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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2026. Vol. 71. № 2

DOI:10.33266/1024-6177-2026-71-2-69-80

W.Yu. Ussov1, M.L. Belyanin2, E.V. Barysheva3, A.A. Tulupov4, 10, Li Yong Ping5,
O.Y. Borodin6, Shan YaMing5, S.M. Minin1, K.N. Sorokina6, Yu.B. Lishmanov2,
O.P. Aleksandrova7, 8, Zhou Jianghan11 N.L. Shimanovsky9 

Pharmacokinetic Analysis of Accumulation of Gluconic Acid Complexes with 99mTc and Mn(II) in Gliomas and Metastatic Brain Lesions, using Dynamic Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography

1 E.N. Meshalkin National Research Medical Center, Novosibirsk, Russia

2 National Research Tomsk Polytechnic University, Tomsk, Russia 

3 JSC Medical and Diagnostic Center, Tomsk, Russia 

4 Institute “International Tomographic Center”, Novosibirsk, Russia 

5 Changchun Sino-Russian Science and Technology Park Co., Ltd, Changchun, China

6 Tomsk Regional Oncological Dispensary, Tomsk, Russia 

7 National Research Nuclear University MEPhI, Moscow, Russia 

8 Rosatom Technical Academy, Obninsk, Russia 

9 N.I. Pirogov Russian National Medical Research University, Moscow, Russia 

10 Novosibirsk State University, Novosibirsk, Russia

11 School of Life Sciences, Jilin University, Changchun, China

Contact person: Wladimir Yuryevich Ussov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

Relevance: A promising direction for the successful development of diagnostic tomography is the creation of pairs of paramagnetic contrasts for MRI and radiopharmaceuticals for SPECT with identical biological and pharmacokinetic properties. Comparing the results of contrast-enhanced MRI and SPECT scans could provide then fundamentally new information. 

Purpose: To evaluate the imaging abilities of 99mTc-gluconate as an RFP for SPECT/CT, in comparison with Mn-gluconate (for paramagnetic contrast enhancement in MRI), in the course of creation of a new generation of diagnostic agents for combined SPECT/MRI studies of brain tumors. 

Material and methods: 99mTc-gluconate was obtained by labeling for 30 minutes, at room temperature above 25°C, 370‒540 MBq of Technetium ‒ 99m eluate in a volume of 2‒4 ml, from a 99Mo/99mTc generator, while the lyophilized labeling kit included 2.5 mg of gluconic acid, 0.10 mg of SnCl2×2H2O as a reducing agent, 7.5 mg sodium hydrophosphate dodecahydrate and 1.5 mg ascorbic acid. Mn(II)-gluconate was obtained in one step from manganese(II) oxide or carbonate and gluconic acid or sodium gluconate, with their mixing in molar amounts in a ratio of 1:2, dispersion and stirring in a ball mill for 20‒30 minutes, dissolution in saline solution, sterilization by microfiltration and obtaining 0.5 M solution of Mn(II)-gluconate, pH 6.5‒7.8, The study comprised the results of an examination of nine patients with low-grade (3‒4 degrees of anaplasia) brain gliomas, one patient with meningioma of the middle cranial fossa, and three patients with brain metastases (kidney, lung, and breast cancers). All underwent SPECT with 99mTc-gluconate on a Gemini dual-detector gamma camera (Technicare, USA), controlled by the Scinti 3.3 computer system (NPF Gelmos, Russia) after the injection of 370‒540 MBq of the RFP. A dynamic planar study was recorded after injection, for 20 minutes, with blood samples taken to assess the clearance of rfp. SPECT then included 64‒128 planar projections of 360° rotation detectors with a set of 50,000 pulses each, in a 64 × 64 matrix. The rate of absorption of rfp and paramagnetic substances by tumors and the indices (Tumor)/(Healthy tissue) were calculated. The rate of absorption of the drug by the tumor was calculated as the ratio of the concentration in the tumor tissue to the area under the concentration curve in the blood. 

