JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2021. Vol. 66. № 3. P. 48–54
I.L. Bukhovets1, O.Ya. Vasiltseva1,2, Yu.B. Lishmanov1,2, I.N. Vorozhtsova1,3, A.G. Lavrov3,
E.A. Ivanovskaya5, A.M. Cherniavskii2, W.Yu. Ussov1,2
Design and Clinical Evaluation of Pharmacologic Stress-Test with Dalargin
for SPECT Detection of Viable Myocardium in Patients after Myocardial Infarction
1 Cardiology Research Institute, Tomsk National Medical Research Center, Tomsk, Russia
2 E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia
3 National Research Tomsk Polytechnic University, Tomsk, Russia
4 Siberian State Medical University, Tomsk, Russia
5 Novosibirsk State Medical University, Novosibirsk, Russia
Contact person: Wladimir Yurievich Ussov: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To develop a functional stress-test with Dalargin used as a pharmacological stress agent and to study its diagnostic capabilities for quantifying the general and segmental systolic function of the left ventricle in patients with IHD using SPECT and echo methods.
Material and methods: The study comprised 29 male patients with CHD-angina of 2-3 functional classes, studied on 15–25 days (on average 20 ± 2.8 days) after a large-focal myocardial infarction. A fractional step-wise injection of Dalargin was performed with step doses as 0.1 mg / kg (1 ml up to a total of 8 ml, with intervals of 90 seconds, for a total of 12 minutes), in a supine position. After each dose of Dalargin, blood pressure, heart rate, ECG were recorded, and an echocardiographic assessment of hemodynamic parameters and local contractility was carried out. At the peak of the effect of dalargin, 99mTc-Tetrofosmin was administered intravenously (370 – 540 MBq), followed by chest SPECT.
Results: The optimal dose of dalargin for assessing the contractility of the LV was 0.3 mg/kg. From the data of myocardial perfusion SPECT, at dalargin test, the number of segments with normal regional blood supply increased statistically significantly from 56,0 % to 64,7 %, the number of hypoperfused segments decreased from 41.0% to 33.7% as compared to rest, and the number of non-perfused ones – from 3.0 % to 1.6 %. Spearman’s correlation coefficient between segmental contractility and local perfusion at the top dalargin inotropic effect was high and significant (R=0.67, p<0.01). The sensitivity and specificity of the pharmacological test with intravenous administration of dalargin for prediction of postoperative improvement of perfusion and contractility of the viable myocardium were: sensitivity 78.8 %, specificity 76.4 %, diagnostic accuracy 77.6 %.
Conclusion. The use of the agonist of the μ - and δ-opioid receptors dalargin as a pharmacological stress-agent at perfusion SPECT and Stress Echocardiography to assess the contractile reserve of a dysfunctional viable myocardium is informative and appropriate. In patients with IHD who have suffered a myocardial infarction and are referred to myocardial revascularization, dalargin can be employed as an effective stress-agent for assessing the reserve of perfusion and contractility of dysfunctional left ventricular myocardium using perfusion SPECT and echocardiography.
Key words: SPECT, myocardial blood flow, functional reserve, dalargin, dalargin functional test, heart ultrasound
For citation: Bukhovets IL, Vasiltseva OYa, Lishmanov YuB, Vorozhtsova IN, Lavrov AG, Ivanovskaya EA, Cherniavskii AM, Ussov WYu. Design and Clinical Evaluation of Pharmacologic Stress-Test with Dalargin for SPECT Detection of Viable Myocardium in Patients after Myocardial Infarction. Medical Radiology and Radiation Safety. 2021;66(3):48-54.
DOI: 10.12737/1024-6177-2021-66-3-48-54
References
- Maslov LN, Lishmanov YuB, Maryzhnaya NV. Opioidergic Component of Morpho-functional Changes in Myocardium in Stress and Adaptation. Tomsk, STT Publ., 2003. 237 p. (In Russian).
- Ussov WYu, Efimova IYu, Plotnikov MP, Karpov RS. Patterns of Cerebral Blood Flow Reactivity in Adenosine Stress-test in Patients with Carotid Stenosis, Evaluated with MRI and 99mTc-HMPAO SPECT Brain study. Vestnik Rentgenologii i Radiologii = Russ. J. Radiol. 2000;6:4-9 (In Russian).
