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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2
DOI: 10.33266/1024-6177-2023-68-2-53-59
A.N. Koterov, L.N. Ushenkova, I.G. Dibirgadzhiev, M.V. Kalinina, A.P. Biryukov
The First Radioprotectors:
For in vivo Experiments the Official Historical Milestone is Postponed by Six Years
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Alexey N. Koterov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Historical essays in monographs, in reviews and in the introductions of experimental works on theme of the first studies of radioprotectors are considered. It was found that such studies began to be carried out only during the development and use of atomic weapons, but not during the previous order of 40 years of radiotherapy (with the exception of the effect of hypoxia as such, and not caused by drugs).
In most publications, the work of Patt H.M. et al., 1949 on the cysteine action (USA) is called as pioneer research, what is not quite right (it is only right for thiol compounds). A paper by Joseph Maisin (Belgium) in the journal ‘Acta Biologica Belgica’ which published only in 1941–1943 in the occupied Brussels, should be considered as a real milestone for animal experiments (Vol. III–IV. P. 117). In this study, referenced only in a single work (Bacq Z.M. et al., 1951), the radioprotective effect of p-aminobenzoic acid (PABA) was demonstrated in rodents. In the same year, the radioprotective effect of estrogens was shown in mice (Treadwelal A. DEG. et al., February 1943).
A brief summary of the stages of radioprotective agents study is presented, starting from 1942 (W.M. Dale et al.; protection of the enzyme in solution) and up to the 1954, when all the main classes of radioprotectors were discovered and the corresponding mechanisms of effects were proposed.
Keywords: radioprotective agents, first radioprotectors, history
For citation: Koterov AN, Ushenkova LN, Dibirgadzhiev IG, Kalinina MV, Biryukov AP. The First Radioprotectors: For in vivo Experiments, the Official Historical Milestone is Postponed by Six Years. Medical Radiology and Radiation Safety. 2023;68(2):53–59.
(In Russian). DOI: 10.33266/1024-6177-2023-68-2-53-59
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Article received: 20.11.2022. Accepted for publication: 25.01.2023.