JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 4
DOI: 10.33266/1024-6177-2023-68-4-75-80
V.I. Kobylyansky1, T.V. Kudasheva2, M.G. Berezina2, T.M. Magomedov3
Studying the Aerodynamic Characteristics of the Macrotech
and Evaluation of the Possibilities of Its Use for Dynamic Aerosol Scintigraphy
1 Research Institute of Pulmonology, Moscow, Russia
2 Federal Scientific and Clinical Center, Moscow, Russia
3 Russian Research Institute of Physical, Technical and Radio Engineering Measurements, Zelenograd, Moscow region, Russia
Contact person: V.I. Kobylyansky, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction: The leading protective mechanism of the lungs is the processes of deposition of inhaled substances and mucociliary clearance (MCC), the optimal method for studying which is dynamic radioaerosol scintigraphy. are not available on the market. The applicant in this regard for a number of characteristics is the radiopharmaceutical from albumin, produced in the Russian Federation under the brand name Macrotech (M). It is used for perfusion scintigraphy to verify primarily pulmonary embolism and its ability to study deposition of inhalants and MCC has not been studied.
Purpose: To study the aerodynamic properties of M dispersion and to determine the possibilities of its use for dynamic radioaerosol scintigraphy of the lungs in order to assess the processes of deposition of inhaled substances and MCC.
Material and methods: To study the aerodynamic properties of M, on which the assessment of the deposition of inhaled substances and MCC significantly depends, we studied the dispersion of its particles in different states, and studied them in shape and morphology. An ultrasonic inhaler TuR USI-50 (Germany) generated an aerosol from a suspension of M in distilled water. To study the dispersion in air, laser spectrometry was used using the Spraytec Malvern Instruments system (Great Britain). The protein content in the initial suspension and dispersible aerosol, collected in the form of a condensate, was determined using an Immulite 2000 XPi immunochemical analyzer (Siemens, USA).The shape and morphology of the particles were studied using scanning electron microscopy using.
Results: The study of the aerodynamic properties of the dispersion of M indicated that its particles are involved in the dynamics of the movement of the airflow and the flight of water particles generated by the inhaler. The dispersity of the aerosol generated from the suspension M averaged about 5 μm and did not significantly depend on the concentration of the radiopharmaceutical and did not depend on the studied dispersion intensity and airflow rate set using an inhaler. The morphology of M particles was characterized by a complex shape and roughness.
Conclusion: The aerodynamic characteristics of M are not optimal for studying the processes of deposition and MCC. However, a final verdict requires a direct assessment of the deposition of the inhaled radioaerosol generated from this preparation.
Keywords: dynamic aerosol scintigraphy, albumin macroaggregates, macrotech, dispersion aerosol, shape and morphology of particles, inhalant deposition, mucociliary clearance
For citation: Kobylyansky VI, Kudasheva TV, Berezina MG, Magomedov TM. Studying the Aerodynamic Characteristics of the Macrotech and Evaluation of the Possibilities of Its Use for Dynamic Aerosol Scintigraphy. Medical Radiology and Radiation Safety. 2023;68(4):75–80. (In Russian). DOI:10.33266/1024-6177-2023-68-4-75-80
References
1. Krivonogov N.G., Zavadovskiy K.V. Radionuclide Diagnostics in Pulmonology. Natsionalnoye Rukovodstvo po Radionuklidnoy Diagnostike = National Guide on Radionuclide Diagnostics. V.2 v. Ed. Lishmanov Yu.B., Chernov V.I. Tomsk Publ., 2010. P. 163-190 (In Russ.).
2. Chokkappan K., Kannivelu A., Srinivasan S., Babut S.B. Review of Diagnostic Uses of Shunt Fraction Quantification with Technetium-99m Macroaggregated Albumin Perfusion Scan as Illustrated by a Case of Osler-Weber-Rendu Syndrome. Ann. Thorac. Med. 2016;11;2:155-160. doi: 10.4103/1817-1737.180020.
3. Kobylyanskiy V.I. Mukotsiliarnaya Sistema. Fundamentalnyyei Prikladnyye Aspekty = Mucociliary System. Fundamental and Applied Aspects. Moscow Binom Publ., 2008. 416 p. (In Russ.).
