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Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 1. P. 56-64

DOI: 10.12737/25062

Nuclear Medicine in Diagnosis of Angiopathy in Patients with Diabetes Mellitus Type 2

D.S. Kharina1,2, T.A. Poletaeva1, A.K. Kondakov1,2, D. Yu. Mosin1, A.E. Nikitin1, I.A. Znamensky1,2

1. Central Clinical Hospital of RAS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. N.I. Pirogov Russian National Research Medical University, Moscow, Russia

D.S. Kharina – radiologist in nuclear medicine department of Central Clinical Hospital of the RAS, post-graduate student in radiology and radiotherapy department, Pirogov Russian National Research Medical University (RNRMU); T.A. Poletaeva – head of therapeutic department of Central Clinical Hospital of the RAS; A.K. Kondakov – radiologist in nuclear medicine department of Central Clinical Hospital of the RAS, post-graduate student of radiology and radiotherapy department, Pirogov RNRMU; D.Yu. Mosin – radiologist in nuclear medicine department of Central Clinical Hospital of the RAS; A.E. Nikitin – head of Central Clinical Hospital of the RAS, MD., professor; I.A. Znamensky – head of nuclear medicine department of Central Clinical Hospital of the RAS, MD, professor of radiology and radiotherapy department, Pirogov RNRMU

Abstract

Purpose: To determine the role of nuclear medicine techniques in the early detection of angiopathy in patients with diabetes and to estimate their accuracy in comparison with routine diagnostic methods for evaluation of target organ damage.

Material and methods: A literature review, selected from the Russian and international bibliographic databases (RSCI, Medline, Google Scholar), dedicated to diagnostic technologies for identification of angiopathy in patients with diabetes mellitus.

Results: 193 sources dedicated to the diagnosis of micro- and macrovascular damage were analyzed, 66 of which were included in this study, 54 of them international and 12 domestic ones responding to the purpose of the study. The analysis revealed that the radionuclide methods of investigation reflecting the functional state of the tissues were evaluated in a small number of publications on early diagnosis angiopathy caused by diabetes mellitus type 2. Most often, high blood glucose concentration damages kidney tissue and myocardium. It is shown that the methods of dynamic nephroscintigraphy and ECG-gated myocardial perfusion SPECT allow to evaluate the progression of micro- and macrovascular disease before the manifestation of paraclinical signs according to other diagnostic methods. Key determined parameter in dynamic nephroscintigraphy is glomerular filtration rate, which declines on the early stages of the disease. Myocardial perfusion SPECT imaging provides a possibility to assess frequency and severity of ischemic myocardial injury.

Conclusions: The use of nuclear medicine techniques in the diagnosis of angiopathy in diabetes allows verification of early damage to target organs. The most effective diagnostic methods for this purpose are dynamic nephroscintigraphy and myocardial perfusion SPECT which sensitivity is substantially higher than conventional diagnostic methods.

Key words: diabetes mellitus type 2, nuclear medicine, dynamic nephroscintigraphy, myocardial perfusion imaging, impaired glucose tolerance