Results: The rate of contrast  absorption from blood to tumor was 6.72 ±2.01 (3.5; 12.1) ml/min/100 g for 99mTc-gluconate and 5.93 ± 2.95 (3.2; 10.1) ml/min/100 g for Mn-gluconate for peripheral gliomas, the correlation between them was highly reliable, as Y = ‒0,14 + 0,89×X (r = 0.89, p = 0.000372). The unaffected gray matter of the brain showed an order of magnitude lower absorption rate from the blood, respectively 0.20 ±0.09 (0.07; 0.41) ml/min/100 g of 99mTc-gluconate and 0.23 ± 0.12 (0.05; 0.49) ml/min/100 g for Mn-gluconate. Indexes (Tumor)/(Healthy tissue) were 15.2 ± 3.28 (11.19; 21.23) for 99mTc-gluconate and 11.28 ± 9.80 (2.4; 30.26) for Mn-gluconate, with the correlation equation Y = 0.74 + 0.67×X (r = 0.94, p = 0.00684), indicating the biological identity of these complexes. 

Conclusion: The results of the assessment of tumor accumulation of gluconic acid complexes with 99mTc- and Mn substantiate the possibility of wider use in neuro-oncology of rfp 99mTc-gluconate in SPECT and Mn-gluconate in MRI as a paramagnetic analogue of 99mTc-gluconate, with high affinity to brain tumors, and possibility of MRI/SPECT fused studies.

Keywords: SPECT/CT, MRI, radiopharmaceuticals, 99mTc-gluconate, Mn-gluconate, paramagnetic contrast enhancement, pharmacokinetics, neuro-oncology, gliomas, meningeomas, brain metastases

For citation: Ussov WYu, Belyanin ML, Barysheva EV, Tulupov AA, Li Yong Ping, Borodin OY, Shan YaMing, Minin SM, Sorokina KN, Lishmanov YuB, Aleksandrova OP, Zhou Jianghan Shimanovsky NL.  Pharmacokinetic Analysis of Accumulation of Gluconic Acid Complexes with 99mTc and Mn(II) in Gliomas and Metastatic Brain Lesions, using Dynamic Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography. Medical Radiology and Radiation Safety. 2026;71(2):69–80. DOI:10.33266/1024-6177-2026-71-2-69-80

 

