Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 1. P. 57-64


O.P. Trofimova, I.Y. Kubasova, I.V. Kolyadina, S.I. Tkachev, N.P. Shipilina, V.A. Khajlenko, A.A. Maklakova, I.M. Lebedenko

Experience of Accelerated Partial Breast Irradiation after Organ-Preserving Surgery in Patients with Early Breast Cancer in Brcc

Blokhin Russian Cancer Research Centre, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: To increase the radiation therapy efficacy in breast cancer patients.

Material and methods: The study included 53 patients with verified breast cancer in stages T1–2N0–micM0 treated in 2008–2013. The median age of the patients was 65 years. Median follow-up study for 30 months was conducted. The patients were undergone to organ-preserving treatment, including radical resection followed with accelerated partial radiation therapy. This method of radiation therapy was used in patients who were carefully selected accordingly to strict criteria. For a clear visualization and adequately determine the volume of the tissue irradiated in 92 % of patients the clipping of bed removed tumor was held using metal clips. All patients had conformal radiation therapy: 2,5 Gy twice a day, daily dose of 5 Gy, (for16 days) summary dose 40 Gy. The criteria of patients selecting to this method of radiation therapy and results of randomized controlled trials are described.

Results: Within a median follow-up study for 30 months, no local and loco-regional recurrences, as well as distant metastases were observed.

Conclusion: Proposed method of accelerated partial breast irradiation of patients with early breast cancer carefully selected shows the results comparable with those of the entire remaining breast exposure.

Key words: radiotherapy, breast cancer, local recurrens, accelerated partial irradiation