REFERENCES

  1. Ametov A.S., Kurochkin I.O., Zubkov A.A. Saharnyj diabet i serdechno-sosudistye zabolevaniya. Russkij med. zhurnal. 2014. Vol. 13. P. 954–961. (In Russ.).
  2. Roglic G., Unwin N., Bennet P. et al. The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care. 2005. Vol. 28. No. 9. P. 2130–2135.
  3. Halter J.B., Musi N., McFarland Horne F. et al. Diabetes and cardiovascular disease in older adults: current status and future directions. Diabetes. 2014. Vol. 63. No. 8. P. 2578–2589.
  4. Chowdhury R., Narayan K. M., Zabetian A. et al.Genetic studies of type 2 diabetes in South Asians: a systematic overview. Curr. Diabetes Rev. 2014. Vol. 10. No. 4. P. 258–274.
  5. Neumann A., Schoffer O., Norstrom F. et al. Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Vasterbotten Sweden. Heal. Qual. Life Outcomes. 2014. Vol. 12. No. 1. P. 150–156.
  6. Murtagh G., O Connell J., O Connell E. et al. IImportance of risk factor management in diabetic patients & reduction in stage B heart failure. QJM. 2015. 108. No. 4. P. 307–314.
  7. Dedov I.I., Balabolkin M.I., Marova E.I. Bolezni organov ehndokrinnoj sistemy. Moscow: Medicina. 568 p. (In Russ.).
  8. Balabolkin M.I., Klebanova E.M., Kreminskaya V.M. Sovremennye voprosy klassifikacii, diagnostiki i kriterii kompensacii saharnogo diabeta. Saharn. diabet. Vol. 10. P. 5–12. (In Russ.).
  9. Cugnet C., Thivolet C. Classification of diabetes in young adults: new concepts for an old disease. Diabetes Metab. 2005. Vol. 31. No. 6. P. 595Kim598.
  10. Cusnir V., Cusnir V. Jr., Bendelic E. Diabetic retinopathy, practical value of classification. Oftalmologia. 2010. Vol. 54. No. 3. P. 61-65.
  11. Kawasaki S., Misawa H., Tamura Y. et al. Relationship between coronary artery disease and retinopathy in patients with type 2 diabetes mellitus. Intern. Med. 2013. Vol. 52. No. 22. P. 2483-2487.
  12. Chantelau E.A., Grutzner G. Is the Eichenholtz classification still valid for the diabetic Charcot foot? Journal Article. Swiss Med. Wkly. 2014. Vol. 144. P. w13948.
  13. Edo A.E., Okaka E., Ezeani I.U. Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. Niger J. Clin. Pr. 2014. Vol. 17. No. 5. P. 658-661.
  14. Vahora R., Thakkar S., Marfatia Y. Skin, a mirror reflecting diabetes mellitus: A longitudinal study in a tertiary care hospital in Gujarat. Indian J. Endocrinol. Metab. 2013. Vol. 17. No. 4. P. 659-664.
  15. Hellgren K.J., Agardh E., Bengtsson B. Progression of early retinal dysfunction in diabetes over time: results of a long-term prospective clinical study. Diabetes. 2014. Vol. 63. No. 9. P. 3104-3111.
  16. Liu M., Li X.C., Lu L. et al. Cardiovascular disease and its relationship with chronic kidney disease. Eur. Rev. Med. Pharmacol. Sci. 2014. Vol. 18. No. 19. P. 2918-2926.
  17. Aggarwal A., Aggarwal S., Sharma V. Cardiovascular risk factors in young patients of coronary artery disease: differences over a decade. J. Cardiovasc. Thorac. Res. 2014. Vol. 6. No. 3. P. 169-173.
  18. Kakrani A.L., Gokhale V.S., Vohra K.V. et al. Clinical and nerve conduction study correlation in patients of diabetic neuropathy // J. Assoc. Physicians India. 2014. Vol. 62. № 1. P. 24-27.
  19. Vukojevic Z., Pekmezovic T., Nikolic A. et al. Correlation of clinical and neurophysiological findings with health-related quality of life in patients with diabetic polyneuropathy. Vojn. Pregl. 2014. Vol. 71. No. 9. P. 833-838.
  20. Saraswathy R., Anand S., Kunnumpurath S.K. et al. Chromosomal aberrations and exon 1 mutation in the AKR1B1 Gene in patients with diabetic neuropathy. Ochsner J. 2014. 14. No. 3. P. 339-342.
  21. Balabolkin M.I. Saharniy diabet. Moscow: Medicina. 384 p. (In Russ.).
