JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-96-104
S.M. Minin, Zh.Zh. Anashbayev, E.A. Samoylova, A.A. Zheravin,
W.Yu. Ussov, S.E. Krasilnikov, A.M. Cherniavsky
SPECT/CT with 99mTc-Technetryl in Staging, Planning of External Radiotherapy and Follow-up in Lung Cancer: a Clinical Case and Case – Addressed Review of Literature
E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia
Contact person: W.Yu. Ussov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
The case of a patient with newly diagnosed peripheral cancer of the right lung, involving the pleura, in whom the local extent of the process initially detected by X-ray CT was significantly extended from the data of the SPECT with 99mTc-technetryl. In particular, with SPECT/CT before the start of radiation therapy (RT), involved lymph nodes were detected both in the lower edge of the root of the right lung, and in paraaortic and paratracheal location. The SPECT/CT with 99mTc-technetryl was carried out with dual-detector gamma-camera GE Discovery NM/CT 670 DR (GE Medical) in a quantitative mode, with calibration and calculation of indexes of standardized uptake values (SUV) and % uptake of the administered activity by the primary tumor and metastatically involved lymph nodes. The values of the volume of tumor tissue were, respectively, for the tumor and the largest proximal metastatically involved lymph node 154.2 cm3 and 12.9 cm3, % of the activity absorbed by the tumor tissue − 0.498 and 0.030 %, and SVP ‒ 2.19 and 2.5.With subsequent external radiation therapy (in total 40 Gy, 2 Gy 5−6 times a week) the irradiation fields were planned in such a way that all affected lymph nodes were within their borders.
A control SPECT/CT study carried out immediately after the RT showed a decrease in the volume of tumor tissue in the primary node down to 58 cm3, % of the activity absorbed by the tumor tissue to 0.090 %, and SVP ‒ to 1.15. Reliable imaging of lymph nodes after LT was not observed. After 6.5 months, no evidencies for relapse or continued tumor growth were detected with a control X-ray CT performed on an outpatient visit with contrast enhancement.
Thus, SPECT/CT with 99mTc-technetryl in lung cancer is a vital method for clarifying the diagnosis and assessment of the extent of the tumor process, as well as monitoring the patient. A broad inter-center assessment of abilities of the SPECT/CT with 99mTc-technetryl in lung cancer is advisable, especially when planning RT.
Keywords: lung cancer, radiation therapy, dosimetric planning, SPECT/CT, 99mTc-technetryl
For citation: Minin SM, Anashbayev ZhZh, Samoylova EA, Zheravin AA, Ussov WYu, Krasilnikov SE, Cherniavsky AM. SPECT/CT with 99mTc-technetryl in Staging, Planning of External Radiotherapy and Follow-up in Lung Cancer: a Clinical Case and Case – Addressed Review of Literature. Medical Radiology and Radiation Safety. 2023;68(5):96–104. (In Russian). DOI:10.33266/1024-6177-2023-68-5-96-104
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.