JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Incidence and Mortality from Central Nervous System Tumors
in the Cohort of Workers Chronically Exposed to Radiation
M.B. Moseeva, T.V. Azizova, M.V. Bannikova
Southern Urals Biophysics Institute of the Federal Medical Biological Agency, Ozyorsk, Russia.
Contact person: Azizova Tamara Vasilievna, This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To analyze incidence and mortality rates of central nervous system (CNS) primary tumors (PT) in the cohort of workers chronically exposed to radiation.
Material and methods: Study cohort included 22237 Mayak Production Association workers. Work history data and dose estimates from the “Mayak Worker Dosimetry System 2013” were used. Clinical and epidemiology data were obtained from the “Clinic” database. Crude and age-adjusted (by indirect method) incidence and mortality rates for CNS PT per 100000 person-years were calculated. Standardized incidence and mortality trends were analyzed by Jointpoint 4.0.4.
Results: 53 cases and 47 deaths from malignant neoplasms (MN) of brain and spinal cord, cerebral nerve and other parts of CNS (C70–C72 ICD-10 codes) as well as 40 cases and 7 deaths from non-malignant neoplasms (NMN) of brain and other parts of CNS (D-33 ICD-10 code) were identified. CNS MN were more frequent among males (83 %), and CNS NMN were more frequent among females (55 %). Both CNS MN and NMN developed at younger ages among males as compared with females, CNS PT frequency increased with increased attained age. Analysis in relation to calendar period revealed the increasing trend for CNS PT incidence among females only (р=0,008). Effects of chronic occupational radiation exposure on CNS PT incidence and mortality rates were not established either among males or females.
Conclusion: Findings should be considered as preliminary and require further studies.
Keywords: workers, chronic radiation exposure, central nervous system, primary tumors, malignant neoplasms, non-malignant neoplasms
For citation: Moseeva MB, Azizova TV, Bannikova MV. Incidence and Mortality from Central Nervous System Tumors in the Cohort of Workers Chronically Exposed to Radiation. Medical Radiology and Radiation Safety. 2022;67(4):42-48. DOI: 10.33266/1024-6177-2022-67-4-42-48
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 15.03.2022. Accepted for publication: 11.05.2022