Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 53-61


L.I. Musabaeva1, V.A. Lisin1,2, Zh.A. Startseva1, O.V. Gribova1, V.V. Velikaya1, A.A. Melnikov1

Neutron Therapy on U-120 Cyclotron

1. Cancer Research Institute, Siberian Branch of the RAMS, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. National Research Tomsk Polytechnic University


The review is devoted to the 30-year neutron therapy experience in cancer treatment at the Tomsk Cancer Research Institute. In 1983, the Institute of Nuclear Physics affiliated to the Tomsk Polytechnic University was the first in Russia to perform radiation therapy with fast neutrons for cancer patients. Neutron therapy at the initial stage included the formation of the therapeutic fast neutron beam with the average energy of 6.3 MeV, dosimetric and radiobiological studies, clinical trials and accumulation of the own experience in the treatment of resistant tumors with fast neutrons. Efficacy of new methods of neutron and concurrent neutron-photon therapy, optimal regimens of combined modality treatment and independent radiation therapy were studied. The comprehensive programme on the prevention and treatment of acute radiation-induced complications and radiation damages to normal tissues and critical organs was developed.



Purpose of the study

Dosimetric and radiobiological studies

Clinical trials

Patterns of tumor reoxygenation in fast neutron therapy

Parotid salivary gland

Thyroid cancer

Neutron therapy for patients with locally advanced T2–4N0–2M0 breast cancer

Pathological tumor response to preoperative neutron therapy

Fast neutrons in the treatment of locally recurrent breast cancer

Cytogenetic studies in cancer patients who received neutron therapy


Key words: therapeutic channel, resistant tumor forms, neutron Therapy