JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2024. Vol. 69. № 5
DOI:10.33266/1024-6177-2024-69-5-87-94
S.Yu. Chekin, S.V. Karpenko, M.A. Maksioutov, P.V. Kascheeva,
A.M. Korelo, N.V. Shchukina, E.V. Kochergina, O.E. Lashkova, N.S. Zelenskaya
Assessment of Radiation Risks of Mortality from Circulatory System Diseases in the Cohort of Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant, Considering the Influence of Other Diseases Identified During the Observation Period
A.F. Tsyb Medical Radiological Research Center, Obninsk, Russia
Contact person: S.Yu. Chekin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To assess the radiation risk of mortality from circulatory system diseases (CSD) in the cohort of liquidators of the consequences of the Chernobyl accident, considering the impact of other diseases detected in them during the observation period.
Material and methods: Radiation risks of mortality from CSD were studied in the cohort of liquidators of the consequences of the Chernobyl accident observed in the National Radiation and Epidemiological Register (NRER) system from 1986 to 2022. The studied deaths are included in the codes I00–I99 of the International Statistical Classification of Diseases of the 10th Revision (ICD-10). Among the 89,594 members of the studied cohort, 16,780 deaths from CSD were identified. Mean age at the beginning of exposure was 34 years, the average absorbed dose of external gamma exposure of the whole body was 0.133 Gy, the maximum dose was 1.5 Gy, the average duration of exposure was 2.6 months. To analyze the dependence of the radiation risk of mortality from CSD on the presence of other diseases in them, regression models of excess relative risk (ERR) and nonparametric relative risk (RR) estimates in dose groups were used.
Results: The average estimate of the excess relative risk ratio ERR/Gy=0.53 for the entire cohort, which is quantitatively comparable to the previously obtained estimate of ERR/Gy=0.74 for mortality from solid malignancies in the same cohort. The assessment of the radiation risk of mortality from CSD in the cohort of liquidators of the consequences of the Chernobyl accident depends on the presence of diseases from other categories identified in them during the observation period. Diseases of respiratory (J00-J99) and digestive organs (K00–K93) are radiation-competing risk factors for death from CSD. The risk group for radiation-related mortality from CSD with an estimate of ERR/Gy=1.22 consists of relatively healthy liquidators without respiratory and digestive diseases. Nonparametric estimates of relative radiation risk (RR) confirm the correctness of the linear non-threshold model of radiation risk of mortality of liquidators from CSD, regardless of the degree of multimorbidity of their health status.
Conclusions: The practical dose thresholds for mortality of liquidators from CSD depend on their health status and are in the range of 0.01–0.21 Gy, which is significantly less than the currently accepted ICRP level of 0.5 Gy. The determination of such thresholds does not mean that there is no effect of radiation at doses below the threshold doses. Further accumulation of radiation and epidemiological data in the NRER system will allow for the analysis of radiation risks considering multimorbidity, more detailed by diagnosis.
Keywords: radiation risk, liquidators, National Radiation and Epidemiological Register, diseases of the circulatory system, relative risk, linear non-threshold model, multiplicative model, excess relative risk
For citation: Chekin SYu, Karpenko SV, Maksioutov MA, Kascheeva PV, Korelo AM, Shchukina NV, Kochergina EV, Lashkova OE,
Zelenskaya NS. Assessment of Radiation Risks of Mortality from Circulatory System Diseases in the Cohort of Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant, Considering the Influence of Other Diseases Identified During the Observation Period. Medical Radiology and Radiation Safety. 2024;69(5):87–94. (In Russian). DOI:10.33266/1024-6177-2024-69-5-87-94
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2024. Accepted for publication: 25.06.2024.