JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5

DOI:10.33266/1024-6177-2023-68-5-60-64

E.A. Kodintseva1, 2, A.А. Akleyev3

Individualized Approach to the Formation of High Cancer Risk Groups Based on the Assessment of Immunological Indicators
in Chronically Exposed People

1 Urals Research Center for Radiation Medicine, Chelyabinsk, Russia

2 Chelyabinsk State University, Chelyabinsk, Russia

3 Southern-Urals State Medical University, Chelyabinsk, Russia


CONTENTS

 

Introduction

1. Main risk factors of radiation-induced carcinogenesis 

2. Stages of an individualized approach to the formation of high-risk groups for cancer 

3. Comprehensive medical examination of a patient 

4. Determination of risk of radiation-induced carcinogenesis 

5. Measures for prevention and (or) early diagnosis of radiation-induced malignant neoplasms 

6. Monitoring of immunity indicators in persons at high risk of radiation-induced carcinogenesis 

Conclusion

 

Keywords: chronic radiation exposure, the Techa river, parameters of immunity, high-risk groups for cancer

For citation: Kodintseva EA, Akleyev AА.Individualized Approach to the Formation of High Cancer Risk Groups Based on the Assessment of Immunological Indicators in Chronically Exposed People. Medical Radiology and Radiation Safety. 2023;68(5):60–64.
(In Russian). DOI:10.33266/1024-6177-2023-68-5-60-64

 

References

1. Akleyev AV. Population groups with high-risk of late radiation effects. Radiation and Risk. 1997;10:128–135 (In Russ.).

2. Principles of Formation of Groups of Increased Cancer Risk among the Population Exposed to Chronic Radiation Exposure: Methodological Recommendations. Ed. Akleyev A.V., Silkina L.A., Pashkov I.A., Kisselyov M.F. Chelyabinsk Publ., 2006. 10 p. (In Russ.).

3. Blinova E.A., Veremeyeva G.A. The Use of Genetic and Cytogenetic Markers for the Formation of Groups of Increased Oncological Risk in Radiation Exposure. Bulletin of Chelyabinsk State University. Biology. 2013;7;2:88–90 (In Russ.).

4. Krestinina L.Yu., Silkin S.S., Mikryukova L.D., Epifanova S.B., Akleyev A.V. Risk of Death from Solid Cancer among Residents of the Techa Riverside and the East Urals Radioactive Trace Areas Exposed to Radiation: Comparative Analysis. Radiation and Risk. 2017;26;1:100–114 (In Russ.). DOI: 10.21870/0131-3878-2017-26-1-100-114.

5. Bushmanov A.Yu., Kretov A.S., Kasymova O.A., et al. The Formation of Risk Groups for Development of Occupational Diseases During the Pre-Employment and Periodic Medical Examinations to Conduct Recreational Activities. Saratov Journal of Medical Scientific Research. 2014;10;4:754–758 (In Russ.).

6. Akleyev A.V., Varfolomeyeva T.A. Status of Hematopoiesis in Residents of the Techa Riverside Villages. Consequences of Radioactive Contamination of the Techa river. Ed. Akleyev A.V. Chelyabinsk Publ., 2016. Р. 166–194 (In Russ.). DOI: 10.7868/S0869803117020060.

7. Sources, Effects and Risks Of Ionizing Radiation. United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2020/2021. Report to the General Assembly, with Scientific Annexes. V.III. Scientific Annex C. New York, United Nations. 2021. 244 р.

8. Akleyev A.A., Vozilova A.V. The Functional State of the Immune System In Irradiated Persons with Increased Levels of Chromosomal Aberrations. Russian Journal of Immunology. 2017;11;3:359–360. (In Russ.).

9. Akleyev A.A., Blinova E.A., Dolgushin II. Immunological Status of Chronically Exposed Persons with Increased Level of TCR Mutations. Radiation and Environmental Biophysics. 2019;58;1:81–88. DOI: 10.1007/s00411-018-0766-1.

10. Kotikova A.I., Blinova E.A., Akleyev A.A. Associaton between Immune System`S Genes Polymorphisms and Immunity Parameters in Persons Exposed to Chronic Radiation Exposure. Health Physics. 2018;115;S1:S47.

11. Krestinina L.Yu., Silkin S.S., Degteva M.O., Akleyev A.V. Risk Analysis of the Mortality from the Diseases of the Circulatory System in the Ural Cohort of Emergency-Irradiated Population for the Years 1950-2015. Radiation Hygiene. 2019;12;1:52–61 (In Russ.). DOI: 10.21514/1998-426X-2019-12-1-52-61.

12. Blinova E.A., Akleyev A.A. Analysis of the Apoptotic Death Indicators of Lymphocytes among the Persons Exposed to Chronic Irradiation. Russian Journal of Immunology. 2017;11;2:107–109. (In Russ.).

13. Kodintseva Е.А., Akleyev А.А., Blinova Е.А., Akleyev A.V. Cytokine Profile in the Subjects after Long-Term in Utero and Postnatal Exposure to Chronic Irradiation. Russian Journal of Immunology. 2021;24;2:275–282 (In Russ.). DOI: 10.46235/1028-7221-1005-CPI.

14. Kodintseva Е.А., Akleyev А.А., Blinova Е.А. The Cytokine Profile of Chronically Irradiated People in Long Terms after the Beginning of Irradiation. Radiacionnaja Biologija. Radiojekologija. 2021;61;5:506–514 (In Russ.). DOI: 10.31857/S0869803121050076.

15. Akleyev А.А., Dolgushin I.I. Immune Status of Persons with CRS at Later Time Points. Radiation and Risk. 2018;27;2:7666–7685 (In Russ.). DOI: 10.21870/0131-3878-2018-27-2-76-85.

16. Marchal J., Pifferi F., Aujard F. Resveratrol in Mammals: Effects on Aging Biomarkers, Age-Related Diseases, and Life Span. Annals of the New York Academy of Sciences. 2013;1290;1:67–73.

17. Guide to Cancer Early Diagnosis. Geneva, World Health Organization, 2018. Licence: CC BY-NC-SA 3.0 IGO. 

18. Khaydukov S.V., Baydun L.V., Zurochka A.V., Totolyan Areg A. The Standardised Technique: «Study Subpopulations of Peripheral Blood Lymphocytes by Using Flow Cytometry». Russian Journal of Immunology. 2014;8;4:974–992 (In Russ.).

19. Khaydukov S.V., Zurochka A.V. Flow Cytometry as a Modern Analytical Tool in Biology and Medicine. Medical Immunology. 2007;9;4-5:373-378 (In Russ.). 

 

 

 PDF (RUS) Full-text article (in Russian)

 

Acknowledgments. The authors would like to thank N. V. Startsev, Head of the Department of the Database “Man”.

Conflict of interest. The authors declare no conflict of interest.

Financing. This study was carried out within the framework of the state assignment of the FMBA of Russia: “The state of human cellular immunity in the period of the development of late effects of chronic radiation exposure”.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.04.2023. Accepted for publication: 27.05.2023.

 

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