SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 2. P. 5-12

DOI: 10.12737/article_58f0b9572d7131.31568909

Neuromediator Exchange Dynamics in Rats at Late Periods After Exposure to 60Co g-Rays

K.V. Belokopytova1,2, O.V. Belov1, V.N. Gaevsky1, V.B. Narkevich3, V.S. Kudrin3, E.A. Krasavin1, A.S. Bazyan4

1. Institute for Nuclear Research, Dubna, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Institute of Genetics, Physiology and Plant Protection of the Moldovan Academy of Sciences, Chisinau, Moldova; 3. FSBI Zakusov Institute of Pharmacology, Moscow, Russia; 4. Institute of Higher Nervous Activity and Neurophysiology of RAS, Moscow, Russia

K.V. Belokopytova - Junior Researcher; O.V. Belov - PhD in Biology, Head of Sector; V.N. Gaevsky - Leading Engineer; V.B. Narkevich - PhD in Medicine, Researcher; V.S. Kudrin - PhD in medicine, Head of Laboratory; E.A. Krasavin - Corr. Member RAS, Acad., D. Sc. Biol., Director of Laboratory; A.S. Bazyan - Prof., D. Sc. Biol., Head of Laboratory

Abstract

Purpose: Estimation of the 60Co γ-ray effect on the neuromediator exchange dynamics in the brain of rats of different age groups.

Material and methods: 20 male Sprague-Dawley rats with the weight of 190-210 g were used in the experiment. At the age of two months, animals were exposed to a single whole-body irradiation with 60Co γ-rays at the dose of 1 Gy. In 30 and 90 days after exposure, rats we killed by decapitation. The animals were tested at three and five months of age, respectively. The neuromediator exchange dynamics was estimated by measuring the concentrations of monoamines (dopamine, noradrenaline, and serotonin) and their metabolites in four brain regions including prefrontal cortex, hypothalamus, hippocampus, and striatum. The levels of substances were assessed using the high-performance liquid chromatography with electrochemical detection. The results of measurements were statistically analyzed with the one-way analysis of variance (ANOVA).

Results: Although the direct measurements seeking for changes at the same time points revealed a little effect of γ-rays on the monoamine metabolism, age-related dynamics of the neuromediator exchange was affected in many aspects. The most pronounced in alterations in the two-month monoamine exchange dynamics were observed in the prefrontal cortex, hypothalamus and hippocampus. It indicates the sensitivity of these brain structures to the action of γ-rays at doses about 1 Gy. In the prefrontal cortex, hippocampus and hypothalamus, radiation exposure affected dopamine and serotonin regulations in the manner that may indicate suppression of catecholamine degrading pathways dependent on monoamine oxidases A and B against the activation of metabolic processes associated with catechol-O-methyltransferase. The prefrontal cortex and hypothalamus additionally exhibited an accelerated decrease in levels of some neuromediators, as compared to the dynamics normally observed beyond the age of three months. At the same time, our study identified a resistance of striatal metabolic pathways to irradiation with γ-rays at the stated dose. A comparison of the obtained data with results of our previous experiments investigating the action of accelerated carbon ions confirmed our expectations that the effect of γ-rays on the dynamics of the neuromediator exchange is less pronounced than from heavy nuclei.

Conclusion: Made a hypothesis that, in the case of heavy ion exposure, more pronounced alterations in brain mediator systems lead to more intensive compensatory and regenerative processes in them. Consequently, it may change the normal dynamics of neuromediator exchange in the investigated post-irradiation periods and serve a reason not only for decrease but also for an abnormal increase in levels of monoamines and their metabolites after exposure. In general, results of the performed study contribute to understanding the neurotoxic effect of γ-rays in comparison with other radiation modalities that can potentially be useful for predicting late outcomes of cranial radiation therapy.

Key words: central nervous system, ionizing radiations, late effects, monoamines, metabolites

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For citation: Belokopytova KV, Belov OV, Gaevsky VN, Narkevich VB, Kudrin VS, Krasavin EA, Bazyan A.S. Neuromediator Exchange Dynamics in Rats at Late Periods after Exposure to 60Co y-Rays. Medical Radiology and Radiation Safety. 2017;62(2):5-12. Russian. DOI: 10.12737/article_58f0b9572d7131.31568909

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