SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

Медицинская радиология и радиационная безопасность. 2019. Том 64. № 3. С. 58–63

DOI: 10.12737/article_5cf3dfefe60b13.90120976

В.И. Чернов1, Е.А. Дудникова1, В.Е. Гольдберг1, Т.Л. Кравчук1, А.В. Данилова1, Р.В. Зельчан1, А.А. Медведева1, И.Г. Синилкин1, О.Д. Брагина1, Ю.В. Белевич1, Е.С. Королева2

Однофотонная эмиссионная компьютерная томография в диагностике и мониторинге лимфопролиферативных заболеваний

1. Томский национальный медицинский исследовательский центр РАН, Научно-исследовательский институт онкологии, Томск. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ;
2. Сибирский государственный медицинский университет, Томск

В.И. Чернов – зам. директора, зав. отделом, д.м.н., проф.;
Е.А. Дудникова – м.н.с.;
В.Е. Гольдберг – зам. директора, зав. отделением, д.м.н., проф.;
Т.Л. Кравчук – врач-гематолог, к.м.н.;
А.В. Данилова – врач-гематолог;
Р.В. Зельчан – врач-радиолог, к.м.н.;
А.А. Медведева – с.н.с., к.м.н.;
И.Г. Синилкин – с.н.с., к.м.н.;
О.Д. Брагина – врач-онколог, м.н.с., к.м.н.;
Ю.В. Белевич – м.н.с.;
Е.С. Королева – доцент, к.м.н.

Реферат

Несмотря на высокую эффективность применения ПЭТ с 18F-ФДГ в диагностике, стадировании, мониторинге и прогнозе лечения лимфопролиферативных заболеваний, применение этого метода в нашей стране ограничено из-за высокой стоимости исследования и недостаточного количества ПЭТ-центров. В связи с этим представляется актуальным проведение научных исследований, направленных на применение известных и разработку оригинальных радиофармпрепаратов (РФП) для визуализации лимфом методом однофотонной эмиссионной компьютерной томографии (ОФЭКТ). В данном обзоре рассмотрены основные РФП (67Ga-цитрат, 201Tl-хлорид, 199Tl-хлорид, 99mTc-метокси-изобутил-изонитрил, 99mTc-тетрофосмин, 111In-октреотид), применение которых возможно для визуализации лимфом с помощью ОФЭКТ. Проанализированы особенности их применения, механизмы действия, возможности их использования при различных морфологических вариантах и локализациях поражения. Представлены результаты применения инновационного РФП 99mTc-1-тио-D-глюкоза, который является перспективным для диагностики, стадирования и мониторинга лимфопролиферативных заболеваний.


Ключевые слова: лимфопролиферативные заболевания, лимфома Ходжкина, неходжкинские лимфомы, однофотонная эмиссионная компьютерная томография, 67Ga-цитрат, таллий-201, таллий-199, 99mTc-метокси-изобутил-изонитрил, 99mTc-тетрофосмин, 111In-октреотид, 99mTc-1-тио-D-глюкоза

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Для цитирования: Чернов В.И., Дудникова Е.А., Гольдберг В.Е., Кравчук Т.Л., Данилова А.В., Зельчан Р.В., Медведева А.А., Синилкин И.Г., Брагина О.Д., Белевич Ю.В., Королева Е.С. Однофотонная эмиссионная компьютерная томография в диагностике и мониторинге лимфопролиферативных заболеваний // Медицинская радиология и радиационная безопасность. 2019. Т. 64. № 3. С. 58–63.

DOI: 10.12737/article_5cf3dfefe60b13.90120976

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