JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 3
DOI:10.33266/1024-6177-2024-69-3-19-25
T.R. Gaynutdinov1, 2, S.A. Ryzhkin1, 2, 3, 4, 5, K.N. Vagin1, 2, E.Yu. Trizna2,
S.E. Ohrimenko3, 6
Study of Clinical, Hematologic and Immunologic Parameters in Assessing the Anti-Radiation Efficacy of the Therapeutic Agent Based on the Microorganism Fusobacterium Necrophorum
1 Federal Center for Toxicological, Radiation and Biological Safety, Kazan, Russia
2 Kazan Federal University, Kazan, Russia
3 Russian Medical Academy of Continuing Professional Education, Moscow, Russia
4 Kazan State Medical University, Kazan
5 Academy of Sciences of the Republic of Tatarstan, Kazan, Russia
6 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Timur Rafkatovich Gaynutdinov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study clinical, hematologic and immunologic parameters in assessing the anti-radiation efficacy of the therapeutic agent based on the microorganism Fusobacterium necrophorum.
Material and methods: The studies on determination of the anti-radiation efficacy of the strains of microorganisms killed by gamma-irradiation were carried out on sexually mature sexless white mice and white rats with live weight of 18–20 and 180–200 g, respectively, divided into experimental and control groups according to the principle of analogs. Modeling of acute radiation sickness was carried out on a Puma gamma unit with a radioactive source of cesium-137 at a dose of LD100/30. As potential anti-radiation drugs we used inactivated by irradiation on the gamma unit Explorer preparations of microbial origin F. necrophorum strain 8. necrophorum strain 8TS630501 at doses of 15, 20, 25 and 30 kGy. The tested preparations were injected subcutaneously in the volume of 0.2 cm3 to white mice and 2.0 cm3 to white rats 3 days after radiation exposure.
Results: It was experimentally established that complete sterilization of the microbe occurs at doses of 25 and 30 kGy. The culture of
F. necrophorum, irradiated at doses of 25 and 30 kGy and administered to animals 3 days after external radiation exposure, promoted survival, preservation of 60 to 80 % of lethally irradiated white mice and rats. At the same time the recovery of leukocytes and hemoglobin number was slow and continued until the end of the study. In animals treated with the developed therapeutic agents, there was also a decrease in the number of T-cells, but it was less pronounced than in the irradiation control group. The number of B-lymphocytes was affected similarly to T-lymphocytes. The minimum of the number of B-lymphocytes in the experimental groups was noted at 14 days. Studies on the intensity of the process of lipid peroxidation (LPO) in the content of malonic dialdehyde in peripheral blood of gamma-irradiated, treated and intact rats, it was found that in the irradiated control group there is a significant increase in the LPO index in blood in relation to biological control and treatment groups.
Conclusion: It has been established that the highest anti-radiation efficacy is possessed by a therapeutic agent of microbial origin (RNF-30), which was obtained by gamma-irradiation at a dose of 30 kGy of the culture of F. necrophorum.
Keywords: acute radiation disease, Fusobacterium necrophorum, anti-radiation agent, laboratory animals, clinical, hematological and immunological parameters, radiotoxins, survival rate
For citation: Gaynutdinov TR, Ryzhkin SA, Vagin KN, Trizna EYu, Ohrimenko SE. Study of Clinical, Hematologic and Immunologic Parameters in Assessing the Anti-Radiation Efficacy of the Therapeutic Agent Based on the Microorganism Fusobacterium Necrophorum. Medical Radiology and Radiation Safety. 2024;69(3):19–25. (In Russian). DOI:10.33266/1024-6177-2024-69-3-19-25
References
1. Baird E., Reid C., Cancio L.C., Gurney J.M, Burmeister D.M. A Case Study Demonstrating Tolerance of the Gut to Large Volumes of Enteral Fluids in Burn Shock. Int J Burns Trauma. 2021;11(3):202–206. doi: 10.1002/14651858.CD007715.pub2. PMID: 34336386 PMCID: PMC8310868.
2. Cannon G., Kiang J.G. An Overview of the Impact of Radiation on Ecology: Wildlife Population. Int J Radiat Biol. 2020;1–9. Online ahead of print. Doi: 10.1080/09553002.2020.1793021. PMID: 32663058.
3. Burmeister D.M., Johnson T.R., Lai Z., Scroggins S., DeRosa M., Jonas R.B., Zhu C., Scherer E., Stewart R.M., Schwacha M.G., Jenkins D.H., Eastridge B.J., Nicholson S.E. The Gut Microbiome Distinguishes Mortality in Trauma Patients Upon Admission to the Emergency Department. J Trauma Acute Care Surg. 2020;88(5):579–587. Doi:10.1097/TA.0000000000002612 PMID: 32039976 PMCID: PMC7905995
4. Jones C.B., Davis C.M., Sfanos K.S. The Potential Effects of Radiation on the Gut-Brain Axis. Radiat Res. 2020;193(3):209–222. Doi: 10.1667/RR15493.1. PMID: 31898468 Review.