  22. van Eeckhoudt S., Minet M., Lecouvet F. et al. Charcot spinal arthropathy in a diabetic patient. Acta Clin. Belg. 2014. Vol. 69. No. 4. P. 296-298.
  23. Lu Q., Ma Y., Xu Y.S. et al. Apelin in epiretinal membranes of patients with proliferative diabetic retinopathy. Mol. Vis. 2014. Vol. 20. P. 1122-1131.
  24. Lim Ak. Diabetic nephropathy - complications and treatment. Int. J. Nephrol. Dis. 2014. Vol. 7. P. 361-381.
  25. Efimov A.S. Diabeticheskie angiopatii. Moscow: Medicina. 288 p. (In Russ.).
  26. Stacenko M.E., Derevyanchenko M.V. Korrekciya disfunkcii ehndoteliya u bol’nyh arterial’noj gipertenziej s saharnym diabetom 2-go tipa na fone kombinirovannoj antigipertenzivnoj terapii. Terap. arhiv. 2014. Vol. 86. No. 8. P. 90-93. (In Russ.).
  27. Tadzhieva D.CH., Tron’ko M.D., Slavnov V.M. et al. Dinamicheskaya renoscintigrafiya i radionuklidnaya angiografiya v diagnostike doklinicheskih form diabeticheskoj nefropatii. Ukr. radiol. zhurnal. 1999. Vol. 7. No. 3. P. 254-258. (In Russ.).
  28. Mogensen C.E., Christensen C.K., Vittinghus E. The stages in diabetic renal disease with emphasis on the stage of incipient diabetic nephropathy. Diabetes. 1983. Vol. 32. Suppl 2. P. 64-78.
  29. Damsgaard E.M., Mogensen C.E. Microalbuminuria in elderly hyperglycaemic patients and controls. Diabet. Med. 1986. Vol. 3. No. 5. P. 430-435.
  30. Chen X., Xiao W., Li X. et al. In vivo evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria. Front Med. 2014. Vol. 5. P. 73-78.
  31. Kim M.K, Yun K.J., Chun H.J. et al.Clinical utility of serum beta-2-microglobulin as a predictor of diabetic complications in patients with type 2 diabetes without renal impairment. Diabetes Metab. 2014. Vol. 40. No. 6. P. 459-465. DOI: 10.1016/j.diabet.2014.08.002.
  32. Toste S., Viamonte S., Barreira A. et al. Cardiac rehabilitation in patients with type 2 diabetes mellitus and coronary disease: A comparative study // Rev. Port. Cardiol. 2014. Vol. 33. P. 313-315.
  33. Chiang H.H., Tseng F.Y., Wang C.Y. et al. All-cause mortality in patients with type 2 diabetes in association with achieved hemoglobin a1c, systolic blood pressure, and low-density lipoprotein cholesterol levels. PLoS One. 2014. Vol. 9. No. 10. P. e109501.
  34. Yu L.B., Shen Y., Li L.X. et al. Detection rates of atherosclerosis by carotid versus lower limb ultrasonography in newly diagnosed type 2 diabetics. Zhonghua Yi Xue Za Zhi. 2013. Vol. 93. No. 27. P. 2143-2145.
  35. Bornfeldt K.E. 2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis. Arter. Thromb Vasc. Biol. 2014. Vol. 34. No. 4. P. 705-714.
  36. Hayashi T., Kotani H., Yamaguchi T. et al.Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes. Proc. Natl. Acad. Sci. USA. 2014. Vol. 111. No. 3. P. 1168-1173.
  37. Ametov A.S. SDVT. Problemy i resheniya. Ucheb.pos. 2-e izd. Moscow: GEHOTAR-Media, 2014. 1032 p. (In Russ.).
  38. Anciferov M.B., Galstyan G.R., Milen’kaya T.M. Oslozhneniya saharnogo diabeta. In Dedov I.I. (ed.). Moscow: Endokrinologicheskij nauchnyj centr RAMN, 1995. 21 p. (In Russ.).
  39. Orasanu G., Plutzky J. The pathologic continuum of diabetic vascular disease. J. Amer. Coll. Cardiol. 2009. Vol. 53. No. 5 Suppl. P. S35-42.
  40. Franch-Nadal J., Mata-Cases M., Vinagre I. et al. Differences in the cardiometabolic control in type 2 diabetes according to gender and the presence of cardiovascular disease: results from the eControl study. Int. J. Endocrinol. 2014. Vol. 2014. Articale ID 131709, 11 p. DOI: 10.1155/2014/131709.
  41. Bergis D., Bergis P.M., Hermanns N. et al. Coronary artery disease as an independent predictor of survival in patients with type 2 diabetes and Charcot neuro-osteoarthropathy. Acta Diabetol. 2014. Vol. 51. No. 6. P. 1041-1048.
