JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Combined Treatment of Rectal Cancer Using Two-component Radiomodification with Neoadjuvant Radiation Therapy Together with a Chemotherapy
Yu.A. Barsukov1, S.I. Tkachev1, Z.Z. Mammadli1, V.A. Aliev1,
O.A. Vlasov2, N.D. Oltarzhevskaya3, M.A. Korovina3
1N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia
2Russian Scientific Center of Radiology and Nuclear Medicine, Ministry of Health of Russia, Moscow, Russia
3“Coletex” Ltd., Moscow, Russia
Contact person: Yu.A. Barsukov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: to evaluate the effectiveness of a “short” course of neoadjuvant radiation therapy using two radio modifiers with different mechanisms of radio-modulating action together with a drug therapy.
Material and methods: To increase the effectiveness of radiation therapy there was created a variant of combined treatment of patients with rectal cancer, using the concept of polyradiomodification. Two radio modifiers have been applied (local microwave hyperthermia and intrarectal Metronidazole administration as part of a polymer composition) together with neoadjuvant radiation therapy and oral administration of Capecitabine, followed by surgical intervention 4–6 weeks after the end of radiation therapy. For intrarectal delivery of Metronidazole to the tumor, a new medical device was created, which is a biopolymer composition in the form of a hydrogel with a Metronidazole substance physically immobilized in it (RF Patent No. 2007139304, 2007).
Results: The study included 520 patients, of whom 114 underwent a new variant of combined treatment with modulation of the effect of irradiation with two different radiomodifiers together with a drug therapy (group-1), 193 patients underwent only single-mode radiation therapy (group-2), and 213 patients underwent a combination of radiation therapy with local microwave hyperthermia (group-3). Toxic manifestations in group-1 was diagnosed in 38 (33,3 %) of 114 patients, general toxic manifestations of the III degree – in 13 (11,4 %) of 114. Postoperative complications in the group-1 was observed in 21 (18,4 %) of 114 patients, which was significantly less than in the group-2 and group-3, where they occurred in 78 (40,4 %) of 193 (p=0,0001) and in 78 (36,6 %) of 213 (p=0,0006). With a median follow-up of 54,6 months. relapses of cancer in the group-1 was not detected in any of 114 patients, which is significantly less than in the group-2, in which cancer relapses were diagnosed in 17 (8,8 %) of 193 patients (p=0,0011), and in the group-3, where they were detected in
10 (4,7 %) of 213 patients (p=0,0188). This made it possible to increase the number of sphincter-preserving operations performed in the group-1 to 84,2 %, which is significantly more compared to 53,4 % in the group-2 (p=0,00001) and 56,8 % in the group-3 (p=0,00001). It was also possible to significantly increase the rate of five-year relapse-free survival in the group-1 up to 82,9 % compared to 65,3 % at group-2 (p=0,01106) and 61,1 % at group-3 (p=0,00276).
Conclusion: The treatment option using polyradiomodification is effective in improving local antitumor control of the disease and increasing relapse-free survival rates compared to other combined treatment options.
Keywords: rectal cancer, combined treatment, radiomodifiers, therapeutic pathomorphosis, long-therm results
For citation: Barsukov YuA, Tkachev SI, Mammadli ZZ, Aliev VA, Vlasov OA, Oltarzhevskaya ND, Korovina MA. Combined Treatment of Rectal Cancer Using Two-component Radiomodification with Neoadjuvant Radiation Therapy Together with a Chemotherapy. Medical Radiology and Radiation Safety. 2022;67(4):69-73. (In Russian) DOI:10.33266/1024-6177-2022-67-4-69-73
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 17.01.2022. Accepted for publication: 15.03.2022.