- Aronov DM, Lupanov VP. Functional Tests in Cardiology. Moscow, Medpress-Inform, Publ., 2007 (In Russian).
- Borisenko VG, Gubareva EA, Kade AH. Myocardial Reactions to Ischemia. Therapeutic Archive. 2010;82;3:64-67 (In Russian).
- Bydanova SS, Kiryanova AN, Leshchinskii LA, Bydanov SA. Clinical Efficiency of Application of an Analogue of Endogenous Neuropeptides Dalargin in Complex Therapy of Acute Coronary Syndrome. Practical Medicine. 2004;1;6:22-23 (In Russian).
- Griffin B, Topol E. Cardiology. Moscow, Praktika, Publ., 2008 (In Russian).
- 7. Maslov LN, Naryzhnaya NV. Receptor Mechanisms and Signaling of Myocardial Protection Against Ischemic – Reperfusion Damage. Tomsk, University of Control Systems and Radioelectronics Publ., 2018. 352 p. (In Russian).
- Ansheles AA, Sergienko IB, Denisenko-Kankiya EI, Sergienko VB. Myocardial Perfusion SPECT and Coronary Angiography Results in Patients with Different Pre-Test Probability of Ishemic Heart Disease. Therapeutic Archive. 2020;92;4:30-36 (In Russian). DOI:10.26442/00403660.2020.04.000549.
- Migrino RQ, Xiaoguang Zhu, Pajewski N. Assessment of Segmental Myocardial Viability Using Regional 2-dimensional Strain Echocardiography. Journal of the American Society of Echocardiography. 2007;20;4:342-351. DOI:10.1016/j.echo. 2006.09.011.
- Dontsov AV. Possibilities of Dalargin in Treatmen of Patients Ischemic Heart Disease. Digest of New Medical Technologies. 2012;19;3:159-161 (In Russian).
- Lishmanov YuB, Makarova EV, Chernov VI, Vesnina JV, Babokin VE, Vorozhtsova IN, Bukhovets IL. I99Tl Reinjection Combined with SPECT Imaging in Myocardium Hibernation Diagnosis. Medical Radiology and Radiation Safety. 2005;50;1:62-67 (In Russian).
- Saidova MA. Current Methods of Detection of Viable Myocardium. Kardiologia. 2005;9: 47-54 (In Russian).
- Rosa S, Lauro C. The Clinical use of Stress Echocardiography in Ischemic Heart Disease. Cardiovascular Ultrasound. 2017;15:7. DOI 10.1186/s12947-017-0099-2.
- Vorozhtsova IN, Bukhovets IL, Bezlyak VV, Babokin VE, Lishmanov YuB. Prognostication of Hemodynamic Efficacy of Surgical Correction of Chronic Coronary Insufficiency Based on Stress test with Nitroglycerine. Cardiologia. 2003;6:23-27 (In Russian).
- Lishmanov YuB, Maslov LN. Ishemic Post-Conditioning of the Heart. Receptor Mechanisms and Possibilities of Clinical Applications. Cardiologia. 2010;6:68-74 (In Russian).
- Rybakova MK, Alekhin MN, Mit’kov VV. Echocardiohgraphy: Practical Guidebook in Ultrasound Diagnosis. Moscow, Vidar-M Publ., 2008. 544 p. (In Russian).
- Ross J. Myocardial Perfusion-Contraction Matching. Implications for Coronary Heart Disease and Hibernation. Circulation. 1991;83:1076-1083.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Development of the concept and design of the study: Usov V.Yu., Bukhovets I.L., Vasiltseva O.Ya., Chernyavsky A.M., Lishmanov Yu.B.; Obtaining, analysis and scientific interpretation of data: Vasiltseva O.Ya., Bukhovets I.L., Lavrov A.G., Vorozhtsova I.N., Ivanovskaya E.A., Lishmanov Yu.B., Usov V.Yu.; Substantiation of the manuscript and verification critical intellectual content: Bukhovets I.L., Lavrov A.G., Vorozhtsova I.N., Chernyavsky A.M., Usov V.Yu.; Final approval of the manuscript for publication: Bukhovets I.L., Vasiltseva O.Ya., Lishmanov Yu.B., Chernyavsky A.M., Usov V.Yu.
Article received: 18.08.2020.
Accepted for publication: 19.01.2021