  42. Cox A.J., Hsu F.C., Freedman B.I. et al. Contributors to mortality in high-risk diabetic patients in the diabetes heart study. Diabetes Care. 2014. Vol. 37. No. 10. P. 2798-2803.
  43. Juarez D.T., Demaris K.M., Goo R. et al. Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience. Diabetes Metab. Syndr. Obes. 2014. Vol. 7. P. 487-494.
  44. Ferrannini E. The target of metformin in type 2 diabetes. N. Engl. J. Med. 2014. Vol. 371. No. 16. P. 1547-1548.
  45. Ryden L., Standl E., Bartnik M. et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The task force on diabetes and cardiovascular diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur. Hear. J. 2007. Vol. 28. No. 1. P. 88-136.
  46. Gross J.L., de Azevedo M.J., Silveiro S.P. et al. Diabetic nephropathy: diagnosis, prevention and treatment. Diabetes Care. 2004. Vol. 28. No. 1. P. 42-48.
  47. Fiorini F., Barozzi L. The role of ultrasonography in the study of medical nephropathy. J. Ultrasound. 2007. Vol. 10. No. 4. P. 161-167.
  48. Buturovic-Ponikvar J., Visnar-Perovic A. Ultrasonography in chronic renal failure. Eur. J. Radiol. 2003. Vol. 46. No. 2. P. 115-122.
  49. Colagiuri S., Best J. Lipid-lowering therapy in people with type 2 diabetes. Curr Opin Lipidol. 2002. Vol. 13. No. 6. P. 617-623.
  50. Tatarchenko I.P., Pozdniakova N.V., Dudukina E.A. et al. Clinico­functional evaluation of ischemic episodes and vascular endothelium in patients with type 2 diabetes. Klin. Med. 2006. Vol. 84. No. 12. P. 31-34.
  51. Petrii V.V., Mikova N.V., Makolkin V.I. Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus. Kardiologiia. 2007. Vol. 47. No. 7. P. 22-25.
  52. Young L.H., Wackers F.J., Chyun D.A. et al. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009. Vol. 301. No. 15. P. 1547-1555.
  53. Saito T., Kita M., Taguchi H. et al. Painless myocardial ischemia during the treadmill test in the elderly. Rinsho Byori. 2004. Vol. 52. No. 10. P. 799-803.
  54. Kasim M., Currie G.M., Tjahjono M. et al. Myocardial perfusion SPECT utility in predicting cardiovascular events among indonesian diabetic patients. Open Cardiovasc. Med. J. 2013. Vol. 7. P. 82-89.
  55. Tabit C.E., Chung W.B., Hamburg N.M. et al. Endothelial dys­func­tion in diabetes mellitus: molecular mechanisms and clinical impli­cations. Rev. Endocr. Metab. Disord. 2010. Vol. 11. No. 1. P. 61-74.
  56. Harina D.S., Servuli E.A., Poletaeva T.A. et al. Kompleksnaya radionuklidnaya diagnostika rannih oslozhnenij u pacientov s SDVT. Vestnik RNCRR. 2015. No. 15. P. 56-61. (In Russ.).
  57. Su Y., Liu X.M., Sun Y.M. et al. Endothelial dysfunction in impaired fasting glycemia, impaired glucose tolerance, and type 2 diabetes mellitus. Amer. J. Cardiol. 2008. Vol. 102. No. 4. P. 497-498.
  58. Peix A. Usefulness of nuclear cardiology techniques for silent ischemia detection in diabetics. MEDICC Rev. 2013. Vol. 15. No. 1. P. 33-36.
  59. Bolus N.E. Nuclear medicine instrumentation. J. Nucl. Med. Technol. 2010. Vol. 38. No. 3. P. 172-173.
  60. YUdin A.L., Afanas’eva N.I., Znamenskij I.A. et al. Radionuklidnaya diagnostika. Ucheb. pos. Pod. red. L. YUdina. Moscow: ID «Russkij vrach». 2012. 96 p. (In Russ.).
  61. Slavnov V.N., Savickij S.YU. Radionuklidnye metody v diagnostike oslozhnenij saharnogo diabeta. Arterial’naya gipertenziya. Vol. 2. No. 4. P. 37-42. (In Russ.).
  62. Poirier J.Y., Moisan A., Le Cloirec J. et al. Renal scintigraphy in insulin-dependent diabetes mellitus: early glomerular and urologic dysfunction. J. Diabet. Complications. Vol. 4. No. 3. P. 113-118.
