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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2022. Vol. 67. № 1
Reirradiation of High-Grade Brain Gliomas:
Availability and Risks. Literature Review
K.E.Medvedeva, I.A.Gulidov, D.V.Gogolin
A.F. Tsyb Medical Radiological Research Centre, Obninsk, Russia
Contact person: Medvedeva Kira Evgenievna: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
High-grade gliomas are the most common type of primary brain tumor in adults. A distinctive feature of malignant gliomas is their high aggressiveness, resistance to various types of treatment, and high recurrence rate. Depending on the grade of malignancy, a relapse can occur in months or years, however, it is inevitable for almost all patients with this type of tumor. Despite the improvement of treatment methods, the problem of recurrence of malignant brain gliomas remains relevant: reoperation is associated with the risk of developing severe neurological deficits, and previous chemotherapy often leads to severe hematological toxicity. Thus, re-irradiation is seen as an effective treatment option for tumor recurrence.
This review of the scientific literature examines various aspects of re-irradiation of high-grade gliomas, provides data on the features of diagnosis and treatment results in patients, as well as the frequency of complications.
Keywords: high-grade brain gliomas, recurrence, proton therapy, reirradiation
For citation: Medvedeva KE, Gulidov IA, Gogolin DV. Reirradiation of High-Grade Brain Gliomas: Availability and Risks. Literature Review. Medical Radiology and Radiation Safety. 2022;67(1):77-82.
DOI: 10.12737/1024-6177-2022-67-1-77-82
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 17.07.2021.
Accepted for publication: 05.09.2021