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Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 43–47
S.S. Aleksanin, S.V. Serebryakova, I.M. Levashkina
Neocortex (Frontal and Temporal Lobe) Discirculatory Lesions of the Chernobyl Accident Liquidators at the Remote Period (Based on Diffusion Tensor MRI Data)
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia, S-Petersburg, Russia
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Abstract
Purpose: To find the distinctive features of the white matter tracts’ structural changes for Chernobyl accident liquidators with ebcephalopathy at the remote period using DT-MRI methods.
Material and methods: Chernobyl accident liquidators group (41 subjects) and group of control (49 subjects), all subjects with stage II of encephalopathy, mean age of liquidators’ group 68.3 ± 6.9 years, gropup of control — 68.6 ± 5.8 years. All subjects were clinically examined to confirm encephalopathy stage, hypertension, diabetes (and prove patients of both groups have comparable level of damage of those deseases), as well as with routine MRI and DT-MRI protocols. According routine MRI results, all subjects of both groups had high level of discirculatory damages: multifocal lesions of white matter and periventricular leukoaraiosis, mixed replacement hydrocephalus.
Results: Liquidator’s group average fraction anisotropy coefficient (CFA) had shown statistically significant reduction in four frontal and temporal lobe tracts of neocortex if compare with average CFA in the group of control: superior longitudinal fasciculi (р < 0.02); front sections of corona radiata (р < 0.02); anterior horn of internal capsule (р < 0.01), inferior longitudinal fasciculi (р < 0.01).
Conclusion: Frontal and temporal lobe tracts of neocortex, responsible for cognitive processes, are the most sensible to accident liquidation negative factors. Cerebral structure changes, found for group of liquidators, are similar to elder people with encephalopathy, but are clnically more strongly marked, what proves hyoptesis of early aging of liquidators’ brain structures.
Key words: nuclear accidents, Chernobyl Nuclear Power Plant, Chernobyl accident liquidator, diffusion-tensor MRI (DT‑MRI), fraction anysotropy (FA), cognitive disorders, discirculatory encephalopathy
For citation: Aleksanin SS, Serebryakova SV, Levashkina IM. Neocortex (Frontal and Temporal Lobe) Discirculatory Lesions of the Chernobyl Accident Liquidators at the Remote Period (Based on Diffusion Tensor MRI Data). Medical Radiology and Radiation Safety. 2020;65(4):43-7 (In Russ.).
DOI: 10.12737/1024-6177-2020-65-4-43-47
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Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Conflict of interest. The authors declare no conflict of interest.
Финансирование. Исследование не имело спонсорской поддержки.
Financing. The study had no sponsorship.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Contribution. Article was prepared with equal participation of the authors.
Поступила: 15.08.2020. Принята к публикации: 01.09.2020.
Article received: 15.08.2020. Accepted for publication: 01.09.2020.