  63. Jun L., Shuhao Z., Rong G. et al. Significance of renal scintigraphy with 99mTc-DTPA for the diagnosis of diabetic nephropathy. Nucl. 1995. Vol. 18. No. 11. P. 679-681.
  64. Strabykina D.S., Poletaeva T.A., Servuli E.A. et al. Rol’ metodov yadernoj mediciny v rannej diagnostike angiopatij pri SDVT. Ross. ehlektron. zh. luchevoj diagnostiki. Prilozhenie. Mat-ly VIII vseross. nac. kongressa luchevyh diagnostov i terapevtov «Radiologiya 2014». 2014. Vol. 3. No. 2. P. 134. (In Russ.).
  65. Schepis T., Benz K., Haldemann A. et al. Prognostic value of stress-gated 99m-technetium SPECT myocardial perfusion imaging: risk stratification of patients with multivessel coronary artery disease and prior coronary revascularization. J. Nucl. Cardiol. 2013. Vol. 20. No. 5. P. 755-762.
  66. Bourque J.M., Beller G.A. Stress Myocardial Perfusion Imaging for Assessing Prognosis: An Update. JACC Cardiovasc. Imag. 2011. Vol. 4. No. 12. P. 1305-13019.
  67. Lugomirski P., Chow B.J., Ruddy T.D. Impact of SPECT myocardial perfusion imaging on cardiac care. Expert Rev. Cardiovasc. Ther. 2014. Vol. 12. No. 11. P. 1247-1249.
  68. Siqueira M.E., Segundo Neto E.M., Kelendjian J.F. et al. Diagnostic value of myocardial radionuclide imaging in patients with multivessel coronary disease. Arq. Bras. Cardiol. 2011. Vol. 97. No. 3. P. 194-198.
  69. Rijnierse M.T., de Haan S., Harms H.J. et al. Impaired hyperemic myocardial blood flow is associated with inducibility of ventricular arrhythmia in ischemic cardiomyopathy. Circ Cardiovasc. Imag. 2014. Vol. 7. No. 1. P. 20-30.
  70. Acampa W., Petretta M., Evangelista L. et al. Myocardial perfusion imaging and risk classification for coronary heart disease in diabetic patients. The IDIS study: a prospective, multicentre trial. Eur. J. Nucl. Med. Mol. Imag. 2012. Vol. 39. No. 3. P. 387-395.
  71. Salehi Y., Fard-Esfahani A., Fallahi B. et al. The myocardial perfusion scintigraphy in asymptomatic diabetic patients. Iran J Nucl Med. 2015. Vol. 23. No. 1. P. 27-35.
  72. Wackers F.J.T., Zaret B.L. Detection of Myocardial Ischemia in Patients With Diabetes Mellitus. Circulation. 2002. Vol. 105. No. 1. P. 5-7.
  73. Giri S., Shaw L.J., Murthy D.R. et al. Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease. Circulation. 2002. Vol. 105. No. 1. P. 32-40.
  74. Padala S.K., Ghatak A., Padala S. et al. Cardiovascular risk stratification in diabetic patients following stress single-photon emission-computed tomography myocardial perfusion imaging: The impact of achieved exercise level. J. Nucl. Cardiol. 2014. Vol. 21. No. 6. P. 1132-1143.
  75. Petretta M., Acampa W., Cuocolo A. Cardiovascular risk stratification in diabetic patients: Is all in METS? J. Nucl. Cardiol. Springer US. 2014. Vol. 21. No. 6. P. 1144-1147.
  76. Ghatak A., Padala S., Katten D.M. et al. Risk stratification among diabetic patients undergoing stress myocardial perfusion imaging. J. Nucl. Cardiol. 2013. Vol. 20. No. 4. P. 529-538.
  77. Takanao U., Kazuya T., Hirofumi M. et al. Prognostic Value of Normal Stress-Only Technetium-99m Myocardial Perfusion Imaging Protocol. Circ. J. Circ. J. Off. J. Japanese Circ. Soc. 2012. Vol. 76. No. 10. P. 2386-2391.
  78. Boiten H.J., van Domburg R.T., Valkema R. et al. Dobutamine stress myocardial perfusion imaging: 8-year outcomes in patients with diabetes mellitus. Eur. J. Cardiovasc. Imaging. 2016. Vol. 17. No. 8. P. 871-876.

For citation: Kharina DS, Poletaeva TA, Kondakov AK, Mosin DYu, Nikitin AE, Znamensky IA. Nuclear Medicine in Diagnosis of Angiopathy in Patients with Diabetes Mellitus Type 2. Medical Radiology and Radiation Safety. 2017;62(1):56-64. Russian. DOI: 10.12737/25062

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