JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

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Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 4. P. 48–57

T.V. Azizova1, N. Hamada2, E.S. Grigoryeva1, E.V. Bragin1

Risk of Various Types of Cataracts in a Cohort of Mayak Workers Following Chronic Occupational Exposure to Ionizing Radiation

1 Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia
2 Radiation Safety Research Center, Nuclear Technology Research Laboratory,
Central Research Institute of Electric Power Industry, Tokyo, Japan
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To assess cataract type specific risks in a cohort of workers occupationally exposed to ionizing radiation over prolonged periods.

Material and methods: The present retrospective cohort study included 22,377 workers first employed at a nuclear production facility in 1948–1982 and followed up till the end of 2008. By the end of the follow-up period in the study worker cohort 3123 cases of cortical cataract, 1239 cases of posterior subcapsular cataract (PSC) and 2033 cases of nuclear cataracts were registered over 486,245, 489,162, 492,004 person-years of follow-up, respectively.

Results: The incidence of PSC, cortical and nuclear cataracts was significantly linearly associated with the cumulative radiation dose. The excess relative risk per unit dose of external gamma-ray exposure (ERR/Sv) was 0.91 (95 % CI: 0.67–1.20) for PSC, 0.63 (95 % CI: 0.49–0.76) for cortical cataracts and 0.47 (95 % CI: 0.35–0.60) for nuclear cataracts. Exclusion of an adjustment for neutron dose and inclusion of additional adjustments for body mass index and smoking index reduced ERRs/Sv for all types of cataracts. However, an additional adjustment for glaucoma increased the incidence risks of cortical and nuclear cataracts just modestly (but not for PSC). Inclusion of an adjustment for diabetes mellitus reduced the ERR/Sv of external gamma-ray exposure only for PSC incidence. Increased incidence risks of all cataract types were observed in both males and females of the study cohort, but ERR/Sv was significantly higher in females (p < 0.001), especially for PSC.

Conclusion: The incidence of various types of cataracts in the cohort of workers occupationally chronically exposed to ionizing radiation was associated with the cumulative dose of external gamma-ray exposure.

Key words: ionizing radiation, chronic exposure, Mayak PA workers, posterior subcapsular cataract, cortical cataract, nuclear cataract, sex differences

For citation: Azizova TV, Hamada N, Grigoryeva ES, Bragin EV. Risk of Various Types of Cataracts in a Cohort of Mayak Workers Following Chronic Occupational Exposure to Ionizing Radiation. Medical Radiology and Radiation Safety. 2020;65(4):48-57 (In Russ.).

DOI: 10.12737/1024-6177-2020-65-4-48-57

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Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Conflict of interest. The authors declare no conflict of interest.
Финансирование. Исследование не имело спонсорской поддержки.
Financing. The study had no sponsorship.
Участие авторов. Cтатья подготовлена с равным участием авторов.
Contribution. Article was prepared with equal participation of the authors.
Поступила: 29.07.2020. Принята к публикации: 10.09.2020.
Article received: 29.07.2020. Accepted for publication: 10.09.2020.

Information about the autors

Azizova T.V. http://orcid.org/0000-0001-6954-2674
Grigoryeva E.S. http://orcid.org/0000-0003-1806-9922
Bragin E.V. http://orcid.org/0000-0003-0410-5048


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