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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 1. P. 49-55
DOI: 10.12737/25059
To Improve Accuracy of Radionuclide Therapy Dosimetry Planning Using Monte Carlo Method
Yu.V. Lysak1, M.O. Goncharov2, B.Ya. Narkevich2,3, S.V. Shiryaev2
1. National Research Nuclear University MEPhI, Moscow, Russia; 2. N.N. Blokhin Cancer Research Center, Moscow, Russia; 3. Institute of Medical Physics and Engineering, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Yu.V. Lysak - Post-graduate student MEPhI; M.O. Goncharov - Radiologist in Nuclear Medicine Laboratory of N.N. Blokhin Russian Cancer Research Center; B.Ya. Narkevich - Leading Researcher in Nuclear Medicine Laboratory of N.N. Blokhin Russian Cancer Research Center, D. Sc. Tech., Prof.; S.V. Shiryaev - Head of Nuclear Medicine Laboratory of N.N. Blokhin Russian Cancer Research Center, D. Sc. Med., Prof.
Abstract
Purpose: Development and clinical testing of methodology dosimetry planning of radionuclide therapy based on Monte Carlo simulation of radiation transfer process.
Material and methods: The method of determination in absolute units of radiopharmaceutical (RP) activity accumulated in tumor lesions. The technique is based on scintigraphy syringe containing diagnostic RP activity, biplane patient scintigraphy after injection of the RP and determination of the RP accumulation when administered calculated using the Monte Carlo method for the absorption and scattering of radiation in the patient’s body and in the collimator of the gamma camera. Code MCNP Monte Carlo simulation was used. The layout of determination of the value of accumulated RP activity in the patient’s tumor site implies successive implementation of the following three steps.
- Scintigraphic images are obtained of the vial containing already known activity of the RP placed at the fixed source-to-collimator distance, following which estimation of the detector count rate within the specified region of interest of the vial image is undertaken.
- Therapeutic activity A0 is introduced in the patient’s body, scintigraphic examination of the patient is performed. Estimation of the detector count rate in the region where the tumor is located and the value of tissue background in the close enough vicinity to the tumor is performed using the tools for contouring the region of interest on the obtained planar image provided using the software imbedded in the scintigraphic equipment.
- Value of accumulated activity RP in the affected tumor is determined according to the correction factor which is calculated using Monte-Carlo method for specific clinical case for the geometry used in obtaining scintigraphic images which is identical to the conditions of measurement of activity in the vial and in the patient’s body.
The technique has been tested in the study, with an injection of 30 MBq of 123I-MIBG child with neuroblastoma.
Results: The level of accumulation of radiopharmaceutical in the tumor of the adrenal gland was 0.78 MBq, i.e. 2.6 % of the administered activity. This corresponds to literature data (average about 2.4 %) for scintigraphic studies of children with neuroblastomas. When using the known calculation method for analytical formula without the introduction of corrections for the absorption and scattering of radiation was obtained a result of 1.02 MBq, i.e. overestimation was 31 %.
Conclusions: Introduction calculated by the Monte Carlo method for the absorption and scattering of radiation during scintigraphy patient can improve the accuracy of dosimetry planning of radionuclide therapy.
Key words: radionuclide therapy, dosimetry planning, tumor foci, radiopharmaceutical accumulation, activity determination, Monte-Carlo method
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For citation: Lysak YuV, Goncharov MO, Narkevich BYa, Shiryaev SV. To Improve Accuracy of Radionuclide Therapy Dosimetry Planning Using Monte Carlo Method. Medical Radiology and Radiation Safety. 2017;62(1):49-55. Russian. DOI: 10.12737/25059
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