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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-42-52
V.V. Vostrotin
Using the Bayesian Approach for the Case of Acute Inhalation of Pu-239 Industrial Compounds
Southern Urals Biophysics Institute, Ozyorsk, Russia
Contact person: V.V. Vostrotin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Introduction: The Bayesian approach has found wide application for the tasks of estimating doses of internal exposure under various intake scenarios. The South Ural Institute of Biophysics has accumulated considerable experience in using the Bayesian approach to estimate the expected effective doses of internal exposure for current individual dosimetry control when radionuclides intake into body by various ways. Attributing the type of compounds Moderate or Slow according to the NRB-99/2009 classification for acute inhalation of industrial Pu-239 compounds bias dose estimates to the lungs, which leads to the need to develop a new methodology.
Purpose: The development of a calculation methodology using the Bayesian approach for the case of acute inhalation of industrial Pu-239 compounds into the human body and its testing in artificial cases.
Material and methods: A technique is presented for interpreting a series of measurement results of Pu-239 activity in daily urine and/or daily feces to assess the distribution of intake, two key parameters of the biokinetic model of ICRP Publication 66 (the proportion of rapid absorption fr and the rate of slow absorption into the blood ss), as well as annual weighted equivalent doses to the lungs. The technique allows using a prior information about the estimated parameters and correctly processing measurement results below the detection limit.
Results: A jDose program has been created that implements the technique in ~ 20 minutes on a modern office computer. The program was tested on artificial cases with 10 measurements of Pu-239 activity in daily urine and 10 in daily feces during the first 10 days after acute inhalation intake at AMAD = 1 µm. Testing showed reproducibility of the set «true» parameter values in the range (average ± 2 standard deviations) with an increase in the proportion of unreliable measurement results. The increase in the proportion of unreliable measurement results had the greatest impact on the estimation of the coefficient of variation of the slow absorption rate parameter into the blood ss.
Keywords: plutonium, inhalation intake, internal exposure, Bayesian approach
For citation: Vostrotin VV. Using the Bayesian Approach for the Case of Acute Inhalation of Pu-239 Industrial Compounds. Medical Radiology and Radiation Safety. 2024;69(5):42–52. (In Russian). DOI:10.33266/1024-6177-2024-69-5-42-52
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declares that there are no conflicts of interest.
Financing. The work was carried out within the framework of the research project « Improvement of control methods and study of the peculiarities of the formation of internal radiation doses for the personnel of Mayak PA and the population of adjacent territories», cipher «Control-22», funded by the FMBA of Russia.
Contribution. Conceptual development, creation of R scripts, mathematical calculations and their quality control were carried out by one author.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.