JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2021. Vol. 66. № 5. P. 95–100
Estimation of Radiotherapy Efficiency of Head-and-Neck Cancer Based on Tumor Control Probability Model
Е.S. Sukhikh1,2, L.G. Sukhikh 2, Ya.N. Sutygina1,2, P.V. Izhevsky3, I.N. Sheino3, O.M.Stakhova2,4, M.I. Klinovitskaya2
1Tomsk Regional Oncology Center, Tomsk, Russia
2National Research Tomsk Polytechnic University, Tomsk, Russia
3 A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
4Multidisciplinary Clinical Medical Ccenter “Medical city”, Tyumen, Russia
Contact person: Olga Mikhailovna Stakhova: This email address is being protected from spambots. You need JavaScript enabled to view it. .
ABSTRACT
Purpose: Evaluation of the expected effectiveness of radiation therapy based on models of the local tumor control probability (Tumor Control Probability – TCP) for the head-neck cancer.
Material and мethods: The study used data from 11 patients with locally advanced head-neck cancer (larynx, oropharynx, and oral cavity). For each patient two dosimetric treatment plans have been prepared: SIB-VMAT (70 Gy per tumor, 50 Gy per lymph nodes, 25 fractions) and SEQ-VMAT (70 Gy per tumor, 50 Gy per lymph nodes, 35 fractions). The developed plans were analyzed using A. Niemierko's TCP model with parameters obtained by B. Maciejewski (TCD50 = 70.26 Gy with a 49-day total treatment time), taking into account the dose–volume histograms and the total treatment time.
Results: The developed plans ensured a high level of coverage (98–98 %) of the Clinical treatment volume (CTV) in all but one patient. The average TCP SIB-VMAT is 99.9 % due to the very short total treatment time. The average TCP for SEQ-VMAT is 61.0%. For one patient, both SIB-VMAT and SEQ-VMAT showed zero expected efficacy due to 95–95 % CTV coverage.
Conclusion: The use of TCP model allows analyzing personalized treatment plans for patients and developing adaptive treatment regimens with an increase in the total dose, dose per fraction, and a decrease in the total treatment time.
Key words: locally advanced cancer head and neck, volumetric modulated arc therapy, simultaneous integrated dose escalation, tumor control probability, TCP model
For citation: Sukhikh ЕS, Sukhikh LG, Sutygina YaN, Izhevsky PV, Sheino IN, Stakhova OM, Klinovitskaya MI. Estimation of Radiotherapy Efficiency of Head-and-Neck Cancer Based on Tumor Control Probability Model. Medical Radiology and Radiation Safety 2021;66(5):95-100.
DOI: 10.12737/1024-6177-2021-66-5-95-100
References
1. Каприн А.Д, Старинский В.В, Петрова Г.В. Злокачественные новообразования в России в 2017 году. Заболеваемость и смертность. 2018. Available from: http://www.oncology.ru/service/statistics/malignant_tumors/2017.pdf.
2. Beitler JJ, Zhang Q, Fu KK, Trotti A, Spencer SA, Jones CU, et al. Final Results of Local-Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer // International Journal of Radiation Oncology Biology Physics. 2014. V.89, No. 1. P. 13–20. DOI: 10.1016/j.ijrobp.2013.12.027. PMID: 24613816.
3. Dragan T., Beauvois S, Moreau M, Paesmans M, Vandekerkhove C, Cordier L, et al. Clinical Outcome and Toxicity after Simultaneous Integrated Boost IMRT in Head and Neck Squamous Cell Cancer Patients // Oral Oncology. 2019. No. 98. P. 132–140. DOI: 10.1016/j.oraloncology.2019.09.012. DOI: 10.1016/j.oraloncology.2019.09.012. PMID: 31586895.
4. Maciejewski B, Withers HR, Taylor JMG, Hliniak A. Dose Fractionation and Regeneration in Radiotherapy for Cancer of the Oral Cavity and Oropharynx: Tumor Dose-Response and Repopulation // International Journal of Radiation Oncology, Biology, Physics. 1989. V.16, No. 3. P. 831–843. DOI: 10.1016/0360-3016(89)90503-8. PMID: 2921175.
