JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-5-11
Yu.B. Deshevoi, V.G. Lebedev, T.A. Nasonova, O.A. Dobrynina,
A.S. Umnikov, T.A. Astrelina, A.S. Samoylov, V.Yu. Soloviev
Comparison of the Efficacy of Different Methods of Treatment
of Severe Local Radiation Injuries in an Experiment
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Yu.B. Deshevoi, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To compare the effectiveness of different methods of treating severe local radiation injuries (LRI) under the same experimental conditions.
Material and methods: Male rats of the Wistar-Kyoto inbred line were locally irradiated in the ilioplumbar region of the back using an X-ray unit LNK-268 at a dose of 110 Gy (tube voltage 30 kV, current 6.1 mA, Al filter 0.1 mm thick), at a dose rate of 20.0 Gy/min. The area of the irradiation field was 8.2 cm2. Such radiation exposure led to the occurrence of severe LRI in rats with long-term non-healing skin ulcers, without critical radiation exposure to the underlying tissues.
For the treatment of severe LRI, surgical methods, cell or drug therapy were used, which were used separately from each other. Treatment began on the 28th day after local irradiation, that is, during the period when the radiation ulcer had already formed and regenerative processes began to activate in the affected area. Various surgical approaches were used: from complete excision of the radiation ulcer to removal of various volumes of necrotic tissue within the radiation ulcer. Cell therapy consisted of transplantation of syngeneous cells of the stromal vascular fraction of adipose tissue or cultured syngeneous multipotent mesenchymal stromal cells. The cells were injected subcutaneously around the radiation ulcer twice at 1-week intervals. For drug therapy of severe local radiation injuries, we used a veterinary complex antibiotic ‒ levotetrasulfin forte, as well as drugs that affect the microcirculation and trophism of irradiated tissues – pentoxifylline and detralex. The drugs were used once a day from the 28th to the 49th day after irradiation.
Results and coclusion: The use of surgical methods, cell or drug therapy facilitated the course of the pathological process and accelerated the healing of radiation ulcers. However, different treatments for severe LRI have had different efficacy. In terms of the rate and quality of healing of severe local radiation injuries, drug therapy is less effective than cellular therapy, and cell therapy is less effective than complete surgical excision of radiation ulcers.
Keywords: radiation ulcer, surgical excision, transplantation, stromal-vascular fraction of adipose tissue, multipotent mesenchymal stromal cells, drug therapy, rats
For citation: Deshevoi YuB, Lebedev VG, Nasonova TA, Dobrynina OA, Umnikov AS, Astrelina TA, Samoylov AS, Soloviev VYu. Comparison of the Efficacy of Different Methods of Treatment of Severe Local Radiation Injuries in an Experiment. Medical Radiology and Radiation Safety. 2024;69(6):5–11. (In Russian). DOI:10.33266/1024-6177-2024-69-6-5-11
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.