JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2023. Vol. 68. № 5
DOI:10.33266/1024-6177-2023-68-5-77-81
D.A. Plaskeeva1, A.I. Konovalov2, Zh.A. Startseva2, S.G. Afanasyev2
Thermoradiochemotherapy in the Combined Treatment of Rectal Cancer
1 Tomsk Regional Oncology Center, Tomsk, Russia
2 Tomsk National Research Medical Center, Tomsk, Russia
Contact person: D.A. Plaskeeva, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Currently, the treatment of rectal cancer requires a multidisciplinary approach. So the combined method of treatment, including chemoradiotherapy and the surgical stage, has proven itself reliably. However, the desired results that significantly increase the rates of relapse-free and metastatic survival have not yet been achieved. The use of radio modifiers makes it possible to enhance radiation exposure without increasing the total focal dose. One of the universal radio modifiers is local hyperthermia.
Purpose: To develop a method of thermoradiochemotherapy in the combined treatment of distal rectal cancer and evaluate its effectiveness.
Material and methods: This work is based on the analysis of the results of treatment of 141 patients with morphologically confirmed locally advanced distal rectal cancer. In accordance with the objectives of the study, all patients were divided into 2 groups. In the combined treatment of 75 patients, the first stage was performed chemoradiotherapy (CLT) in combination with local hyperthermia (LH). Local hyperthermia was not used in the treatment of 66 patients.
Results: Long-term results of complex treatment of patients with an independent course of chemoradiotherapy/thermochemoradiotherapy (dynamic observation group) and after surgical treatment are presented. One – year relapse-free survival in the group with an independent course of TRHT was 96.7 %, in the CLT group – 79.3 % (p=0.024). There was a significant increase in three–year relapse-free survival – 93.3 % versus 76.7 % in the control (p=0.041). Among patients who underwent surgical treatment at the second stage, the study of one-year relapse-free survival did not reveal statistical significance. Three – year relapse-free survival in patients with TRHT compared with the CLT group was 96.2 % versus 86.0 % (p=0.038). The effectiveness of thermoradiochemotherapy in patients of this category was evaluated. The tolerability of treatment in all patients is satisfactory. Among all radiation reactions, the most frequently observed phenomena of radiation epidermitis I–II art. in the projection of irradiation fields (Table 1). Acute radiation reactions were reversible and did not have a negative effect on the subsequent stages of treatment. Treatment for all patients (n=141) was implemented in full.
Keywords: rectal cancer, combined treatment, surgery, local hyperthermia, radiation therapy, chemotherapy
For citation: Plaskeeva DA, Konovalov AI, Startseva ZhA, Afanasyev SG. Thermoradiochemotherapy in the Combined Treatment of Rectal Cancer. Medical Radiology and Radiation Safety. 2023;68(5):77–81. (In Russian). DOI:10.33266/1024-6177-2023-68-5-77-81
References
1. World Health Statistics 2021: Monitoring Health for the SDGs, Sustainable Development Goals. Geneva, World Health Organization, 2021. Licence: CC BY-NC-SA 3.0 IGO, ISBN 978-92-4-002705-3.
2. Kaprin A.D., Starinskiy V.V., Shakhzadova A.O. Malignant Neoplasms in Russia in 2021 (Morbidity and Mortality). Moscow Publ., 2022 (In Russ.).
3. Starodubtseva D.A., Startseva Zh.A., Afanasyev S.G., Dobrodeyev A.Yu. Thermoradiotherapy in Combined Modality Treatment for Rectal Cancer (Literature Review). Sibirskiy Onkologicheskiy Zhurnal = Siberian Journal of Oncology. 2018;17;2:89–94. doi: 10.21294/1814-4861-2018-17-2-89-94 (In Russ.).
4. Barsukov Yu.A., Kuzmichev D.V. Tkachev S.I. Aliyev V.V., et al. Combination Neoadjuvant Thermochemical Therapy in Patients with Rectal Cancer. Oncological Coloproctology. 2014;3:23-28. DOI:10.17650/2220-34782014-0-3-23-28
(In Russ.).
5. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2018;68;6:394-424. doi: 10.3322/caac.21492.
6. Glimelius B. The Swedish Approach. Comprehensive Rectal Cancer Care. Ed. Kwaan M., Zbar A. Springer, Cham, 2019. P. 335-353. doi:10.1007/978-3-319-98902-0_19.
7. Lanning R.M., Goodman K.A. Radiation Therapy: The North American Approach. Comprehensive Rectal Cancer Care. Ed. Kwaan M., Zbar A. Springer, Cham, 2019. P. 365-403. doi: 10.1007/978-3-319-98902-0_21.
8. Dayde D., Tanaka I., Jain R., Tai M.C., Taguchi A. Predictive and Prognostic Molecular Biomarkers for Response to Neoadjuvant Chemoradiation in Rectal Cancer. Int. J. Mol. Sci. 2017;18;3:573. doi: 10.3390/ijms18030573.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Startseva Zh.A.: scientific management of the research, correction of the content of the article, approval of the final version of the article; Afanasyev S.G.: scientific management of the research, correction of the content of the article, approval of the final version of the article; Plaskeeva D.A.: analysis and interpretation of the results of the work, writing the text, collecting clinical material; Konovalov A.I.: development of the concept and design of the study, correction of the content of the article.
Article received: 20.04.2023. Accepted for publication: 27.05.2023.