5. Orlandi E, Palazzi M, Pignoli E, Fallai C, Giostra A, Olmi P. Radiobiological Basis and Clinical Results of the Simultaneous Integrated Boost (SIB) in Intensity Modulated Radiotherapy (IMRT) for Head and Neck Cancer: A Review // Critical Reviews in Oncology/Hematology. 2010. V.73, No. 2. P. 111–125. DOI: 10.1016/j.critrevonc.2009.03.003. PMID: 19409808.
6. Chao KSC, Ozyigit G, Tran BN, Cengiz M, Dempsey JF, Low DA. Patterns of Failure in Patients Receiving Definitive and Postoperative IMRT for Head-and-Neck Cancer // International Journal of Radiation Oncology Biology Physics. 2003. V.55, No. 2. P. 312–321. DOI: 10.1016/s0360 -3016(02)03940-8. PMID: 12527043.
7. Spiotto MT, Weichselbaum RR Comparison of 3D Confromal Radiotherapy and Intensity Modulated Radiotherapy with or Without Simultaneous Integrated Boost During Concurrent Chemoradiation for Locally Advanced Head and Neck Cancers // PLoS ONE. 2014. V.9, No. 4. DOI: 10.1371/journal.pone.0094456. PMID: 24714187.
8. Vlacich G, Stavas MJ, Pendyala P, Chen SC, Shyr Y, Cmelak AJ. A Comparative Analysis Between Sequential Boost and Integrated Boost Intensity-Modulated Radiation Therapy with Concurrent Chemotherapy for Locally-Advanced Head and Neck Cancer // Radiation Oncology. 2017. V.12, No. 1. DOI: 10.1186/s13014-016-0756-x. PMID: 28086954.
9. Vanasek J, Odrazka K, Dusek L, Jarkovsky J, Michalek R, Chrobok V, et al. Experience with Intensity-Modulated Radiotherapy in the Treatment of Head and Neck Cancer // Journal of BUON. 2013. V.18, No. 4. P. 970–976. PMID: 24344025.
10. Farrag A, Voordeckers M, Tournel K, De Coninck P, Storme G. Pattern of Failure after Helical Tomotherapy in Head and Neck Cancer // Strahlentherapie und Onkologie. 2010. V.186, No. 9. P. 511–516. DOI: 10.1007/s00066-010-2130-5. PMID: 20803182.
11. Barry MA, Hussein M, Schettino G. Evaluating the Propagation of Uncertainties in Biologically Based Treatment Planning Parameters // Front. Oncol. 2020. DOI: 10.3389/fonc.2020.01058. PMID: 32793468.
12. Niemierko A. Reporting and Analyzing Dose Distributions: A Concept of Equivalent Uniform Dose // Medical Physics. 1997. V.24, No. 1. P. 103–110. DOI: 10.1118/1.598063. PMID: 9029544.
13. Gay HA., Niemierko A A. Free Program for Calculating EUD-Based NTCP and TCP in External Beam Radiotherapy // Physica Medica. 2007. No. 3-4. P. 115–125. DOI: 10.1016/j.ejmp.2007.07.001. PMID: 17825595.
14. Bigelow EO, Seiwert TY, Fakhry C. Deintensification of Treatment for Human Papillomavirus-Related Oropharyngeal Cancer: Current State and Future Directions // Oral Oncology. 2020. No. 105. DOI: 10.1016/j.oraloncology.2020.104652. PMID: 32247987.
15. Fakhry C, Zhang Q, Gillison ML, Nguyen-Tân PF, Rosenthal DI, Weber RS, et al. Validation of NRG Oncology/RTOG-0129 Risk Groups for HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Cancer: Implications for Risk-Based Therapeutic Intensity Trials // Cancer. 2019. V.125, No. 12. P. 2027–2038. DOI: 10.1002/cncr.32025. PMID: 30913305.
16. Overgaard J, Hansen HS, Specht L, Overgaard M, Grau C, Andersen E, et al. Five Compared with Six Fractions Per Week of Conventional Radiotherapy of Squamous-Cell Carcinoma of Head and Neck: DAHANCA 6&7 Randomised Controlled Trial // Lancet. 2003. V.362, No. 9388. P. 933–940. DOI: 10.1016/s0140-6736(03)14361-9. PMID: 14511925.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 23.12.2020.
Accepted for publication: 20.01.2021.