JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2026. Vol. 71. № 2
DOI:10.33266/1024-6177-2026-71-2-26-32
T.V. Azizova, M.B. Moseeva, E.S. Grigoryeva
Analysis of Cerebrovascular Disease Incidence Risk
in the Cohort of Mayak Production Association Workers
Southern Urals Federal Medical Biophysics Research Centre, Ozyorsk, Russia
Contact person: T.V. Azizova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To estimate cerebrovascular disease (CeVD) incidence risk in the cohort of Mayak Production Association (PA) workers occupationally chronically exposed to ionizing radiation.
Material and methods: Study cohort included 22237 Mayak PA workers. Information about occupational history as well as external gamma- and internal alpha-radiation doses absorbed in liver were obtained from the “Mayak Workers Dosimetry System – 2013”. Medical data and data on risk factors as of the end of 2018 were obtained from the “Clinic” medical dosimetry database. Relative risk (RR) and excess RR (ERR) per unit of external or internal dose adjusted for other factors were estimated by the maximum likelihood method using AMFIT module of EPICURE software.
Results: 9469 cases of CeVD (I60–I69 ICD-10 codes) were identified during the follow-up period. Analysis revealed ERR per 1 Gy of external gamma-radiation dose absorbed in liver statistically significantly above zero: 0.37 (95 % confidence interval, CI, 0.27–0.47) among males and 0.47 (95 % CI 0.31–0.66) among females over the whole dose range. ERR/Gy estimate for external exposure statistically significantly decreased with increasing workers’ attained age (males and females) and with increasing employment duration (females). Estimates of ERR per 1 Gy of internal alpha-radiation dose absorbed in liver were also statistically significantly above zero, i.e. 0.31 (95 % CI 0.10–0.59) among males and 0.32 (95 % CI 0.11–0.61) among females over the whole dose range. There were no heterogeneity between ERR/Gy estimates for CeVD incidence in relation to internal exposure dose between attained age groups either among males or females. While there were heterogeneity in ERR/Gy estimates for CeVD incidence in relation to employment duration in the whole cohort and among females; at this ERR/Gy for internal exposure among females statistically significantly decreased with increasing employment duration. It was shown that risk estimate was significantly influenced by the adjustment for another dose in case of combined exposure and to a lesser extent by the adjustments for non-radiation factors.
Conclusion: The present study of Mayak PA workers revealed statistically significant relationship between CeVD incidence and total external gamma-radiation or internal alpha-radiation dose absorbed in liver.
Keywords: cerebrovascular diseases, risk, incidence, chronic occupational radiation exposure, PA Mayak
For citation: Azizova TV, Moseeva MB, Grigoryeva ES. Analysis of Cerebrovascular Disease Incidence Risk in the Cohort of Mayak Production Association Workers. Medical Radiology and Radiation Safety. 2026;71(2):26–32. (In Russian). DOI:10.33266/1024-6177-2026-71-2-26-32
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.01.2026. Accepted for publication: 25.02.2026.