JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-59-63
D.V. Kuzmichev1, Z.Z. Mamedli1, M.V. Chernih2, A.A. Tryakin3,
A.V. Polinovskiy1, V.A. Aliev1,N.A. Kozlov4, A.A. Aniskin1
NEOADJUVANT CHEMORADIOTHERAPY WITH CONSOLIDATION CHEMOTHERAPY IMPROVES THE SURVIVAL OF PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER
1Department of Coloproctology of RCRC N.N. Blokhin, Moscow, Russia
2Department of Radiation Oncology of RCRC N.N. Blokhin, Moscow, Russia
3Department of Chemotherapy of RCRC N.N. Blokhin, Moscow, Russia
4Department of Pathological anatomy of human tumors of RCRC N.N. Blokhin, Moscow, Russia
Contact person: Dmitriy Vladimirovich Kuzmichev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Consideration of the long-term three-year results of combined treatment of patients with locally advanced rectal cancer using preoperative chemoradiotherapy and consolidating chemotherapy.
Material and methods: Patients aged >18 with histologycally verified MRI-staged low and medium T3(CRM+)‒4N0‒2M0 rectal cancer were included. In the study group patients received neoadjuvant chemoradiotherapy 52‒56 Gy in 2 Gy fractions with capecitabine 850 mg/m2 per os two times a day and followed by 4 cycles in СapOx regimen. In the control group, similar chemoradiotherapy was performed without consolidating chemotherapy. The study group consisted of 105 patients, and the control group consisted of 99 patients. The median follow-up was
42.4 months.
Results: The full planned course of preoperative treatment was carried out in 201 (98.5 %) patients. Progression of the disease after the neoadjuvant therapy was not detected in any patient. A complete pathological response in the tumor was registered in 29 (15.1 %) patients, and a complete clinical response in 12 (6 %) patients. In the study and control groups, these indicators were (20 % vs. 10.3 %, p=0.04) and (9.5 % vs. 2 %, p=0.01), respectively. Local relapses in the study were registered in 18 (8.8 %) patients, and distant metastases in
53 (26 %) patients. In the study and control groups, local relapse and distant metastases developed in 4.8 % vs. 13.1 % (p=0.03) and
20 % vs. 32.3 % (p=0.04), respectively. The overall three-year survival rate in patients in the study group was 92.9 %, in the control group
79.7 % (HR 0.2, 95 % CI 0.03‒0.24, p=0.01). Three-year relapse-free survival in patients in the study group was 75.5 %, and in the control group 59.6 % (HR 0.2, 95 % CI 0.05‒0.32, p=0.01).
Conclusion: Up to date, the strategy of combined neoadjuvant treatment seems to be the most promising. With a high degree of probability, this approach in the treatment of patients with locally advanced rectal cancer may become a new standard of therapy with a similar treatment algorithm.
Keywords: locally advanced rectal cancer, consolidating chemotherapy, neoadjuvant chemoradiotherapy, pathomorphosis
For citation: Kuzmichev DV, Mamedli ZZ, Chernih MV, Tryakin AA, Polinovskiy AV, Aliev VA,Kozlov NA, Aniskin AA. Neoadjuvant Chemoradiotherapy with Consolidation Chemotherapy Improves the Survival of Patients with Locally Advanced Rectal Cancer. Medical Radiology and Radiation Safety. 2022;67(5):59–63. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-59-63
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.