JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 5
DOI: 10.33266/1024-6177-2022-67-5-64-68
V.V. Velikaya, Zh.A. Startseva, V.A. Lisin, V.E. Goldberg,
N.O. Popova
ADJUVANT NEUTRON THERAPY IN COMBINED MODALITY TREATMENT OF PATIENTS WITH PRIMARY-METASTATIC BREAST CANCER
Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia
Contact person: V.V. Velikaya, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To present long-term results adjuvant neutron therapy in combined modality treatment of patients with primary-metastatic breast cancer.
Material and methods: The studied included 53 patients with stage T2-4N1-3M1 breast cancer, who underwent multimodality treatment: neoadjuvant chemotherapy (NACT) and adjuvant chemotherapy (ACT) according to CMF, CAF/FAC schemes, antiestrogen therapy
(if indicated), radical mastectomy (RM) and radiotherapy using different types of ionizing radiation, from 2007 to 2018. All patients were divided into two groups. Group I patients (n = 23) underwent neutron therapy delivered to the anterior chest and group II patients
(n = 30) received photon therapy.
Results: The 6-year disease-free survival rate was 93.7 ± 6.1 % in patients who received adjuvant neutron therapy and 67.8 ± 7.6 % in patients who received photon therapy (p = 0.047). The overall 6-year survival rates in groups I and II were 68.9 ± 7.8 % and 45.9 ± 6.9, respectively (p = 0.36). Neutron therapy was well tolerated by all breast cancer patients.
Conclusion: In patients with stage T2-4N1-3M1 breast cancer neutron therapy as a dense ionizing radiation is more effective due to its biological characteristics. Radical surgery combined with chemotherapy is known to improve survival of breast cancer patients
Keywords: metastatic breast cancer, combined modality treatment, radical mastectomy, radiation therapy, neutron therapy, local recurrence, radiation-induced injuries, survival
For citation: Velikaya VV, Startseva ZhA, Lisin VA, Goldberg VE, Popova NO. Adjuvant Neutron Therapy in Combined Modality Treatment of Patients with Primary-Metastatic Breast Cancer. Medical Radiology and Radiation Safety. 2022;67(5):64–68. (In Russian). DOI: 10.33266/1024-6177-2022-67-5-64-68
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.06.2022. Accepted for publication: 25.08.2022.