JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-5-9
F.E. Ismailova, S.E. Nagieva, E.R. Nagiev
Research of the Activity of Glutathionperoxidase and the Content of Glutathion in Various Structural and Functional Divisions of the Radrain Brain when Exposed to Radiation
Dagestan State Medical University, Makhachkala, Russia
Contact person: E.R. Nagiev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the specific content (per 1 g of tissue) of reduced glutathione and the activity of the enzyme of antioxidant protection glutathione peroxidase conjugated with it in various structural and functional parts of the rat brain when exposed to ionizing radiation at a dose of 6 Gy.
Material and methods: The studies were carried out on white outbred rats subjected to a single total γ-radiation at an average lethal dose of 6 Gy. The content of reduced glutathione and the activity of glutathione peroxidase were determined in various structural and functional parts of the brain of irradiated animals: cortex, brain stem, and cerebellum. A group of non-irradiated intact rats served as a control.
Results: In control animals, the activity of glutathione peroxidase in the cytoplasm is significantly higher than in mitochondria obtained from cells of the cortex, cerebellum, and brain stem. The content of reduced glutathione in control rats is highest in the cerebral cortex, followed by the cerebellum and brainstem. Significant violations of the studied biochemical parameters in the cerebral cortex, brainstem and cerebellum were found in the dynamics of radiation damage. Thus, in particular, the content of reduced glutathione in the cerebral cortex of rats on the 7th day after radiation exposure decreases to approximately 66 % compared with the indicators of the control group of animals.
Conclusions: Exposure to radiation at a dose of 6 Gy leads to a decrease in the content of the antioxidant glutathione in various structural and functional parts of the rat brain, especially on the 7th day after radiation injury. The detected changes in the glutathione content in the dynamics of acute radiation sickness correlate with changes in the activity of glutathione peroxidase, an enzyme directly coupled to this antioxidant.
Key words: glutathione, glutathione peroxidase, ionizing radiation, brain, cortex, brain stem, cerebellum, rats
For citation: Ismailova FE, Nagieva SE, Nagiev ER. Research of the Activity of Glutathionperoxidase and the Content of Glutathion in Various Structural and Functional Divisions of the Radrain Brain when Exposed to Radiation. 2022;67(5):5–9. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-5-9
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.