

Purpose: Studying of efficiency of thermoradiation therapy in palliative treatment of patients with metastasises (MTS) of a colorectal cancer (CRC) in a liver.

Material and methods: Thermoradiotherapy therapy (TRT), held on 23 patients with CRC to the liver mts. Comparison group was 28 patients who underwent only external beam radiotherapy (EBRT). Locoregional hyperthermia of the liver was performed by a capacitive method at a temperature of 41-44 °C MTS and duration of exposure of 40 to 90 min. The total tumor dose EBRT in total liver irradiation was 20-26 Gy, subtotal - 28-36 Gy. The results of treatment were assessed by direct effect and overall survival according to stage (st.) liver disease.

Results: In the control group immediate therapeutic effect was detected in 13 (46 %) patients in the study - 17 (74 %), p = 0.044. The tendency to a difference (p = 0,06-0,07) in overall survival between subgroups of patients was with 2 and 3 stage liver disease. Patients with 2 stage median survival after EBRT were 7 months., TRT - 9 months, 3 stage - 3 and 4 months respectively.

Conclusion: The findings suggest the need for further research of thermoradiotherapy for the palliative treatment of patients with colorectal cancer to the liver MTS.

Key words: hyperthermia, radiation therapy, colorectal cancer, metastases in the liver

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For citation: Kurpeshev OK, Florovskaiya NYu. The Results of Palliative Treatment of Colorectal Cancer Metastases to the Liver by Thermoradiotherapy. Medical Radiology and Radiation Safety. 2016;61(2):65-9. Russian.

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