References

  1. Tyurin I.Ye. Radiation Diagnostics in the Russian Federation. Onkologicheskiy Zhurnal: Luchevaya Diagnostika, Luchevaya Terapiya = Journal of Oncology: Diagnostic Radiology and Radiotherapy. 2018;1;4:43-51 (In Russ.). EDN QZSWYK.
  2. Gordeyev A.D., Korostovtseva L.S., Amelina V.V., Zabroda Ye.N., Bochkarev M.V., Ryzhkova D.V. Glucose Metabolism and Brain Perfusion. Translyatsionnaya Meditsina = Translational Medicine. 2025;12;2:182-188 (In Russ.). Doi: 10.18705/2311-4495-2025-12-2-182-188. EDN: DVOJGD
  3. Minin S.M., Anashbayev Zh.Zh., Samoylova Ye.A., Zheravin A.A., Usov V.Yu., Krasil’nikov S.E. SPECT/CT with 99mTc-Technetrile in Assessing the Prevalence, Planning and Monitoring of Radiation Therapy for Lung Cancer. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2023;68;5:96–104 (In Russ.). Doi: 10.33266/1024-6177-2023-68-5-96-104.
  4. Denisova N.V., Gurko M.A., Minin S.M., Anashbayev Zh.Zh., Zheravin A.A., Samoylova Ye.A. Possibilities of Computer Modeling of Tumor Lesions of the Lungs when Compared with SPECT/CT Data with 99mTc-MIBI. Sibirskiy Onkologicheskiy Zhurnal = Siberian Journal of Oncology. 2023;22;2:14-25 (In Russ.). Doi: 10.21294/1814-4861-2023-22-2-14-25.
  5. Onopriyenko A.V., Kostenikov N.A., Velichko O.B., Bazaleva V.B., Yefimova I.Yu., Usov V.Yu. Using Combined Images Based on Contrast-Enhanced MRI and SPECT with 99mTc-Technetrile in the Diagnosis of Malignant Recurrent Gliomas. Meditsinskaya Vizualizatsiya = Medical Visualization. 2004;5:38-46 (In Russ). EDN XAFFZV.
  6. Usov V.Yu., Babikov V.Yu., Minin S.M., Sukhov V.Yu., Kostenikov N.A., Luchich M.A. Quantitative SPECT of the Brain with 99mTc-Technetrile in Diagnostics, Evaluation of the Effectiveness of Complex Therapy of Low-Grade Gliomas and Prognosis of Patients’ Life. Rossiyskiy Neyrokhirurgicheskiy Zhurnal im. Professora A.L. Polenova = Russian Neurosurgical Journal named after Professor A.L. Polenov. 2023;15;S1:26-27 (In Russ.). EDN QGPXKZ.
  7. Belitskaya Ye.D., Dimitreva V.A., Kozlov A.N., Oleynikov V.A., Zalygin A.V. Radiopharmaceuticals for the Diagnosis of Malignant Neoplasms Non-Specific to Glucose. Bioorganicheskaya Khimiya = Bioorganic Chemistry. 2023;49;6:575-590. (In Russ.). Doi: 10.31857/S0132342323060039.
  8. Chernov V.I., Dudnikova Ye.A., Zel’chan R.V., Bragina O.D., Medvedeva A.A., Tolmachev V.M. 99mTc-1-thio-D-glucose in Patients with Lymphomas: Safety of Use, Pharmacokinetics and Dosimetric Characteristics. Onkologicheskiy Zhurnal: Luchevaya Diagnostika, Luchevaya Terapiya = Journal of Oncology: Diagnostic Radiology and Radiotherapy. 2022;5;4:18-30 (In Russ.). Doi: 10.37174/2587 7593 2022 5 4 18-30.
  9. Zhang Junbo, Ren Jialei, Lin Xiao, Wang Xuebin. Synthesis and Biological Evaluation of a Novel 99mTc Nitrido-Radiopharmaceutical with Deoxyglucose Dithiocarbamate, Showing Tumor Uptake. Bioorganic & Medicinal Chemistry Letters. 2009;19;10:2752-2754.
  10. Usov V.Yu., Belyanin M.L., Churin A.A., Borodin O.Yu., Lishmanov Yu.B., Shimanovskiy N.L. Trans-1,2-Diaminocyclohexane-n,n,n’,n’-Tetraacetic Acid (DCTA) as a Universal Chelator for MR Imaging and Single-Photon Emission Imaging Using Complexes with Mn (Cyclomang) and 99mTc (Cyclotech). Diagnosticheskaya i Interventsionnaya Radiologiya = Diagnostic and Interventional Radiology. 2020;14;3:91-100 (In Russ.). Doi: 10.25512/DIR.2020.14.3.10. EDN KZEKMN.
  11. Shafiq Y.F., Al-Janabi M.A. Preparation, Quality Control and Application of 99mTc-Gluco-Ene-Diolate for Renal Scanning. Nuklearmedizin. 1985;24;2:93-95.
  12. Tarasov N.F., Korsunskiy V.N., Kozlova M.D., Kodina G.Ye. Prospects for the Development and Organization of Serial Production of New Radiopharmaceuticals in the USSR. Meditsinskaya Radiologiya = Medical Radiology. 1990;35;8:35-39 (In Russ.).