4. Kobylyanskiy V.I. Methods for Studying the Mucociliary System: Possibilities and Prospects. Terapevticheskiy Arkhiv = Therapeutic Archive. 2001;73;3:73-76 (In Russ.).
5. Grosser O.S., Ruf J., Kupitzm D., Pethe A., Ulrich G., Genseke P., et al. Pharmacokinetics of 99mTc-MAA- and 99mTc-HAS Microspheres Used in Pre-Radioembolization Dosimetry: Influence on the Liver–Lung Shunt. Journal of Nuclear Medicine. 2016;57;6:925-927. doi:10.2967/jnumed.115.169987.
6. Scheuch G., Bennett W., Borgström L., Clark A., Dalby R., Dolovich M., et al. Deposition, Imaging, and Clearance: What Remains to be Done? Journal of Aerosol Medicine and Pulmonary Drug. Delivery. 2010;23;Suppl 2:S39-S57. http://doi.org/10.1089/jamp.2010.0839.
7. Ball D.R., McGuiro B.E., Chapter 6. Benumof and Hagbergs Airway Management. 2013. P. 159-183. https://doi.org/10.1016/B978-1-4377-2764-7.00006-3.
8. Canziani L., Marenco M., Cavenaghi G., Manfrinato G., Taglietti A., Girella A., et al. Chemical and Physical Characterization of Macroaggregated Human Serum Albumin: Strength and Specificity of Bonds with 99mTc and 68Ga. Molecules. 2022;27:404. doi.org/ 10.3390/molecules27020404.
9. Ament S., Buchholz H.G., Bausbacher N., Brochhausen C., Graf F., Miederer M., et al. PET Lung Ventilation/Perfusion Imaging Using 68Ga Aerosol (Galligas) and 68Ga-Labeled Macroaggregated Albumin. V.194. Theranostics, Gallium-68, and Other Radionuclides. Recent Results in Cancer Research. Ed. Baum R., Rösch F. Springer, Berlin, Heidelberg, 2013. https://doi.org/10.1007/978-3-642-27994-2_22.
10. Gandhi S.J., Babu S., Subramanyam P., Shanmuga Sundaram P. Tc-99m Macro Aggregated Albumin Scintigraphy - Indications Other than Pulmonary Embolism: A Pictorial Essay. Indian J. Nucl. Med. 2013;28;3:152-62. doi: 10.4103/0972-3919.119546.
11. Fazio F. Clinical Radioaerosol Imaging. Bull. Eur. Phisiol. Resp. 1980;16:134-136.
12. Chambarlain M.J. Factor Influencing оn the Regionдk Deposition of Particles in Man. Clin. Sci. 1983;64:641-547.
13. Morgan W.K.C., Ahmad D., Chambarlain M.Y. The Effect of Exercise on an Inhaled Aerosol. Respir. Physiol. 1984;56:327-338.
14. Kobylyanskiy V.I., Artyushkin A.V. Sposob Opredeleniya Ekskretornoy Funktsii Legkikh = A Method for Determining the Excretory Function of the Lungs. A.s. No. 138982. 1986 (In Russ.).
15. Kobylyanskiy V.I. Sposob Opredeleniya Funktsii Mukotsiliarnogo Apparata Legkikh = A Method for Determining the Function of the Mucociliary Apparatus of the Lungs. A.s. No. 1602469. 1988 (In Russ.).
16. Persico M.G., Marenco M., De Matteis G., Manfrinato G., Cavenaghi G., Sgarella A., et al. 99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits. Contrast Media Mol. Imaging. 2020;22;2020:3629705. doi: 10.1155/2020/3629705.
17. Hung J.C., Redfern M.G., Mahoney D.W., Thorson L.M., Wiseman G.A. Evaluation of Macroaggregated Albumin Particle Sizes for Use in Pulmonary Shunt Patient Studies. J. Am. Pharm. Assoc. (Wash). 2000;40;1:46-51. doi: 10.1016/s1086-5802(16)31035-x.
18. Pempuev V.M., Cmιnchcnhoɞ V.N., TSɔic G. Xaιupoɞ. Physical and Some Radiochemical Properties of Albumin Microspheres Used in Radionuclide Diagnostics. Isotopenpraxis Isotopes in Environmental and Health Studies. 1979;15;1:22-25. DOI: 10.1080/10256017908544275 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2022. Accepted for publication: 27.03.2023.