JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 70–76
Justification and Application of Sufficiency Criterion
for Measuring the Activity of Uranium Radioisotopes in Biological Samples
E.A. Dashanova1,2, A.A. Molokanov1, E.A. Korneva1
1A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
2National Research Nuclear University MEPhI (Moscow Engineering Physics Institute). Moscow, Russia
Contact person: Ekaterina Alexandrovna Dashanova: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Ensuring the fulfillment of the sufficiency n criterion when measuring the activity of uranium radionuclides in biological samples carried out within the individual monitoring programme by calculation of the uncertainty and characteristics limits for measurements.
Material and methods: The sufficiency criterion definition is given, which determines the maximum value of the decision threshold for measurements carried out for the individual monitoring of workers at which the fact of non-exceeding of the annual dose limit or permissible level takes place, taking into account the uncertainty of the dose assessment. A model approach is used to calculate the sufficiency criterion and characteristics limits when measuring the radioactive material excrected by individual workers. The model approach consisted in the development of a calculation model based on the functional dependence of measured input values on the process of radiochemical preparation and subsequent spectrometric measurement of the sample.
Results: A model has been developed for calculating the activity of uranium radionuclides 234U, 235U and 238U in a biological sample based on the description of the procedure for spectrometric measurement, which consisted in the deposition by the electrolytic method on the target after chromatographic extraction of uranium from the urine sample. The reference radioactive solution of the 232U radionuclide added to the sample as a reference point for determining the efficiency of uranium radionuclide separation (chemical yield). Equations are obtained for calculating the values of the decision threshold and the detection limit for the total activity of the above alpha-emitting uranium radionuclides. Using these equations, the dependence of the decision threshold and the detection limit on measurement time is determined for the given input data. This allows planning the measurement time at which the activity of uranium radionuclides in the sample can be determined reliably or at which the sufficiency criterion of the measurement method will be provided (necessary in the case when the activity is not detected, that is, the measurement result is less than the decision threshold). The values of the activity of uranium radionuclides 234U, 235U and 238U and the corresponding characteristics limits for the measurement were calculated on the basis of a real example of spectrometric measurement of the activity of uranium radionuclides in a sample.
Conclusion: Ensuring the fulfillment of the sufficiency criterion when measuring the activity of uranium radionuclides in biological samples is achieved by the correct determination of the sample measurement time. This is determined by time dependence analysis of the characteristics limits (the decision threshold and the detection limit ) for the measurement of the total activity of the above alpha-emitting uranium radionuclides 234U, 235U and 238U.
Key words: individual monitoring programme, alpha spectrometry, sufficiency criterion, decision threshold, detection limit, confidence interval
For citation: Dashanova EA, Molokanov AA, Korneva EA. Justification and Application of Sufficiency Criterion for Measuring the Activity of Uranium Radioisotopes in Biological Samples. Medical Radiology and Radiation Safety. 2021;66(4):70-76.
DOI: 10.12737/1024-6177-2021-66-4-70-76
References
1. Radiation Safety Standards NRB-99/2009. Hygienic Standards SP 2.6.1.2523- 09. Moscow. 2009. 100 p. (In Russian).
2. MU 2.6.1.065-14. Dosimetric Control of Occupational Internal Exposure. General Requirements (In Russian).
3. Molokanov AA, Kukhta BA. Development of the Internal Dose Assessment System for the Monitoring of Workers – Use of Modern Technologies. ANRI. 2019; (4) : 38-50. (In Russian).
4. ISO 11929:2010(E). Determination of the Characteristic Limits (Decision Threshold, Detection Limit and Limits of the Confidence Interval) for Measurements of Ionizing Radiation – Fundamentals and Application. Geneva. 2010.
5. ISO/IEC Guide 98-3:2008(E). Guide to the Expression of Uncertainty in Measurements (GUM:1995). Uncertainty of measurement. Geneva. Switzerland. 2008.
6. State Standard 34100.3-2017/ ISO/IEC Guide 98-3:2008. Uncertainty of Measurement. Part 3. Guide to the Expression of Uncertainty in Measurements. Moscow, Publ, Standardinform. 2018. (In Russian).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 16.02.2021.
Accepted for publication: 20.04.2021.