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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 6. P. 12-20
RADIATION BIOLOGY
DOI: 10.12737/article_5a251dd2e01c02.38141187
Plutonium-239 Dioxide in the Lung. Report 2: Pathology of the Lungs of Rats Induced by Intratracheal Injection of Plutonium-239 Dioxide
E.S. Zhorova, I.K. Belyaev, V.S. Kalistratova, I.M. Parfenova, G.S. Tischenko, V.P. Saprykin, A.S. Samoylov
A.I. Burnasyan Federal Medical Byophisical Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
E.S. Zhorova – Leading Researcher, PhD Biol.; I.K. Belyaev – Head of Lab., PhD Biol.; V.S. Kalistratova – Leading Researcher, Dr. Sc. Med.; I.M. Parfenova – Research Fellow; G.S. ѩschenko – Researcher Fellow; V.P. Saprykin – Head of Lab., Dr. Sc. Med., Prof.; A.S. Samoylov – Director General of FMBC, Dr. Sc. Med.
Abstract
Purpose: The study of lung pathology induced by intratracheal injection of plutonium-239 dioxide and obtaining actual data on the dose-dependent profile of the remote consequences.
Material and methods: The plutonium dioxide was introduced into nonlinear white male rats once intratracheally in the amount of 100 kBq/kg body weight. Experimental animals were observed during their whole life. Radiometric, histoautoradiographical, histological and statistical research methods were used. Indicators of lung pathology were inflammatory, sclerotic, precancerous and neoplastic changes in the lungs.
Results: The calculation of absorbed doses in the lungs showed their variety from 1 to 400 Gy. The paper presents a quantitative analysis of remote lung pathology according to the groups with average absorbed doses from 7 to 306 Gy. The introduction of 239PuO2 significantly increased the frequency of sclerotic changes of the lungs compared with intact rats (11 and 46 %, respectively). Tumors were found in the lungs of 20 % of intact rats and of 51 % of the rats that received 239PuO2. Malignant neoplasm of epithelial origin prevailed. They were formed in 9 % of the biological control rats and in 41 % of the rats, carriers of 239PuO2. The dependence of the frequency of pathological changes in the lungs from absorbed dose in the organ was revealed.
Conclusion: A single intratracheal introduction of 239PuO2 has increased the frequency of pathological changes in the lungs of rats compared with intact animals. With the increase of the absorbed dose in the lungs the number of rats with pneumosclerosis, tumors of epithelial origin and multiple tumors has grown. Most indicative are adenocarcinoma and squamous-cell carcinomas. With the increasing of absorbed dose not only the frequency, but a spectrum of tumors varies. Dose response – probability of effect for each type of non-neoplastic and neoplastic pathology has its own character. For tumors of hematopoietic and lymphoid tissue, localized in the lungs, the opposite from tumors of epithelial origin, dependence of the frequency of their formation from the absorbed dose has been revealed.
Key words: the plutonium dioxide, intratracheal injection, rats, absorbed doses, pathology of the lungs
REFERENCES
- Moskalev Yu.I. Radiobiologiya inkorporirovannyh radionuklidov. Moscow: Energoatomizdat. 1989. 264 p. (In Russ.).
- Buldakov L.A., Vasilenko I.YA., Kalistratova V.S. et al. Radionukidy i proizvodstvennaya deyatel’nost’ cheloveka. Moscow. 1999. 160 p. (In Russ.).
- Kalistratova V.S., Belyaev I.K., Zhorova E.S. et al. Radiobiologiya inkorporirovannyh radionuklidov. Pod red. V.S. Kalistratovoj. Moscow. Publ. FMBC im. A.I. Burnazyana FMBA Rossii. 2012. 464 p. (In Russ.).
- Plutonij. Radiacionnaya bezopasnost’. Pod red. L.A. Il’ina. Moscow: IzdAT. 2005. 416 p. (In Russ.).
- Lyubchanskij E.R., Kuz’menko O.V., Osovec S.V., Sokolova S.N. Prognoznye ocenki metabolizma i kancerogennogo dejstviya α-izluchatelej (234,235U, 237Np, 239Pu, 241Am) v lyogkih i skelete cheloveka: obobshchenie ehksperimental’nyh dannyh, poluchennyh na razlichnyh biologicheskih modelyah. Ozyorsk. 2011. 304 p. (In Russ.).
- Belyaev I.K., Elatonceva N.B., Zarajskij A.V., Popov B.A. Kolichestvennye zakonomernosti modeli vnutritraheal’nogo vvedeniya v ehksperimente. Radiobiologiya. 1988. Vol. 28. No. 3. P. 396–400. (In Russ.).
- Bochvar I.A., Pashkova T.A. Rekomendacii po opredeleniyu aktivnosti plutoniya-239 v probah organov i tkanej ehksperimental’nyh zhivotnyh s pomoshch’yu avtomaticheskogo zhidkostnogo schetchika Del’ta-300. IBF MZ SSSR. Inv R-362. Moscow. 1984. 5 p. (In Russ.).
- Sanders C.L., Dagle G.E., Cannon W.C. et al. Inhalation carcinogenesis of high-fired 239PuO2 in rats. Radiat. Res. 1976. Vol. 68. No. 2. P. 349–360.
- Sanders C.L., Mahaffey J.A. Action of vitamin C on pulmonary carcinogenesis from 239PuO2. Health Phys. 1983. Vol. 45. No. 3. P. 794–798.
- Lakin G.F. Biometriya. Moscow: Vysshaya shkola. 1980. 293 p. (In Russ.).
- Maleta Yu.S., Tarasov V.V. Neparametricheskie metody statisticheskogo analiza v biologii i medicine. Moscow. Publ. Izd-vo Mosk. un-ta. 1982. 178 p. (In Russ.).
- Maleta Yu.S., Tarasov V.V. Matematicheskie metody statisticheskogo analiza v biologii i medicine. Moscow. Publ. Mosk. un-ta. 1981. 176 p. (In Russ.).
- Zhorova E.S., Zalikin G., Nisimov P.G. Gistopatologiya legkih krys pri porazhenii 238Pu . Radiobiologiya. 1989. Vol. 29. No. 2. P. 202–206. (In Russ.).
- Greenberg A., Yee H., Rom W. Preneoplastic lesions of the lung. Resp. Res. 2002. Vol. 3. No. 1. P. 1–10.
- Pankiewicz W., Minarowski L., Nikliñska W. et al. Immunohistochemical markers of cancerogenesis in the lung. Fol. Histochem. Cytobiol. 2007. Vol. 45. No. 2. P. 65–74.
- Moskalev Yu.I., Zalikin G.A., Nisimov P.G. et al. Problemy radiobiologii 238Pu. Moscow: Energoatomizdat. 1990. 168 p. (In Russ.).
For citation: Zhorova ES, Belyaev IK, Kalistratova VS, Parfenova IM, Tischenko GS, Saprykin VP, Samoylov AS. Plutonium-239 Dioxide in the Lung. Report 2: Pathology of the Lungs of Rats Induced by Intratracheal Injection of Plutonium-239 Dioxide. Medical Radiology and Radiation Safety. 2017;62(6):12-20. Russian. DOI: 10.12737/article_5a251dd2e01c02.38141187
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