SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

Медицинская радиология и радиационная безопасность. 2019. Том 64. № 3. С. 64–73

DOI: 10.12737/article_5cf3e4354d3276.60963732

Д.В. Кузьмичев1, З.З. Мамедли1, А.А. Анискин2, А.В. Полыновский1, Ж.М. Мадьяров1, С.И. Ткачев1, А.В. Егорова2, А.С. Анискина1

Эволюция неоадьювантного и адьювантного компонентов комплексного лечения больных местнораспространенным раком прямой кишки

1. Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина Минздрава РФ, Москва;
2. Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава РФ, Москва. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Д.В.Кузьмичев – с.н.с., к.м.н.;
З.З. Мамедли – зав. отделением, к.м.н.;
А.А. Анискин – ординатор;
А.В. Полыновский – н.с., к.м.н.;
Ж.М. Мадьяров – врач, к.м.н.;
С.И. Ткачев – в.н.с., д.м.н., проф.;
А.В. Егорова – к.м.н., проф.;
А.С. Анискина – ординатор

Реферат

Представлены результаты многочисленных одноцентровых и многоцентровых рандомизированных и нерандомизированных исследований, посвященных лечению пациентов с местнораспространенной формой рака прямой кишки (МРРПК) за 70-летний период. Репрезентирована последовательность хирургического, лекарственного, лучевого и химиолучевого лечения. Описаны дозы и объем лучевого воздействия как в монорежиме, так и с применением различных комбинаций химиотерапевтических препаратов в неоадьювантном и адъювантном режимах. Произошедшая эволюция комплексного лечения сместила акценты к использованию химиолучевой терапии в неоадъювантный период, а внедрение новых химиотерапевтических препаратов и режимов позволили значительно увеличить показатели выживаемости среди больных МРРПК. Подходы к лечению больных МРРПК не являются статичными и постоянно совершенствуются. В данном литературном обзоре отображена хронологическая последовательность и основные современные тенденции неоадъювантного и адъювантного компонентов лечения больных с местнораспространенной формой рака прямой кишки.

Ключевые слова: местнораспространенный рак прямой кишки, комплексное лечение, консолидирующая химиотерапия, индукционная химиотерапия, лечебный патоморфоз

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Для цитирования: Кузьмичев Д.В., Мамедли З.З., Анискин А.А., Полыновский А.В., Мадьяров Ж.М., Ткачев С.И., Егорова А.В., Анискина А.С. Эволюция неоадьювантного и адьювантного компонентов комплексного лечения больных местнораспространенным раком прямой кишки // Медицинская радиология и радиационная безопасность. 2019. Т. 64. № 3. С. 64–73.

DOI: 10.12737/article_5cf3e4354d3276.60963732

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