JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 1
DOI: 10.33266/1024-6177-2023-68-1-15-18
D.V. Saleeva1, L.M. Rozhdestvensky1, N.F. Raeva1, E.S. Vorobeva1,
G.D. Zasukhina1,2
Mechanisms of Antitumor Activity of Low Doses of Radiation Associated with Activation of Cells’ Defense System
1A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2Institute of General Genetics, Moscow, Russia
Contact person: D.V. Saleeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Background: The effects of ionizing radiation (IR) involve a highly orchestrated series of events in cells, including DNA damage and repair, cell death, and changes in the level of proliferation associated with the stage of the cell cycle. A large number of existing studies in literature have examined the activity of genes and their regulators in mammalian cells in response to high doses of ionizing radiation. Although there are many studies, the research in effect of low doses of ionizing radiation remains limited. Though much progress has been made in understanding the basic principles of effects of low doses radiation on individual components of biological systems, less is known about how low doses affect target molecules and regulate the cellular networks (e.g., activation of the immune system, genes and their regulators in the phenomenon of hormesis, the formation of an adaptive response). These observations determined the purpose of the work: to investigate the activity of genes and non-coding RNAs (long non-coding RNAs and microRNAs) in various organs of mice with transplanted Lewis carcinoma after low doses radiation.
Material and methods: 24 female mice C57Bl/6 were transplanted subcutaneously with Lewis carcinoma cells (105 cells in 0.2 ml of Hanks’ solution). Total 4-fold X-ray irradiation with an interval of 4 days at a dose of 0.075 Gy (0.85 Gy/min) was performed on the RUST M1 from 6 days after transplantation; the tumor size was measured daily. The mice were divided into the following groups: biocontrol, biocontrol+irradiation, tumor and tumor+irradiation. On the 19th day from the beginning of the experiment, the mice were euthanized. The expression profiles of mRNA genes, long non-coding RNAs and microRNAs controlling the response to radiation were determined in the bone marrow, thymus, spleen and tumor of mice.
Results: Fractionated low doses irradiation of mice with transplanted Lewis carcinoma caused a growth decrease of implanted tumour cells compared to the similar group without irradiation. At the same time, there was an activation of oncosuppressors, and a decrease in the activity of oncogenes in the thymus and spleen of mice with tumor and irradiation. In the tumor group, without irradiation, the number of activated oncogenes prevailed over the number of inactivated ones.
Conclusion: Thus, the low doses radiation exposure led to the activation of antitumor immunity in mice, which emerged in slowing tumor growth in animals and was represented in the induction of oncosuppressors and inhibition of oncogenes expression.
Keywords: low doses of radiation, Lewis carcinoma, non-coding RNA, oncogenes, oncosuppressors, mice
For citation: Saleeva DV, Rozhdestvensky LM, Raeva NF, Vorobeva ES, Zasukhina GD. Mechanisms of Antitumor Activity of Low Doses of Radiation Associated with Activation of Cells’ Defense System. Medical Radiology and Radiation Safety. 2023;68(1):15–18.
(In Russian). DOI: 10.33266/1024-6177-2023-68-1-15-18
References
1. Sharma D.N., Guleria R., Wig N., Mohan A., Rath G., Subramani V., et al. Low-Dose Radiation Therapy for COVID-19 Pneumonia: a Pilot Study. Br. J. Radiol. 2021;94;1126:20210187. DOI: 10.1259/bjr.20210187.
2. Ceyzériat K., Tournier B.B., Millet P., Dipasquale G., Koutsouvelis N., Frisoni G.B., et al. Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice. J. Alzheimers Dis. 2022;86;2:641-653. DOI: 10.3233/JAD-215510.
3. Lumniczky K., Impens N., Armengol G., Candéias S., Georgakilas A.G., Hornhardt S., et al. Low Dose Ionizing Radiation Effects on the Immune System. Environ. Int. 2021;149:106212. DOI: 10.1016/j.envint.2020.106212.
4. Dahl H., Eide D.M., Tengs T., Duale N., Kamstra J.H., Oughton D.H. et al. Perturbed Transcriptional Profiles after Chronic Low Dose Rate Radiation in Mice. PLoS One. 2021;16;8:e0256667. DOI: 10.1371/journal.pone.0256667. eCollection 2021.
5. Михайлов В.Ф., Салеева Д.В., Рождественский Л.М. и др. Активность генов и некодирующих РНК как подход к определению ранних биомаркеров радиоиндуцированного опухолеобразования у мышей // Генетика. 2021. Т. 57, № 10, С. 1131-1140. DOI: 10.31857/S0016675821100076. [Mikhaylov V.F., Saleyeva D.V., Rozhdestvenskiy L.M., et al. Activity of Genes and Non-Coding RNA as an Approach to Early Biomarkers Determination of Radiation-Induced Cancer in Mice. Genetika = Russian Journal of Genetics. 2021;57;10:1131-1140. DOI: 10.31857/S0016675821100076. DOI: 10.31857/S0016675821100076 (In Russ.)].
6. Herrera F.G., Romero P., Coukos G. Lighting up the Tumor Fire with Low-Dose Irradiation. Trends Immunol. 2022;43;3:173-179. DOI: 10.1016/j.it.2022.01.006.
7. Wan X., Fang M., Chen T., Wang H., Zhou Q., Wei Y., et al. The Mechanism of Low-Dose Radiation-Induced Upregulation of Immune Checkpoint Molecule Expression in Lung Cancer Cells. Biochem. Biophys. Res. Commun. 2022;608:102-107. DOI: 10.1016/j.bbrc.2022.03.158.
8. López-Nieva P., González-Vasconcellos I., González-Sánchez L., Cobos-Fernández M.A., Ruiz-García S., Pérez R.S., et al. Differential Molecular Response in Mice and Human Thymocytes Exposed to a Combined-Dose Radiation Regime. Scientific Reports. 2022;12:3144. DOI: https://doi.org/10.1038/s41598-022-07166-8.
9. Zhou L., Zhang X., Li H., Niu C., Yu D., Yang G., et al. Validating the Pivotal Role of the Immune System in Low-Dose Radiation-Induced Tumor Inhibition in Lewis Lung Cancer-Bearing Mice. Cancer Med. 2018;7;4:1338-1348. DOI: 10.1002/cam4.1344.
10. Brown G. Oncogenes, Proto-Oncogenes, and Lineage Restriction of Cancer Stem Cells. Int. J. Mol. Sci. 2021;22;18:9667. DOI: 10.3390/ijms22189667.
11. Qi Z., Guo S., Li C., Wang Q., Li Y., Wang Z. Integrative Analysis for the Roles of lncRNAs in the Immune Responses of Mouse PBMC Exposed to Low-Dose Ionizing Radiation. Dose-Response. 2020;18;1:1559325820913800. DOI:10.1002/cam4.1344.
12. Khan M.G.M., Wang Y. Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle. Cells. 2022;11;3:356. DOI:10.3390/cells11030356.
13. Rusin M., Ghobrial N., Takacs E., Willey J.S., Dean D. Changes in Ionizing Radiation Dose Rate Affect Cell Cycle Progression in Adipose Derived Stem Cells. PLoS One. 2021;16;4:e0250160. DOI: 10.1371/journal.pone.0250160.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out on the topic of the A.I. Burnazyan State Scientific Research Center «Technology-2» (state task No. 10.009.20.800) and on the topic of the N.I. Vavilov Institute of General Genetics of the Russian Academy of Sciences (state task No. 0112-2019-0002).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.09.2022. Accepted for publication: 25.11.2022.