5. Kalkeri R., Walters K., Pol W.V.D., McFarland B.C., Fisher N., Koide F., Morrow C.D., Singh V.K. Changes in the Gut Microbiome Community of Nonhuman Primate Following Radiation Injury. BMC Microbiome. 2021;21(1):93. Doi: 10.1186/s12866-021-02146-w PMID: 33781201.
6. Kiang J.G., Smith J.T., Cannon G., Anderson M.N., Ho C., Zhai M., Cui W., Xiao M. Ghrelin, a Novel Therapy, Corrects Cytokine and NF-kB-AKT-MAPK Network and Mitigates Intestinal Injury Induced by Combined Radiation and Skin-Wound Trauma. Cell Biosci. 2020;10:63. Doi: 10.1186/s13578-020-00425-z PMID: 32426105.
7. Гайнутдинов Т.Р., Вагин К.Н., Рыжкин С.А. Способ лечения радиационно-термических ожогов // Радиация и риск. Бюллетень национального радиационно-эпидемиологического регистра. 2023. Т.32, №1. С 108–117. [Gaynutdinov T.R., Vagin K.N., Ryzhkin S.A. Method of Treatment of Radiation-Thermal Burns. Radiatsiya i Risk = Radiation and risk. Bulletin of the National Radiation-Epidemiological Register. 2023;32(1):108–117 (In Russ.)]. DOI: 10.21870/0131-3878-2023-32-1-108-117
8. DiCarlo A.L., Bandremer A.C., Hollingsworth B. A., Kasim S., Laniyonu A., Todd N.F., Wang S.J., Wertheimer E.R., Rios, C.I. Cutaneous Radiation Injuries: Models, Assessment and Treatments. Radiation research. 2020;194(3):315–344. Doi: 10.1667/RADE-20-00120.1.
9. Körmöndi S., Terhes G., Pál Z., Varga E., Harmati M., Buzás K., Urbán E. Human Pasteurellosis Health Risk for Elderly Persons Living with Companion Animals. Emerging infectious diseases. 2019;25(2):229–235. Doi: 10.3201/eid2502.180641.
10. Peng Z., Wang X., Zhou R., Chen H., Wilson B.A., Wu B. Pasteurella Multocida: Genotypes and Genomics. Microbiology and Molecular Biology Reviews: MMBR. 2019;83(4):e00014-19. Doi: 10.1128/MMBR.00014-19
11. Kannangara D.W., Pandya D., Patel P. Pasteurella multocida Infections with Unusual Modes of Transmission from Animals to Humans: a Study of 79 Cases with 34 Nonbite Transmissions. Vector Borne Zoonotic Dis. 2020;Sep;20(9):637–651. Doi: 10.1089/vbz.2019.2558. Epub 2020 May 18. PMID: 32423307.
12. Shome R., Deka R.P., Sahay S., Grace D., Lindahl J.F. Seroprevalence of Hemorrhagic Septicemia in Dairy Cows IN Assam, India. Infection Ecology and Epidemiology. 2019;9(1):1604064. Doi: 10.1080/20008686.2019.1604064.
13. Davis C.M., Allen A.R., Bowles D.E. Consequences of Space Radiation on the Brain and Cardiovascular System. J Environ Sci Health C Toxicol Carcinog. 2021;39(2):180–218. Doi: 10.1080/26896583.2021.1891825 PMID: 33902387
14. Gorbunov N.V., Kiang J.G. Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury. Radiat Res. 2021;196(1):1–16. Doi: 10.1667/RADE-20-00147.1. PMID: 33979447.
15. Wang Z., Wang Q., Wang X., Zhu L., Chen J., Zhang B., Chen Y., Yuan, Z. Gut Microbial Dysbiosis is Associated with Development and Progression of Radiation Enteritis during Pelvic Radiotherapy. Journal of Cellular and Molecular Medicine. 2019;23(5):3747–3756. Doi: 10.1111/jcmm.14289
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out at the expense of the funds of the subsidy allocated by the Federal State Budgetary Institution “FCTRB-VNIVI” for the performance of research work, state registration No. 01200202604.
Contribution. T.R. Gaynutdinov – a literary review on the topic of the article was conducted, the experimental part of the work was performed, the received material was processed, the text was edited, the manuscript was prepared. S.A. Ryzhkin – scientific guidance. K.N. Vagin – advisory assistance was provided on the implementation of research. E.Y. Trizna –the experimental part of the work was performed. S.E. Okhrimenko – advisory assistance was provided in the implementation of the experimental part of the work..
Article received: 20.01.2024. Accepted for publication: 27.02.2024.