JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 2
DOI: 10.33266/1024-6177-2023-68-2-75-79
G.V. Zhuntova, T.V. Azizova, M.V. Bannikova, E.S. Grigoryeva
Risk Factors for Esophageal Cancer in the Cohort of Nuclear Facility Workers
Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia
Contact person: Galina Vadimovna Zhuntova, e-mail:
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ABSTRACT
Purpose: To assess the influence of non-radiation factors and occupational radiation exposure on the incidence risk of esophageal cancer in nuclear workers considering various histological types of the cancer.
Material and methods: The study was designed as a retrospective analysis that considered data on the cohort of workers employed at reactors, radiochemical and plutonium production facilities of the Mayak Production Association (PA) who had been hired during 1948–1982. The total number of workers included in the cohort was 21645. Using the EPICURE software, the relative risk (RR) and excess relative risk of the esophageal cancer incidence per unit of the accumulated gamma dose from external exposure (ERR/Gy) were estimated based on the Poisson regression.
Results: By 31.12.2018, 47 esophageal cancers were reported in members of the study cohort; the majority of these cancers were squamous cell carcinomas. The incidence risk of esophageal cancer was lower in females than in males and it increased with attained age. The increased risk of esophageal cancer (all cases) was associated with current smoking (RR=12.6, 95 % CI 4.21, 42.13), gastroesophageal reflux disease (GERD) (RR=3.96, 95 % CI 1.60, 8.48), excess body weight and obesity (RR=1.21, 95 % CI 1.13, 2.08). The significantly increased RR of squamous cell esophageal carcinoma was found in current smokers and workers had GERD. The significantly increased RR of esophageal adenocarcinoma was found in current and former smokers. The risk of esophageal cancer (all cases and squamous cell carcinomas) was higher in workers who abused alcohol but the RR estimates were not statistically significant. A significant linear association of the esophageal cancer risk with gamma dose from external exposure was found: ERR/Gy=1.28 (95 % CI 0.21, 4.11) for all cases and ERR/Gy=1.01 (95 % CI 0.01, 3.95) for squamous cell carcinoma; these estimates are the risks adjusted for sex, age, smoking, alcohol, GERD and body mass index. No effect of occupational radiation exposure on the esophageal adenocarcinoma risk was found.
Conclusion: This study confirmed obtained earlier data on the impact of occupational external gamma exposure on the risk of esophageal cancer in Mayak PA workers. The estimates of ERR/Gy of external gamma-ray exposure were updated having made adjustments for the most important non-radiation factors.
Keywords: esophageal cancer, occupational radiation exposure, external gamma ray exposure, Mayak PA, risk factors, excess relative risk
For citation: Zhuntova GV, Azizova TV, Bannikova MV, Grigoryeva ES. Risk Factors for Esophageal Cancer in the Cohort of Nuclear Facility Workers. Medical Radiology and Radiation Safety. 2023;68(2):75–79. (In Russian). DOI: 10.33266/1024-6177-2023-68-2-75-79
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study was sponsored by the Federal Medical and Biological Agency of Russia.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.11.2022. Accepted for publication: 25.01.2023.