  13. Kodina G.Ye., Korsunskiy V.N. Status and Process of Using Technetium-99m Radiopharmaceuticals in Russia. Radiokhimiya = Radiochemistry. 1997;38;5:385-392 (In Russ.).
  14. Vistler R.L., Vol’from M.L. Metody Khimii Uglevodov = Methods of Carbohydrate Chemistry. Ed. N.K. Kochetkov. Moscow, Mir Publ., 1967. p. 221. (In Russ.).
  15. Zhdanov Yu.A., Dorofeyenko G.N., Korol’chenko G.A., Bogdanova G.V. Praktikum po Khimii Uglevodov = Practical Training in Carbohydrate Chemistry. Moscow, Rosvuzizdat Publ., 1963. 276 p. (In Russ.).
  16. Korenman I.M. Fotometricheskiy Analiz. Metody Opredeleniya Organicheskikh Soyedineniy = Methods for Determining Organic Compounds. Moscow, Khimiya Publ., 1975. 370 p. (In Russ.).
  17. Grebennikova O.V., Sul’man A.M. Biocatalytic Synthesis of D-Gluconic Acid. Vestnik Tverskogo Gosudarstvennogo Universiteta. Seriya: Khimiya = Bulletin of Tver State University. Series: Chemistry. 2021;1;43:30-35 (In Russ.).
  18. Koblyakov V.A. Hypoxia and Glycolysis as Factors Determining the Malignant Phenotype. Tsitologiya = Cytology. 2016;58;7:499-506 (In Russ.). EDN WIDSKX.
  19. Kalinina Ye.V., Gavrilyuk L.F. Glutathione Synthesis in Tumor Cells. Biokhimiya = Biochemistry. 2020;85;8:1050-1065 (In Russ.).
  20. Kweon Y., Park J.Y., Kim Y.J., Lee Y.S., Jeong J.M. Imaging Hydrogen Sulfide in Hypoxic Tissue with 99mTc-Gluconate // Molecules. 2020. V.26. No.1. P. 96. Doi: 10.3390/molecules26010096.
  21. Labushkina A.A., Klement’yeva O.Ye., Kodina G.Ye., Samoylov A.S. Development of Methodological Documents Regulating Clinical Trials of New Radiopharmaceutical Drugs. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2023;68;3:71–77 (In Russ.). Doi: 10.33266/1024-6177-2023-68-3-71-77.
  22. Zimmer A.M., Pavel D.G. Rapid Miniaturized Chromatographic Quality Control Procedures for Tc-99m Radlopharmaceuticais. J. Nucl. Med. 1977;18:1230-1233.
  23. Usov V.Yu., Minin S.M., Kobelev Ye., Anashbayev Zh.Zh., Tarabanovskaya N.A., Denisova N.V. MR Tomographic Evaluation of the Effectiveness of Neoadjuvant Chemotherapy for Breast Cancer Based on Computational Pharmacokinetic Analysis of Tumor Paramagnetic Uptake with Intravenous Contrast Enhancement. Translyatsionnaya Meditsina = Translational Medicine. 2024;11;5:428-444 (In Russ.). Doi: 10.18705/2311-4495-2024-11-5-428-444. EDN: ERFXXC
  24. Narkevich B.Ya. Circulation Models for Functional Radionuclide Diagnosis with Organotropic Tadiopharamaceuticals. Мedical Radiology and Radiation Safety. 1997;42;3:18-22.
  25. Khabriyev R.U. Rukovodstvo po Eksperimental’nomu (Doklinicheskomu) Izucheniyu Novykh Farmakologicheskikh Veshchestv = Guide to Experimental (Preclinical) Study of New Pharmacological Substances. Moscow, Meditsina Publ., 2012. 832 p. (In Russ.). ISBN 5-225-04219-8. EDN QCIIOB.
  26. Panov V.O., Shimanovskiy N.L. Does the Stability of Gadolinium-Containing Magnetic Resonance Contrast Agents Have Clinical Significance? Vestnik Rentgenologii i Radiologii = Journal of Radiology and Nuclear Medicine. 2016;9;4:243-256 (In Russ). EDN WKNXDN.
  27. Kweon Y., Park J.Y., Kim Y.J., Lee Y.S., Jeong J.M. Imaging Hydrogen Sulfide in Hypoxic Tissue with [99mTc]Tc-Gluconate. Molecules. 2020;26;1:96. Doi: 10.3390/molecules26010096.
  28. Park J.Y., Kim Y.J., Lee J.Y., Lee Y.S., Jeong J.M. Imaging of the Third Gasotransmitter Hydrogen Sulfide Using 99mTc-Labeled Alpha-Hydroxy Acids // Nucl Med Biol. 2019;76-77:28-35. Doi: 10.1016/j.nucmedbio.2019.09.003.

 

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. This work has been carried out without additional funding support, within the framework of the Cooperation Agreement between the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, and the Sino‒Russian Park of Science and Technologies, Changchun, China.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.01.2026. Accepted for publication: 25.02.2026.

 

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